Insulin Action and Its Disturbances in Disease - part 5 pptx
Insulin Action and Its Disturbances in Disease - part 5 pptx
... resistin levels in obesity.
209
The resistin mRNA encodes
a 114-amino-acid polypeptide containing a 20-amino-acid signal sequence. The
secreted protein, resistin, is a 94-amino-acid disulfide-linked ... adipocyte-
derived signalling molecule that reduces insulin- stimulated glucose uptake
75
and
is found in high concentrations in obese and insulin- resistant individuals.
76, 77
T...
Insulin Action and Its Disturbances in Disease - part 3 pptx
... (eIF-4E), eIF-4G and phospho-
rylated heat–acid-stable protein (PHAS-1) are in uenced by insulin. PHAS-1
binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of
PHAS-1 and ... Halliday, D. (19 85) Direct
determination of leucine metabolism and protein breakdown in humans using L-( 1-
13
C,
15
N) leucine and forearm model. Eur J Clin Invest 15, 3 45 353...
Insulin Action and Its Disturbances in Disease - part 2 pptx
... (APS) and SH2-B enhance insulin- receptor
autophosphorylation, extracellular-signal-regulated kinase and phosphoinositide 3-
kinase-dependent signalling. Biochem J 371, 4 05 412.
94 INSULIN ACTION ON ... hypertriglyceridaemia and insufficient insulin action
such as in insulin resistance.
The strongest evidence for a link between insulin action and gene transcrip-
ti...
Insulin Action and Its Disturbances in Disease - part 5 doc
... of insulin resis-
tance.
149 – 151
Treatment with TZDs to prevent insulin resistance also inhibits
the expression and release of leptin.
152 – 155
In both adipocytes and myocytes,
basal and insulin ... resistin levels in obesity.
209
The resistin mRNA encodes
a 114-amino-acid polypeptide containing a 20-amino-acid signal sequence. The
secreted protein, resistin, is a 94-amin...
Insulin Action and Its Disturbances in Disease - part 7 pptx
... consisting of
dietary treatment
and/ or increase of
PA or training with
annual check-ups
OGTT – fasting and
post-challenge
insulin
Reduction in 0,
40 min increment,
and 2 h insulin
during
intervention
(p<0.0001) ... kcal/day
(20% protein, 25%
fat, 55 % CHO)
Hyperinsulinaemic
euglycaemic
clamp + QUICKI
38% increase in
insulin sensitivity
and 8% decrease
in QUICKI
(p<...
Insulin Action and Its Disturbances in Disease - part 1 ppsx
... resistance : insulin action and its disturbances in disease / editors, Sudhesh
Kumar, Stephen O’Rahilly.
p. cm.
Includes bibliographical references and index.
ISBN 0-4 7 0-8 50 0 8-6
1. Insulin resistance. ... Grb14 gene in mice improves glucose tolerance
and enhances insulin signalling in liver and muscle but not fat, confirming Grb14
as a tissue-specific mo...
Insulin Action and Its Disturbances in Disease - part 4 pdf
... (TNF-α), interleukin-6 (IL-
6), leptin, resistin, the renin–angiotensin system (RAS), plasminogen activator
inhibitor-1 (PAI-1) and more recently omentin and visfatin.
79
TheroleofTNF-α,
leptin, ... acids and inhibits pancreatic
insulin secretion.
10
11β-HSD AND OBESITY 219
11β-HSD2, a 4 0 5- amino-acid protein, is encoded for on chromosome 16, and
is localized to tissue expressin...
Insulin Action and Its Disturbances in Disease - part 6 pps
... insulin action via increased insulin receptor expression and increased
activation of insulin receptor kinase.
91
11.4 Summary
Whole body insulin sensitivity is the product of a complex interaction ... years
BMI:
Ethnicity: Chinese
(Guangdong Province)
MOSPA
questionnaire
Fasting serum insulin
(Fasting insulin
resistance index: ‘a
multiplication
value of fasting
insulin and...
Insulin Action and Its Disturbances in Disease - part 8 pdf
... also
been proposed to link obesity with insulin resistance, with serine phospho-
rylation of the insulin receptor substrate-1 being a prominent mechanism for
TNF-α-induced insulin resistance.
228
Physiologically, ... population-specific environmental factors.
PC-1
Plasma cell membrane glycoprotein-1 (PC-1) inhibits insulin receptor (IR) tyro-
sine kinase activity and subsequent cellu...
Insulin Action and Its Disturbances in Disease - part 9 pot
... within myocytes. This accumulation triggers PKC and IKK-
β-mediated serine phosphorylation of IRS-1, inhibiting insulin- induced tyrosine
phosphorylation of IRS-1 and IRS-1-associated PI3-kinase ... D-chiro-inositol-containing phosphoglycans that mediate
insulin action, the administration of this substance could improve insulin
sensitivity. According to this hypothesis D-chiro-inosi...
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