Báo cáo y học: "Rituximab treatment in rheumatoid arthritis: how does it work" pdf

... repopulation was recently shown in the bone marrow as well [6]. Of importance, the long-term reduction of Editorial Rituximab treatment in rheumatoid arthritis: how does it work? Maria JH Boumans ... (like antibody-dependent cellular cytotoxicity) are most important in the elimination of circulating B cells as well as lymph node and splenic follicular B cells [4]. Treatment...

Ngày tải lên: 09/08/2014, 14:22

... Arthritis with Concomitant Therapy Study Group: Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant ... times during 78 weeks of infliximab therapy as determined by (a) Disease Activity Score (DAS 28) and (b) serum C-reactive protein levelsChanges in disease activity in 30 patients with...

Ngày tải lên: 09/08/2014, 01:23

... the cytokine network in such induction has already been demonstrated for another cytokine, interferon γ, inducing the development of autoan- tibodies in patients with hepatitis C viral infection ... Access Available online http://arthritis-research.com/content/6/6/R535 R535 Vol 6 No 6 Research article Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced speci...

Ngày tải lên: 09/08/2014, 01:24

... important in retaining the cells at this site [17,18]. In about 20% of patients with RA, infiltrating T and B lym- phocytes accumulate underneath the synovial lining layer and organize into lymphocyte ... predominant infiltrate the inflamed synovium, is consistent with their highly dif- ferentiated state [11–16]. These inflammatory chemokine receptors are prominently expressed on effector...

Ngày tải lên: 09/08/2014, 03:24

... DRB1 In the initial, retrospective study, the frequency of B cells was determined as a percentage of CD19 + lymphocytes from total T lymphocytes and B lymphocytes combined (CD3 + + CD19 + lymphocytes). ... homeostasis in RA reported here has not been described previously. The clinical relevance of B lymphocytopenia in SE-positive RA will be further investigated in longitudinal studies...

Ngày tải lên: 09/08/2014, 03:24

... above). It is tempting to speculate that chronic production of cytokines, including TNF-α, may affect the myocardium in RA in either an endocrine (originating in the synovium) or paracrine (produced in ... with RA [106], the complex relationship of RA-induced and RA therapy-induced hyperhomocysteinemia to CHF risk in RA has yet to be completely elucidated. Inflammatory cytokines...

Ngày tải lên: 09/08/2014, 07:20

... 3 Probability plot: change/year in total radiographic scoreProbability plot: change/year in total radiographic score. Figure 4 Probability plot: change/year in erosion scoreProbability plot: change/year ... A, et al.: Min- imal clinically important difference in radiological progression of joint damage over 1 year in rheumatoid arthritis: preliminary results of a validation stud...

Ngày tải lên: 09/08/2014, 08:22

... modifications by showing that treatment with the HDAC inhibitor trichostatin A induces apoptosis in RASFs, while concomitantly FLIP (Flice inhibitory protein) was found to be silenced [30]. Inherited retroviral sequences ... primary transcripts within an alternative (mirtronic) pathway by splicing and debranching. Finally, from the resulting miRNA duplex, the strand with the higher affini...

Ngày tải lên: 09/08/2014, 13:21

... fungus growing in a cavity, in the lung or a sinus, often a maxillary sinus. Aspergilloma has been found in 3.7% of patients under- going surgery for chronic inflammatory sinusitis [12]. Sinus aspergilloma ... therapy Recovery [44] Aspergilloma Lung Ankylosing spondylitis ? Recovery [45] Aspergilloma Lung Ankylosing spondylitis ? ? [46] Aspergilloma (× 2) Lung Ankylosing spondylitis...

Ngày tải lên: 09/08/2014, 14:22

... analysis [37]. Ideally, future work could focus on whether it is the impact of discrete pathology, such as IM or SM bursal hypertrophy, MTP joint synovial hypertrophy or tenosynovitis that may ... rheumatoid arthritis. Rheumatol Int 2005, 26:42-47. 12. Rosenbaum D, Schmiegel A, Meermeier M, Gaubitz M: Plantar sensitivity, foot loading and walking pain in rheumatoid arthritis. Rheu...

Ngày tải lên: 10/08/2014, 21:24