Insulin Action and Its Disturbances in Disease - part 10 ppt
Insulin Action and Its Disturbances in Disease - part 10 ppt
... Relationship to insulin resistance. J Clin Invest 97, 1111–1116. 159. Hotamisligil, G. S. et al. (1996) IRS-1-mediated inhibition of insulin receptor tyro- sine kinase activity in TNF- - and obesity-induced ... negative role in insulin signalling and its inhibition improves insulin sensitivity. SHIP2 is another negative regulator of insulin signalling. Overexpression of...
Ngày tải lên: 09/08/2014, 15:20
Insulin Action and Its Disturbances in Disease - part 3 pptx
... (eIF-4E), eIF-4G and phospho- rylated heat–acid-stable protein (PHAS-1) are in uenced by insulin. PHAS-1 binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of PHAS-1 and ... T., and Rennie, M. J. (1990) Inability to stimulate skeletal muscle or whole body protein synthesis in type I (insulin- dependent) diabetes patients by insulin- plus-glucose during ami...
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Insulin Action and Its Disturbances in Disease - part 5 pptx
... resistin levels in obesity. 209 The resistin mRNA encodes a 114-amino-acid polypeptide containing a 20-amino-acid signal sequence. The secreted protein, resistin, is a 94-amino-acid disulfide-linked ... depend in part on activation of phosphatidyl inositol-3-kinase down- stream from IRS1 and 2. However, a second pathway, involving interaction of the tyrosine kinase cCbl with the insul...
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Insulin Action and Its Disturbances in Disease - part 2 pptx
... hypertriglyceridaemia and insufficient insulin action such as in insulin resistance. The strongest evidence for a link between insulin action and gene transcrip- tion regulating lipid metabolism comes from the investigation ... (APS) and SH2-B enhance insulin- receptor autophosphorylation, extracellular-signal-regulated kinase and phosphoinositide 3- kinase-dependent si...
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Insulin Action and Its Disturbances in Disease - part 7 pptx
... fasting and post-challenge insulin Intervention group had significantly lower fasting insulin at baseline compared with controls (p = 0.0001). No difference in delta fasting insulin during follow-up 188 ... and post-challenge insulin Reduction in 0, 40 min increment, and 2 h insulin during intervention (p<0.0001) in intervention groups, but not in control groups. Red...
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Insulin Action and Its Disturbances in Disease - part 1 ppsx
... resistance : insulin action and its disturbances in disease / editors, Sudhesh Kumar, Stephen O’Rahilly. p. cm. Includes bibliographical references and index. ISBN 0-4 7 0-8 500 8-6 1. Insulin resistance. ... K. Clarke and Vidya Mohamed-Ali 10. 1 Obesity and insulin resistance 270 10. 2 Adipokines implicated in insulin resistance 272 10. 3 Conclusions 280...
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Insulin Action and Its Disturbances in Disease - part 4 pdf
... (TNF-α), interleukin-6 (IL- 6), leptin, resistin, the renin–angiotensin system (RAS), plasminogen activator inhibitor-1 (PAI-1) and more recently omentin and visfatin. 79 TheroleofTNF-α, leptin, ... acids and inhibits pancreatic insulin secretion. 10 11β-HSD AND OBESITY 219 11β-HSD2, a 405-amino-acid protein, is encoded for on chromosome 16, and is localized to tissue expressing...
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Insulin Action and Its Disturbances in Disease - part 6 pps
... insulin action via increased insulin receptor expression and increased activation of insulin receptor kinase. 91 11.4 Summary Whole body insulin sensitivity is the product of a complex interaction ... years BMI: Ethnicity: Chinese (Guangdong Province) MOSPA questionnaire Fasting serum insulin (Fasting insulin resistance index: ‘a multiplication value of fasting insulin and...
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Insulin Action and Its Disturbances in Disease - part 8 pdf
... also been proposed to link obesity with insulin resistance, with serine phospho- rylation of the insulin receptor substrate-1 being a prominent mechanism for TNF-α-induced insulin resistance. 228 Physiologically, ... population-specific environmental factors. PC-1 Plasma cell membrane glycoprotein-1 (PC-1) inhibits insulin receptor (IR) tyro- sine kinase activity and subsequent cellu...
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Insulin Action and Its Disturbances in Disease - part 9 pot
... within myocytes. This accumulation triggers PKC and IKK- β-mediated serine phosphorylation of IRS-1, inhibiting insulin- induced tyrosine phosphorylation of IRS-1 and IRS-1-associated PI3-kinase ... D-chiro-inositol-containing phosphoglycans that mediate insulin action, the administration of this substance could improve insulin sensitivity. According to this hypothesis D-chiro-inosi...
Ngày tải lên: 09/08/2014, 15:20