Insulin Action and Its Disturbances in Disease - part 10 ppt
Insulin Action and Its Disturbances in Disease - part 10 ppt
... Relationship to insulin resistance. J Clin
Invest 97, 1111–1116.
159. Hotamisligil, G. S. et al. (1996) IRS-1-mediated inhibition of insulin receptor tyro-
sine kinase activity in TNF- - and obesity-induced ... negative role in insulin signalling and its inhibition
improves insulin sensitivity.
SHIP2 is another negative regulator of insulin signalling. Overexpression of...
Insulin Action and Its Disturbances in Disease - part 3 pptx
... (eIF-4E), eIF-4G and phospho-
rylated heat–acid-stable protein (PHAS-1) are in uenced by insulin. PHAS-1
binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of
PHAS-1 and ... T., and Rennie, M. J. (1990)
Inability to stimulate skeletal muscle or whole body protein synthesis in type I (insulin-
dependent) diabetes patients by insulin- plus-glucose during ami...
Insulin Action and Its Disturbances in Disease - part 5 pptx
... resistin levels in obesity.
209
The resistin mRNA encodes
a 114-amino-acid polypeptide containing a 20-amino-acid signal sequence. The
secreted protein, resistin, is a 94-amino-acid disulfide-linked ... depend in part on activation of phosphatidyl inositol-3-kinase down-
stream from IRS1 and 2. However, a second pathway, involving interaction of
the tyrosine kinase cCbl with the insul...
Insulin Action and Its Disturbances in Disease - part 2 pptx
... hypertriglyceridaemia and insufficient insulin action
such as in insulin resistance.
The strongest evidence for a link between insulin action and gene transcrip-
tion regulating lipid metabolism comes from the investigation ... (APS) and SH2-B enhance insulin- receptor
autophosphorylation, extracellular-signal-regulated kinase and phosphoinositide 3-
kinase-dependent si...
Insulin Action and Its Disturbances in Disease - part 7 pptx
... fasting and
post-challenge
insulin
Intervention group
had significantly
lower fasting
insulin at baseline
compared with
controls
(p = 0.0001).
No difference in
delta fasting
insulin during
follow-up
188 ... and
post-challenge
insulin
Reduction in 0,
40 min increment,
and 2 h insulin
during
intervention
(p<0.0001) in
intervention
groups, but not in
control groups.
Red...
Insulin Action and Its Disturbances in Disease - part 1 ppsx
... resistance : insulin action and its disturbances in disease / editors, Sudhesh
Kumar, Stephen O’Rahilly.
p. cm.
Includes bibliographical references and index.
ISBN 0-4 7 0-8 500 8-6
1. Insulin resistance. ... K. Clarke and Vidya Mohamed-Ali
10. 1 Obesity and insulin resistance 270
10. 2 Adipokines implicated in insulin resistance 272
10. 3 Conclusions 280...
Insulin Action and Its Disturbances in Disease - part 4 pdf
... (TNF-α), interleukin-6 (IL-
6), leptin, resistin, the renin–angiotensin system (RAS), plasminogen activator
inhibitor-1 (PAI-1) and more recently omentin and visfatin.
79
TheroleofTNF-α,
leptin, ... acids and inhibits pancreatic
insulin secretion.
10
11β-HSD AND OBESITY 219
11β-HSD2, a 405-amino-acid protein, is encoded for on chromosome 16, and
is localized to tissue expressing...
Insulin Action and Its Disturbances in Disease - part 6 pps
... insulin action via increased insulin receptor expression and increased
activation of insulin receptor kinase.
91
11.4 Summary
Whole body insulin sensitivity is the product of a complex interaction ... years
BMI:
Ethnicity: Chinese
(Guangdong Province)
MOSPA
questionnaire
Fasting serum insulin
(Fasting insulin
resistance index: ‘a
multiplication
value of fasting
insulin and...
Insulin Action and Its Disturbances in Disease - part 8 pdf
... also
been proposed to link obesity with insulin resistance, with serine phospho-
rylation of the insulin receptor substrate-1 being a prominent mechanism for
TNF-α-induced insulin resistance.
228
Physiologically, ... population-specific environmental factors.
PC-1
Plasma cell membrane glycoprotein-1 (PC-1) inhibits insulin receptor (IR) tyro-
sine kinase activity and subsequent cellu...
Insulin Action and Its Disturbances in Disease - part 9 pot
... within myocytes. This accumulation triggers PKC and IKK-
β-mediated serine phosphorylation of IRS-1, inhibiting insulin- induced tyrosine
phosphorylation of IRS-1 and IRS-1-associated PI3-kinase ... D-chiro-inositol-containing phosphoglycans that mediate
insulin action, the administration of this substance could improve insulin
sensitivity. According to this hypothesis D-chiro-inosi...
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