Báo cáo y học: "Sinus aspergilloma in rheumatoid arthritis before or during tumor necrosis factor-alpha antagonist therapy" ppsx
Báo cáo y học: "Sinus aspergilloma in rheumatoid arthritis before or during tumor necrosis factor-alpha antagonist therapy" ppsx
... found in 3.7% of patients under-going surgery for chronic inflammatory sinusitis [12].Sinus aspergilloma is often asymptomatic and may thereforebe overlooked during the workup performed before ... carried out in the PubMed data-base, using the following keywords: (rheumatoid arthritis OR ankylosing spondylitis OR spondylarthritis) AND (aspergilloma OR fungus ball OR aspergillosis OR sinusitis). ... imaging wasperformed [10]. In our study, CT of the sinuses was performedonly to investigate symptoms. Sinus aspergilloma may remainasymptomatic for several years, however, and may thereforebe...
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Báo cáo y học: " Autoantibody profile in rheumatoid arthritis during long-term infliximab treatment" pdf
... Concomitant Therapy Study Group: Infliximaband methotrexate in the treatment of rheumatoid arthritis. Anti -tumor necrosis factor trial in rheumatoid arthritis withconcomitant therapy Study Group. N ... Tak PP: Tumor necrosis fac-tor alpha blockade reduces the synovial cell infiltrate earlyafter initiation of treatment, but apparently not by induction ofapoptosis in synovial tissue. Arthritis ... antibody assays in early rheumatoid arthritis for predicting five years radiographic damage. Ann Rheum Dis2003, 62:120-126.19. Bas S, Genevay S, Meyer O, Gabay C: Anti-cyclic citrullinatedpeptide...
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Báo cáo y học: "Homing chemokines in rheumatoid arthritis" doc
... highly dif-ferentiated state [11–16]. These inflammatorychemokine receptors are prominently expressed oneffector T lymphocytes (Th1 cells) that mediate a type 1inflammation such as RA. Interestingly, ... underneath the synovial lining layerand organize into lymphocyte aggregates with germinalcentres (GCs) [19–21]. These ectopic lymphoid struc-tures share many features with secondary lymphoid tissueand ... [33]. Lymphoid neogenesis isnot only observed in RA, but also in several other chronicinflammatory diseases including Helicobacter pylori gastri-tis, Sjögren’s syndrome, Hashimoto’s thyroiditis...
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Báo cáo y học: "B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response" docx
... DRB1 In the initial, retrospective study, the frequency of B cellswas determined as a percentage of CD19+lymphocytesfrom total T lymphocytes and B lymphocytes combined(CD3++ CD19+lymphocytes). ... subsequent binding to Fc receptors in rodenterosive polyarthritis models resembling RA [13].RF production in RA is thought to occur in the synovialinfiltrate in affected joints, which contains follicular ... stimulatory interactions between theB-cell surface receptor B lymphocyte stimulator (BlyS) andthe transmembrane activator and CAML interactor (TACI)[33] has also recently been reported to...
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Báo cáo y học: "Myocardial dysfunction in rheumatoid arthritis: epidemiology and pathogenesis" pps
... RA-induced and RA therapy-inducedhyperhomocysteinemia to CHF risk in RA has yet to becompletely elucidated.Inflammatory cytokines In patients with overt CHF, levels of inflammatory cytokines(TNF-α, ... istempting to speculate that chronic production of cytokines,including TNF-α, may affect the myocardium in RA in either anendocrine (originating in the synovium) or paracrine (produced in the ... Hiramori K:Expression of tumor necrosis factor-alpha- converting enzymeand tumor necrosis factor-alpha in human myocarditis. J AmColl Cardiol 2000, 36:1288-1294.Available online http:/ /arthritis- research.com/content/7/5/195197Indeed,...
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Báo cáo y học: "Bone erosions in rheumatoid arthritis can be repaired through reduction in disease activity with conventional disease-modifying antirheumatic drugs." pot
... 3Probability plot: change/year in total radiographic scoreProbability plot: change/year in total radiographic score.Figure 4Probability plot: change/year in erosion scoreProbability plot: change/year ... LindenS: Reading radiographs in chronological order, in pairs or assingle films has important implications for the discriminativepower of rheumatoid arthritis clinical trials. Rheumatology(Oxford) ... A, et al.: Min-imal clinically important difference in radiological progressionof joint damage over 1 year in rheumatoid arthritis: preliminaryresults of a validation study with clinical experts....
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Báo cáo y học: "Epigenetic modifications in rheumatoid arthritis" pptx
... regions. Methyl CpG-bindingproteins use transcriptional corepressors for transcriptionalsilencing or may modify the surrounding chromatin ofmethylated regions [27]. In oncogenesis, hypermethylation ... modifications regulatinginflammatory processesThe transcription factor NF-κB plays a central role in theinduction of genes involved in immunity and inflammation,including cytokines, chemokines, adhesion ... genomichypomethylation in RASFs. In accordance, very recent datastrongly support the hypothesis that genomichypomethylation might play a key role in the pathogenesis ofthe activated phenotype of RASFs, in particular...
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Báo cáo y học: "Rituximab treatment in rheumatoid arthritis: how does it work" pdf
... plasma cells, in the inflamed synovium; andexperimental studies showing, for instance, the effects ofimmune complexes containing rheumatoid factor on tumor necrosis factor production by macrophages. ... B cell populations in RA patientsthat usually lasts for 6 to 9 months. Repopulation occursmainly by naïve B cells, whereas memory B cells can staydepleted for more than 2 years [5]. The same ... monoclonal antibody (rituximab or 2H7),complement-dependent cytotoxicity plays a dominant role in B cell depletion in the splenic marginal zone B cell compart-ment, whereas Fc receptor mediated mechanisms...
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Báo cáo y học: " Forefoot pathology in rheumatoid arthritis identified with ultrasound may not localise to areas of highest pressure: cohort observations at baseline and twelve months" ppt
... limitation may be rectified using Magnetic Resonance Imaging to delineate the soft tissue structures. Finally, for pragmatic analysis we categorised the forefoot nominally into either medial or lateral ... foot-shoe interface pressures is increasingly used in clinical practice to determine clinical interventions, such as foot orthoses, for patients with RA, yet there is very little evidence for this ... MTP joint synovial hypertrophy and forefoot bursal hypertrophy within the forefoot is variable in over half our participants. Correlations of US detectable forefoot pathology and peak forefoot...
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Báo cáo y học: "Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study" ppsx
... USA: Theodore Pincus, VanderbiltUniversity, Nashville, TN; Yusuf Yazici, NYU Hospital for JointDiseases, New York, NY; Martin Bergman, Taylor Hospital,Ridley Park, PA; Christopher Swearingen, ... Theodore Pincus, New York University Hospitalfor Joint Diseases, New York, NY, USA.AcknowledgementsAbbott Laboratories (Abbott Park, IL, USA) provided financial support for this study. The ... unfavorablefor females; tumor necrosis factor inhibitors alter sex hormonemetabolism in the synovial tissue [61]. The beneficial effectsinclude restored levels of synovial androgens althoughrestored...
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