Insulin Action and Its Disturbances in Disease - part 4 ppsx
Insulin Action and Its Disturbances in Disease - part 4 ppsx
... by epinephrine in man. J Clin Invest 46 , 86– 94. 172 INSULIN RESISTANCE IN GLUCOSE DISPOSAL AND PRODUCTION IN MAN translocation. Although hepatic insulin resistance may play only a minor role in the ... frequency. 45 ICV injection of insulin reduces food intake and body weight in baboons and rodents 171, 172 and administration of anti -insulin antibodies into the...
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Insulin Action and Its Disturbances in Disease - part 1 ppsx
... resistance : insulin action and its disturbances in disease / editors, Sudhesh Kumar, Stephen O’Rahilly. p. cm. Includes bibliographical references and index. ISBN 0 -4 7 0-8 500 8-6 1. Insulin resistance. ... the Grb 14 gene in mice improves glucose tolerance and enhances insulin signalling in liver and muscle but not fat, confirming Grb 14 as a tissue-spec...
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Insulin Action and Its Disturbances in Disease - part 4 pdf
... (TNF-α), interleukin-6 (IL- 6), leptin, resistin, the renin–angiotensin system (RAS), plasminogen activator inhibitor-1 (PAI-1) and more recently omentin and visfatin. 79 TheroleofTNF-α, leptin, ... acids and inhibits pancreatic insulin secretion. 10 11β-HSD AND OBESITY 219 11β-HSD2, a 40 5-amino-acid protein, is encoded for on chromosome 16, and is localized to tissue expressing...
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Insulin Action and Its Disturbances in Disease - part 3 ppsx
... (PHAS-1) are in uenced by insulin. PHAS-1 binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of PHAS-1 and favours dissociation of eIF-4E and PHAS-1. 14 This allows for binding ... the amount of circulating insulin; the biological effect or action of insulin (i.e. insulin sensitivity, S i ); and the impact of glucose itself on its own disposal, inde...
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Insulin Action and Its Disturbances in Disease - part 3 pptx
... (PHAS-1) are in uenced by insulin. PHAS-1 binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of PHAS-1 and favours dissociation of eIF-4E and PHAS-1. 14 This allows for binding ... body protein synthesis in type I (insulin- dependent) diabetes patients by insulin- plus-glucose during amino acid infusion: studies of incorporation and turnover of tracer L-...
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Insulin Action and Its Disturbances in Disease - part 5 pptx
... resistin levels in obesity. 209 The resistin mRNA encodes a 1 1 4- amino-acid polypeptide containing a 20-amino-acid signal sequence. The secreted protein, resistin, is a 9 4- amino-acid disulfide-linked ... resistin expression in vivo in several different models of obesity and insulin resistance. 84 A further possible link between PPARγ action in adipose tissue and insulin...
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Insulin Action and Its Disturbances in Disease - part 6 pps
... insulin action via increased insulin receptor expression and increased activation of insulin receptor kinase. 91 11 .4 Summary Whole body insulin sensitivity is the product of a complex interaction ... glucose and insulin responses. This apparent effect on insulin sensitiv- ity may depend on the underlying individual level of insulin resistance. In a small study of seve...
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Insulin Action and Its Disturbances in Disease - part 8 pdf
... D., Kral, J. G. and Lebovitz, H. E. (1995) Does intra-abdominal adipose tissue in black men determine whether NIDDM is insulin- resistant or insulin- sensitive? Diabetes 44 , 141 – 146 . 16. Albu, J. ... also been proposed to link obesity with insulin resistance, with serine phospho- rylation of the insulin receptor substrate-1 being a prominent mechanism for TNF-α-induced insuli...
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Insulin Action and Its Disturbances in Disease - part 9 pot
... within myocytes. This accumulation triggers PKC and IKK- β-mediated serine phosphorylation of IRS-1, inhibiting insulin- induced tyrosine phosphorylation of IRS-1 and IRS-1-associated PI3-kinase ... abnormality in insulin receptor phos- phorylation in cells from women with PCOS. Increased insulin- dependent serine phosphorylation of the insulin receptor β-subunit in skin fibrob...
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Insulin Action and Its Disturbances in Disease - part 10 ppt
... Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. JBiolChem277, 1531–1537. 1 54. Jiang, G., Dallas-Yang, Q., Liu, F., Moller, D. E. and ... Relationship to insulin resistance. J Clin Invest 97, 1111–1116. 159. Hotamisligil, G. S. et al. (1996) IRS-1-mediated inhibition of insulin receptor tyro- sine kinase activi...
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