Insulin Action and Its Disturbances in Disease - part 9 docx
Insulin Action and Its Disturbances in Disease - part 9 docx
... PKC and IKK- β-mediated serine phosphorylation of IRS-1, inhibiting insulin- induced tyrosine phosphorylation of IRS-1 and IRS-1-associated PI3-kinase activity, ultimately leading to a fall in insulin- stimulated ... and Lorenzo, M. ( 199 8) Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin- induced adipogenesis...
Ngày tải lên: 09/08/2014, 15:20
Insulin Action and Its Disturbances in Disease - part 9 pot
... within myocytes. This accumulation triggers PKC and IKK- β-mediated serine phosphorylation of IRS-1, inhibiting insulin- induced tyrosine phosphorylation of IRS-1 and IRS-1-associated PI3-kinase ... D-chiro-inositol-containing phosphoglycans that mediate insulin action, the administration of this substance could improve insulin sensitivity. According to this hypothesis D-chiro-inosi...
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Insulin Action and Its Disturbances in Disease - part 1 ppsx
... Data Insulin resistance : insulin action and its disturbances in disease / editors, Sudhesh Kumar, Stephen O’Rahilly. p. cm. Includes bibliographical references and index. ISBN 0-4 7 0-8 500 8-6 1. Insulin ... perhaps, in view of the data obtained from over-expression studies, knockout of APS in mice results in a phenotype of increased insulin sensitivity a...
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Insulin Action and Its Disturbances in Disease - part 3 pptx
... (eIF-4E), eIF-4G and phospho- rylated heat–acid-stable protein (PHAS-1) are in uenced by insulin. PHAS-1 binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of PHAS-1 and ... T., and Rennie, M. J. ( 199 0) Inability to stimulate skeletal muscle or whole body protein synthesis in type I (insulin- dependent) diabetes patients by insulin- plus-glucose during a...
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Insulin Action and Its Disturbances in Disease - part 4 pdf
... the renin–angiotensin system (RAS), plasminogen activator inhibitor-1 (PAI-1) and more recently omentin and visfatin. 79 TheroleofTNF-α, leptin, Il-6, resistin and adiponectin in linking obesity ... peripheral insulin levels for insulin- induced suppression of glucose pro- duction in depancreatized dogs. J Clin Invest 90 , 17 69 1777. 85. Cherrington, A. D., Edgerton, D. and...
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Insulin Action and Its Disturbances in Disease - part 5 pptx
... resistin levels in obesity. 2 09 The resistin mRNA encodes a 114-amino-acid polypeptide containing a 20-amino-acid signal sequence. The secreted protein, resistin, is a 94 -amino-acid disulfide-linked ... depend in part on activation of phosphatidyl inositol-3-kinase down- stream from IRS1 and 2. However, a second pathway, involving interaction of the tyrosine kinase cCbl with the i...
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Insulin Action and Its Disturbances in Disease - part 6 pps
... insulin action via increased insulin receptor expression and increased activation of insulin receptor kinase. 91 11.4 Summary Whole body insulin sensitivity is the product of a complex interaction ... years BMI: Ethnicity: Chinese (Guangdong Province) MOSPA questionnaire Fasting serum insulin (Fasting insulin resistance index: ‘a multiplication value of fasting insulin an...
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Insulin Action and Its Disturbances in Disease - part 8 pdf
... appearances 0 50 100 150 200 250 300 350 400 198 8 199 0 199 2 199 4 199 6 199 8 2000 2002 Metabolic syndrome Syndrome X Insulin resistance syndrome Figure 14.1 Interest in the insulin resistance syndrome in the scientific community, ... also been proposed to link obesity with insulin resistance, with serine phospho- rylation of the insulin receptor substrate-1 being a prominent m...
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Insulin Action and Its Disturbances in Disease - part 10 ppt
... Relationship to insulin resistance. J Clin Invest 97 , 1111–1116. 1 59. Hotamisligil, G. S. et al. ( 199 6) IRS-1-mediated inhibition of insulin receptor tyro- sine kinase activity in TNF- - and obesity-induced ... negative role in insulin signalling and its inhibition improves insulin sensitivity. SHIP2 is another negative regulator of insulin signalling. Overexpressi...
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Insulin Action and Its Disturbances in Disease - part 2 pptx
... E. ( 199 8) The interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and insulin- like growth factor-1 receptor. Endocrinology 1 39, 884– 893 . 358. Sawka-Verhelle, D., Tartare-Deckert, ... hypertriglyceridaemia and insufficient insulin action such as in insulin resistance. The strongest evidence for a link between insulin action and gene transcrip- tio...
Ngày tải lên: 09/08/2014, 15:20