Insulin Action and Its Disturbances in Disease - part 7 pptx
Insulin Action and Its Disturbances in Disease - part 7 pptx
... fasting and
post-challenge
insulin
Intervention group
had significantly
lower fasting
insulin at baseline
compared with
controls
(p = 0.0001).
No difference in
delta fasting
insulin during
follow-up
188 ... with
annual check-ups
OGTT – fasting and
post-challenge
insulin
Reduction in 0,
40 min increment,
and 2 h insulin
during
intervention
(p<0.0001) in
intervention
gro...
Insulin Action and Its Disturbances in Disease - part 3 pptx
... (eIF-4E), eIF-4G and phospho-
rylated heat–acid-stable protein (PHAS-1) are in uenced by insulin. PHAS-1
binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of
PHAS-1 and ... Taha, C., Grinstein, S. and Klip, A. (1996) Insulin activates a p2 1-
activated kinase in muscle cells via phosphatidylinositol 3-kinase. JBiolChem 271 ,
19 664–19 6 67.
37. Pin,...
Insulin Action and Its Disturbances in Disease - part 5 pptx
... adipocyte-
derived signalling molecule that reduces insulin- stimulated glucose uptake
75
and
is found in high concentrations in obese and insulin- resistant individuals.
76 , 77
TNFα expression is inhibited ... resistin levels in obesity.
209
The resistin mRNA encodes
a 114-amino-acid polypeptide containing a 20-amino-acid signal sequence. The
secreted protein, resistin, is a...
Insulin Action and Its Disturbances in Disease - part 2 pptx
... and
SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS-1 and IRS-2.
JBiolChem 277 , 42 394–42 398.
178 . White, M. F. (19 97) The insulin signalling system and the IRS proteins. ... hypertriglyceridaemia and insufficient insulin action
such as in insulin resistance.
The strongest evidence for a link between insulin action and gene transcrip-
tion...
Insulin Action and Its Disturbances in Disease - part 1 ppsx
... action of insulin 471
15 .7 What causes abnormal insulin signalling in metabolic and vascular tissues? 474
15.8 Summary and conclusions (Figure 15.8) 477
References 478
16 Insulin Resistance and ... resistance : insulin action and its disturbances in disease / editors, Sudhesh
Kumar, Stephen O’Rahilly.
p. cm.
Includes bibliographical references and index....
Insulin Action and Its Disturbances in Disease - part 4 pdf
... the renin–angiotensin system (RAS), plasminogen activator
inhibitor-1 (PAI-1) and more recently omentin and visfatin.
79
TheroleofTNF-α,
leptin, Il-6, resistin and adiponectin in linking obesity ... fibrinolysis. This
may be a consequence of compensatory hyperinsulinaemia, as in vitro studies
have demonstrated that insulin and its precursor, proinsulin, increase PAI-1 gene
ex...
Insulin Action and Its Disturbances in Disease - part 6 pps
... insulin action via increased insulin receptor expression and increased
activation of insulin receptor kinase.
91
11.4 Summary
Whole body insulin sensitivity is the product of a complex interaction ... glucose and insulin responses. This apparent effect on insulin sensitiv-
ity may depend on the underlying individual level of insulin resistance. In a
small study of seven...
Insulin Action and Its Disturbances in Disease - part 8 pdf
... identified a
cluster of insulin- resistance-related alterations with 75 per cent accuracy, indi-
cating that circulating PC-1 is related to insulin sensitivity.
176 , 177
In addition,
women with ... population-specific environmental factors.
PC-1
Plasma cell membrane glycoprotein-1 (PC-1) inhibits insulin receptor (IR) tyro-
sine kinase activity and subsequent cellular signalling, po...
Insulin Action and Its Disturbances in Disease - part 9 pot
... within myocytes. This accumulation triggers PKC and IKK-
β-mediated serine phosphorylation of IRS-1, inhibiting insulin- induced tyrosine
phosphorylation of IRS-1 and IRS-1-associated PI3-kinase ... D-chiro-inositol-containing phosphoglycans that mediate
insulin action, the administration of this substance could improve insulin
sensitivity. According to this hypothesis D-chiro-inosi...
Insulin Action and Its Disturbances in Disease - part 10 ppt
... Ser3 07 in insulin receptor substrate-1 blocks
interactions with the insulin receptor and inhibits insulin action. JBiolChem 277 ,
1531–15 37.
154. Jiang, G., Dallas-Yang, Q., Liu, F., Moller, D. E. and ... Relationship to insulin resistance. J Clin
Invest 97, 1111–1116.
159. Hotamisligil, G. S. et al. (1996) IRS-1-mediated inhibition of insulin receptor tyro-
sine kinase a...
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