Insulin Action and Its Disturbances in Disease - part 4 pdf
Insulin Action and Its Disturbances in Disease - part 4 pdf
... (TNF-α), interleukin-6 (IL-
6), leptin, resistin, the renin–angiotensin system (RAS), plasminogen activator
inhibitor-1 (PAI-1) and more recently omentin and visfatin.
79
TheroleofTNF-α,
leptin, ... acids and inhibits pancreatic
insulin secretion.
10
11β-HSD AND OBESITY 219
11β-HSD2, a 40 5-amino-acid protein, is encoded for on chromosome 16, and
is localized to tissue expressing...
Insulin Action and Its Disturbances in Disease - part 8 pdf
... D., Kral, J. G. and Lebovitz, H. E. (1995)
Does intra-abdominal adipose tissue in black men determine whether NIDDM is insulin-
resistant or insulin- sensitive? Diabetes 44 , 141 – 146 .
16. Albu, J. ... also
been proposed to link obesity with insulin resistance, with serine phospho-
rylation of the insulin receptor substrate-1 being a prominent mechanism for
TNF-α-induced insuli...
Insulin Action and Its Disturbances in Disease - part 4 ppsx
... by
epinephrine in man. J Clin Invest 46 , 86– 94.
172 INSULIN RESISTANCE IN GLUCOSE DISPOSAL AND PRODUCTION IN MAN
translocation. Although hepatic insulin resistance may play only a minor role in
the ... frequency.
45
ICV injection of insulin reduces food intake and
body weight in baboons and rodents
171, 172
and administration of anti -insulin
antibodies into the...
Insulin Action and Its Disturbances in Disease - part 1 ppsx
... resistance : insulin action and its disturbances in disease / editors, Sudhesh
Kumar, Stephen O’Rahilly.
p. cm.
Includes bibliographical references and index.
ISBN 0 -4 7 0-8 500 8-6
1. Insulin resistance. ... the Grb 14 gene in mice improves glucose tolerance
and enhances insulin signalling in liver and muscle but not fat, confirming Grb 14
as a tissue-spec...
Insulin Action and Its Disturbances in Disease - part 3 pptx
... (PHAS-1) are in uenced by insulin. PHAS-1
binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of
PHAS-1 and favours dissociation of eIF-4E and PHAS-1.
14
This allows for
binding ... body protein synthesis in type I (insulin-
dependent) diabetes patients by insulin- plus-glucose during amino acid infusion: studies
of incorporation and turnover of tracer L-...
Insulin Action and Its Disturbances in Disease - part 5 pptx
... resistin levels in obesity.
209
The resistin mRNA encodes
a 1 1 4- amino-acid polypeptide containing a 20-amino-acid signal sequence. The
secreted protein, resistin, is a 9 4- amino-acid disulfide-linked ... resistin expression
in vivo in several different models of obesity and insulin resistance.
84
A further possible link between PPARγ action in adipose tissue and insulin...
Insulin Action and Its Disturbances in Disease - part 6 pps
... insulin action via increased insulin receptor expression and increased
activation of insulin receptor kinase.
91
11 .4 Summary
Whole body insulin sensitivity is the product of a complex interaction ... glucose and insulin responses. This apparent effect on insulin sensitiv-
ity may depend on the underlying individual level of insulin resistance. In a
small study of seve...
Insulin Action and Its Disturbances in Disease - part 9 pot
... within myocytes. This accumulation triggers PKC and IKK-
β-mediated serine phosphorylation of IRS-1, inhibiting insulin- induced tyrosine
phosphorylation of IRS-1 and IRS-1-associated PI3-kinase ... abnormality in insulin receptor phos-
phorylation in cells from women with PCOS. Increased insulin- dependent serine
phosphorylation of the insulin receptor β-subunit in skin fibrob...
Insulin Action and Its Disturbances in Disease - part 10 ppt
... Ser307 in insulin receptor substrate-1 blocks
interactions with the insulin receptor and inhibits insulin action. JBiolChem277,
1531–1537.
1 54. Jiang, G., Dallas-Yang, Q., Liu, F., Moller, D. E. and ... Relationship to insulin resistance. J Clin
Invest 97, 1111–1116.
159. Hotamisligil, G. S. et al. (1996) IRS-1-mediated inhibition of insulin receptor tyro-
sine kinase activi...
Insulin Action and Its Disturbances in Disease - part 2 pptx
... extracellular-signal-regulated kinase and phosphoinositide 3-
kinase-dependent signalling. Biochem J 371, 40 5 41 2.
94 INSULIN ACTION ON LIPID METABOLISM
regulation of HSL by insulin is not likely. Instead, ... hypertriglyceridaemia and insufficient insulin action
such as in insulin resistance.
The strongest evidence for a link between insulin action and gene tra...
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