Báo cáo y học: "Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial" pot

... article Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 ... adiponectin concentrations correlate with the severity of RA evaluated by the extent of joint destruc- tion, indirectly suggesting that adiponectin may...

Ngày tải lên: 09/08/2014, 14:22

... K: Interleukin-18 and interleukin-12 synergize to stimulate the production of vascular permeability factor by T lymphocytes in normal subjects and in patients with minimal-change nephrotic syndrome. ... AJ: Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha- ras-transformed cells through...

Ngày tải lên: 09/08/2014, 01:21

... these cells in the inflamed synovia and that blocking the effects of TNF decreases trafficking into and retention of B cells in the synovia, thereby increasing their proportion in the peripheral ... Dutcher PO, Hadley JA, Sanz I: Cutting edge: anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid ger- minal centres an...

Ngày tải lên: 09/08/2014, 14:22

... citrullinated proteins in synovial membranesLocalisation of citrullinated proteins in synovial membranes. (a) Immunostaining of citrullinated proteins by the anti-modified citrulline kit was mainly ... Finally the slides were counterstained for 1 minute with haematoxylin, washed in tap water, dehydrated, cleared and mounted. Figure 1 Screen to identify undeiminated and deiminate...

Ngày tải lên: 09/08/2014, 07:20

... focusing on the genes in the region, to identify polymorphisms that may contribute to susceptibility to RA and potentially to other autoimmune diseases. Validated single nucleotide polymorphisms (SNPs; ... beta type 1; PTPN22 = protein tyrosine phosphatase N22; RA = rheumatoid arthritis; RF = rheumatoid factor; SLE = systemic lupus erythematosus; SNP = single nucle- otid...

Ngày tải lên: 09/08/2014, 08:22

... found in all the stained RA synovial biopsies. FcγRIIb staining was observed in the synovial lin- ing and sub-lining layers, perivasculary and inside lymphocyte infiltrates (e). (d) No staining ... cells and B cells. Cross-linking of FcγRs by IgG-ICs leads to cellular effector functions such as phagocy- tosis, antibody-dependent cellular toxicity and release of inflammatory...

Ngày tải lên: 09/08/2014, 10:20

... irreversibly altered [1] or reversibly stimulated by the inflammatory microenvironment [2], are major compo- nents of the pannus and contribute to joint destruction by secretion of pro-inflammatory cytokines ... Cheon H, Yu SJ, Yoo DH, Chae IJ, Song GG, Sohn J: Increased expression of pro-inflammatory cytokines and metalloprotein- ase-1 by TGF-beta1 in synovial fibroblasts...

Ngày tải lên: 09/08/2014, 10:20

... and synovial fluid was analysed by four-colour flow cytometry (FACSCalibur instrument; Becton Dickinson Immunocytome- try Systems, San Jose, CA, USA) in peripheral blood mononu- clear cells and synovial ... con- tributed to the clinical evaluations of patients and manuscript preparation. VM and CT were the principle investigators and participated equally in the planning and...

Ngày tải lên: 09/08/2014, 10:21

... purposes) Arthritis Research & Therapy Vol 9 No 5 Ahnert and Kirsten discernible by current scores and laboratory parameters. If a genetic variant is relevant in only some subtypes (defined by sex, ... al.: Dense genome-wide linkage analysis of rheumatoid arthritis, including covariates. Arthritis Rheum 2004, 50:2757-2765. 3. Horton MA: The αα v ββ 3 integrin ‘vitronect...

Ngày tải lên: 09/08/2014, 10:21

... the proinflammatory load in rheumatoid arthritis Rainer H Straub 1 and Joachim R Kalden 2 1 Laboratory of Experimental Rheumatology and Neuroendocrino-Immunology, Division of Rheumatology, Department ... noradrenaline (via β 2 -adrenoceptors at 10 –6 M) and cortisol (via glucocorticoid receptor α) exert many anti-inflammatory effects. Today we know that both proinflammatory and...

Ngày tải lên: 09/08/2014, 14:21