Insulin Action and Its Disturbances in Disease - part 6 pps
Insulin Action and Its Disturbances in Disease - part 6 pps
... insulin action via increased insulin receptor expression and increased activation of insulin receptor kinase. 91 11.4 Summary Whole body insulin sensitivity is the product of a complex interaction ... years BMI: Ethnicity: Chinese (Guangdong Province) MOSPA questionnaire Fasting serum insulin (Fasting insulin resistance index: ‘a multiplication value of fasting insulin and...
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Insulin Action and Its Disturbances in Disease - part 1 ppsx
... resistance : insulin action and its disturbances in disease / editors, Sudhesh Kumar, Stephen O’Rahilly. p. cm. Includes bibliographical references and index. ISBN 0-4 7 0-8 500 8 -6 1. Insulin resistance. ... 467 Stephen J. Cleland and John M. C. Connell 15.1 Introduction 467 15.2 Hyperinsulinaemia, insulin resistance and hypertension 467 15.3 Possible mechan...
Ngày tải lên: 09/08/2014, 15:20
Insulin Action and Its Disturbances in Disease - part 3 ppsx
... Obesity, insulin resistance 64 Other knockout mice TNFα (−/−) Increased insulin sensitivity 65 TNFα receptor (−/−) Increased insulin sensitivity 66 Adiponectin/ACRP30 (−/−) Increased insulin resistance ... (PHAS-1) are in uenced by insulin. PHAS-1 binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of PHAS-1 and favours dissociation of eIF-4E and PH...
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Insulin Action and Its Disturbances in Disease - part 4 ppsx
... skeletal muscle in non -insulin- dependent diabetes mellitus. J Clin Invest 94, 2349–23 56. 65 . Shulman, G. I. (2000) Cellular mechanisms of insulin resistance. J Clin Invest 1 06, 171–1 76. 66 . Zierath, ... by epinephrine in man. J Clin Invest 46, 86 94. 172 INSULIN RESISTANCE IN GLUCOSE DISPOSAL AND PRODUCTION IN MAN translocation. Although hepatic insulin resistance ma...
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Insulin Action and Its Disturbances in Disease - part 3 pptx
... (eIF-4E), eIF-4G and phospho- rylated heat–acid-stable protein (PHAS-1) are in uenced by insulin. PHAS-1 binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of PHAS-1 and ... 63 9 64 9. 36. Tsakiridis, T., Taha, C., Grinstein, S. and Klip, A. (19 96) Insulin activates a p2 1- activated kinase in muscle cells via phosphatidylinositol 3-kinase. JBiolChem...
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Insulin Action and Its Disturbances in Disease - part 4 pdf
... the renin–angiotensin system (RAS), plasminogen activator inhibitor-1 (PAI-1) and more recently omentin and visfatin. 79 TheroleofTNF-α, leptin, Il -6 , resistin and adiponectin in linking obesity ... acids and inhibits pancreatic insulin secretion. 10 11β-HSD AND OBESITY 219 11β-HSD2, a 405-amino-acid protein, is encoded for on chromosome 16, and is localized to tissue expres...
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Insulin Action and Its Disturbances in Disease - part 5 pptx
... resistin levels in obesity. 209 The resistin mRNA encodes a 114-amino-acid polypeptide containing a 20-amino-acid signal sequence. The secreted protein, resistin, is a 94-amino-acid disulfide-linked ... depend in part on activation of phosphatidyl inositol-3-kinase down- stream from IRS1 and 2. However, a second pathway, involving interaction of the tyrosine kinase cCbl with the insul...
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Insulin Action and Its Disturbances in Disease - part 8 pdf
... TNF-α. 227 TNF-α has also been proposed to link obesity with insulin resistance, with serine phospho- rylation of the insulin receptor substrate-1 being a prominent mechanism for TNF-α-induced insulin ... Kral, J. G. and Lebovitz, H. E. (1995) Does intra-abdominal adipose tissue in black men determine whether NIDDM is insulin- resistant or insulin- sensitive? Diabetes 44, 141–1 4...
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Insulin Action and Its Disturbances in Disease - part 9 pot
... within myocytes. This accumulation triggers PKC and IKK- β-mediated serine phosphorylation of IRS-1, inhibiting insulin- induced tyrosine phosphorylation of IRS-1 and IRS-1-associated PI3-kinase ... D-chiro-inositol-containing phosphoglycans that mediate insulin action, the administration of this substance could improve insulin sensitivity. According to this hypothesis D-chiro-inosi...
Ngày tải lên: 09/08/2014, 15:20
Insulin Action and Its Disturbances in Disease - part 10 ppt
... Relationship to insulin resistance. J Clin Invest 97, 1111–11 16. 159. Hotamisligil, G. S. et al. (19 96) IRS-1-mediated inhibition of insulin receptor tyro- sine kinase activity in TNF- - and obesity-induced ... subcutaneous and visceral depots 215 adipocytokines 245–8, 4 76 adipogenesis 271 adipokines 66 , 269 –70, 269 , 280 insulin resistance 272 adiponectin 279–80 interl...
Ngày tải lên: 09/08/2014, 15:20