Insulin Action and Its Disturbances in Disease - part 5 pptx
Insulin Action and Its Disturbances in Disease - part 5 pptx
... resistin levels in obesity. 209 The resistin mRNA encodes a 114-amino-acid polypeptide containing a 20-amino-acid signal sequence. The secreted protein, resistin, is a 94-amino-acid disulfide-linked ... adipocyte- derived signalling molecule that reduces insulin- stimulated glucose uptake 75 and is found in high concentrations in obese and insulin- resistant individuals. 76, 77 T...
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Insulin Action and Its Disturbances in Disease - part 3 pptx
... (eIF-4E), eIF-4G and phospho- rylated heat–acid-stable protein (PHAS-1) are in uenced by insulin. PHAS-1 binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of PHAS-1 and ... Halliday, D. (19 85) Direct determination of leucine metabolism and protein breakdown in humans using L-( 1- 13 C, 15 N) leucine and forearm model. Eur J Clin Invest 15, 3 45 353...
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Insulin Action and Its Disturbances in Disease - part 2 pptx
... (APS) and SH2-B enhance insulin- receptor autophosphorylation, extracellular-signal-regulated kinase and phosphoinositide 3- kinase-dependent signalling. Biochem J 371, 4 05 412. 94 INSULIN ACTION ON ... hypertriglyceridaemia and insufficient insulin action such as in insulin resistance. The strongest evidence for a link between insulin action and gene transcrip- ti...
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Insulin Action and Its Disturbances in Disease - part 5 doc
... of insulin resis- tance. 149 – 151 Treatment with TZDs to prevent insulin resistance also inhibits the expression and release of leptin. 152 – 155 In both adipocytes and myocytes, basal and insulin ... resistin levels in obesity. 209 The resistin mRNA encodes a 114-amino-acid polypeptide containing a 20-amino-acid signal sequence. The secreted protein, resistin, is a 94-amin...
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Insulin Action and Its Disturbances in Disease - part 7 pptx
... consisting of dietary treatment and/ or increase of PA or training with annual check-ups OGTT – fasting and post-challenge insulin Reduction in 0, 40 min increment, and 2 h insulin during intervention (p<0.0001) ... kcal/day (20% protein, 25% fat, 55 % CHO) Hyperinsulinaemic euglycaemic clamp + QUICKI 38% increase in insulin sensitivity and 8% decrease in QUICKI (p<...
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Insulin Action and Its Disturbances in Disease - part 1 ppsx
... resistance : insulin action and its disturbances in disease / editors, Sudhesh Kumar, Stephen O’Rahilly. p. cm. Includes bibliographical references and index. ISBN 0-4 7 0-8 50 0 8-6 1. Insulin resistance. ... Grb14 gene in mice improves glucose tolerance and enhances insulin signalling in liver and muscle but not fat, confirming Grb14 as a tissue-specific mo...
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Insulin Action and Its Disturbances in Disease - part 4 pdf
... (TNF-α), interleukin-6 (IL- 6), leptin, resistin, the renin–angiotensin system (RAS), plasminogen activator inhibitor-1 (PAI-1) and more recently omentin and visfatin. 79 TheroleofTNF-α, leptin, ... acids and inhibits pancreatic insulin secretion. 10 11β-HSD AND OBESITY 219 11β-HSD2, a 4 0 5- amino-acid protein, is encoded for on chromosome 16, and is localized to tissue expressin...
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Insulin Action and Its Disturbances in Disease - part 6 pps
... insulin action via increased insulin receptor expression and increased activation of insulin receptor kinase. 91 11.4 Summary Whole body insulin sensitivity is the product of a complex interaction ... years BMI: Ethnicity: Chinese (Guangdong Province) MOSPA questionnaire Fasting serum insulin (Fasting insulin resistance index: ‘a multiplication value of fasting insulin and...
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Insulin Action and Its Disturbances in Disease - part 8 pdf
... also been proposed to link obesity with insulin resistance, with serine phospho- rylation of the insulin receptor substrate-1 being a prominent mechanism for TNF-α-induced insulin resistance. 228 Physiologically, ... population-specific environmental factors. PC-1 Plasma cell membrane glycoprotein-1 (PC-1) inhibits insulin receptor (IR) tyro- sine kinase activity and subsequent cellu...
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Insulin Action and Its Disturbances in Disease - part 9 pot
... within myocytes. This accumulation triggers PKC and IKK- β-mediated serine phosphorylation of IRS-1, inhibiting insulin- induced tyrosine phosphorylation of IRS-1 and IRS-1-associated PI3-kinase ... D-chiro-inositol-containing phosphoglycans that mediate insulin action, the administration of this substance could improve insulin sensitivity. According to this hypothesis D-chiro-inosi...
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