Insulin Action and Its Disturbances in Disease - part 9 docx
Insulin Action and Its Disturbances in Disease - part 9 docx
... PKC and IKK-
β-mediated serine phosphorylation of IRS-1, inhibiting insulin- induced tyrosine
phosphorylation of IRS-1 and IRS-1-associated PI3-kinase activity, ultimately
leading to a fall in insulin- stimulated ... and Lorenzo, M. ( 199 8) Tumor
necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and
inhibits insulin- induced adipogenesis...
Insulin Action and Its Disturbances in Disease - part 9 pot
... within myocytes. This accumulation triggers PKC and IKK-
β-mediated serine phosphorylation of IRS-1, inhibiting insulin- induced tyrosine
phosphorylation of IRS-1 and IRS-1-associated PI3-kinase ... D-chiro-inositol-containing phosphoglycans that mediate
insulin action, the administration of this substance could improve insulin
sensitivity. According to this hypothesis D-chiro-inosi...
Insulin Action and Its Disturbances in Disease - part 1 ppsx
... Data
Insulin resistance : insulin action and its disturbances in disease / editors, Sudhesh
Kumar, Stephen O’Rahilly.
p. cm.
Includes bibliographical references and index.
ISBN 0-4 7 0-8 500 8-6
1. Insulin ... perhaps, in view of the data obtained from over-expression
studies, knockout of APS in mice results in a phenotype of increased insulin
sensitivity a...
Insulin Action and Its Disturbances in Disease - part 3 pptx
... (eIF-4E), eIF-4G and phospho-
rylated heat–acid-stable protein (PHAS-1) are in uenced by insulin. PHAS-1
binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of
PHAS-1 and ... T., and Rennie, M. J. ( 199 0)
Inability to stimulate skeletal muscle or whole body protein synthesis in type I (insulin-
dependent) diabetes patients by insulin- plus-glucose during a...
Insulin Action and Its Disturbances in Disease - part 4 pdf
... the renin–angiotensin system (RAS), plasminogen activator
inhibitor-1 (PAI-1) and more recently omentin and visfatin.
79
TheroleofTNF-α,
leptin, Il-6, resistin and adiponectin in linking obesity ... peripheral insulin levels for insulin- induced suppression of glucose pro-
duction in depancreatized dogs. J Clin Invest 90 , 17 69 1777.
85. Cherrington, A. D., Edgerton, D. and...
Insulin Action and Its Disturbances in Disease - part 5 pptx
... resistin levels in obesity.
2 09
The resistin mRNA encodes
a 114-amino-acid polypeptide containing a 20-amino-acid signal sequence. The
secreted protein, resistin, is a 94 -amino-acid disulfide-linked ... depend in part on activation of phosphatidyl inositol-3-kinase down-
stream from IRS1 and 2. However, a second pathway, involving interaction of
the tyrosine kinase cCbl with the i...
Insulin Action and Its Disturbances in Disease - part 6 pps
... insulin action via increased insulin receptor expression and increased
activation of insulin receptor kinase.
91
11.4 Summary
Whole body insulin sensitivity is the product of a complex interaction ... years
BMI:
Ethnicity: Chinese
(Guangdong Province)
MOSPA
questionnaire
Fasting serum insulin
(Fasting insulin
resistance index: ‘a
multiplication
value of fasting
insulin an...
Insulin Action and Its Disturbances in Disease - part 8 pdf
... appearances
0
50
100
150
200
250
300
350
400
198 8 199 0 199 2 199 4 199 6 199 8 2000 2002
Metabolic syndrome
Syndrome X
Insulin resistance syndrome
Figure 14.1 Interest in the insulin resistance syndrome in the scientific community, ... also
been proposed to link obesity with insulin resistance, with serine phospho-
rylation of the insulin receptor substrate-1 being a prominent m...
Insulin Action and Its Disturbances in Disease - part 10 ppt
... Relationship to insulin resistance. J Clin
Invest 97 , 1111–1116.
1 59. Hotamisligil, G. S. et al. ( 199 6) IRS-1-mediated inhibition of insulin receptor tyro-
sine kinase activity in TNF- - and obesity-induced ... negative role in insulin signalling and its inhibition
improves insulin sensitivity.
SHIP2 is another negative regulator of insulin signalling. Overexpressi...
Insulin Action and Its Disturbances in Disease - part 2 pptx
... E. ( 199 8) The interaction of Janus
kinases JAK-1 and JAK-2 with the insulin receptor and insulin- like growth factor-1
receptor. Endocrinology 1 39, 884– 893 .
358. Sawka-Verhelle, D., Tartare-Deckert, ... hypertriglyceridaemia and insufficient insulin action
such as in insulin resistance.
The strongest evidence for a link between insulin action and gene transcrip-
tio...
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