Báo cáo y học: "Immunocytokines: the long awaited therapeutic magic bullet in rheumatoid arthritis" ppsx

... signaling? Unfortunately, they did not include in their studies the therapeutic impact of the targeting antibody alone, without Editorial Immunocytokines: the long awaited therapeutic magic bullet ... against a specific target fused to a cytokine, thus retaining the functions of both the antibody and the cytokine. In cancer, the use of single-chain antibody fragm...

Ngày tải lên: 09/08/2014, 14:22

... of infliximab therapy Of the initial 511 patients enrolled in the study, 507 effectively started infliximab therapy. All patients had long- standing, active, refractory RA, which is reflected by ... rheumatologist had the option of increasing the dos- age by 100 mg [11,12]. The standard infliximab dosage of 3 mg/kg every 8 weeks was reinstituted in a majority of patients beginn...

Ngày tải lên: 09/08/2014, 08:22

... rather effectively alleviating the symp- toms related to the inflammatory process, most disease- modifying antirheumatic drugs used until very recently have been less effective in retarding the ... and the intra-assay and inter-assay coefficient of variation is <5%. The assay is not influenced by rheuma- toid factors. The serum concentrations of COMP obtained by this assay ar...

Ngày tải lên: 09/08/2014, 01:21

... novel therapeutic avenue for targeting the underlying pathology not only in RA but also possibly in other autoimmune diseases. Competing interests The author(s) declare that they have no competing ... neuropeptides, bombesin/gastrin-releasing peptide and substance P, and the proinflammatory cytokine interleukin-6 as well as the erythrocyte sedimentation rate. These findings prov...

Ngày tải lên: 09/08/2014, 06:23

... The finding that E-cadherin and collagen type IV are expressed in the lining layer of healthy and arthritic synovium indicates that these lining cells display an epithelial-like phenotype. In addition, ... readily detectable in the lining layer of healthy syn- ovium, seemingly forming a layer underneath the synovial lining cells [31]. Although some mesenchymal markers, such as v...

Ngày tải lên: 09/08/2014, 08:23

... Specifically, the proteins were separated by IEF in the range from pH 4 to 7. Then, the separated proteins were fur- ther separated by their molecular weights by SDS-PAGE. The separated proteins were ... roles in destroying syno- vial tissue and cartilage matrix [30,31]. It is interesting whether citrullination affects the functions of cathepsin D. The third is histamine, a cl...

Ngày tải lên: 09/08/2014, 08:23

... Reduction of inflammation using anti-TNF therapy in RA is rapidly (although transiently) followed by improvement of the endothelial function [8]. Interestingly, high-grade systemic inflammation also ... is highly dependent upon current levels of inflammation. In healthy people, the inflammatory response elicited by vaccination is sufficient to temporarily (and reversibly) impair endot...

Ngày tải lên: 09/08/2014, 10:22

... (median oxygen tension 3%, 26 mmHg) than either noninvasive tenosynovium or joint synovium in the same RA patients, suggesting that hypoxia might be driving invasion of tendon by the synovial tis- sue, ... tenosynovium is more hypoxic than noninva- sive synovium from the same patients [12], we hypothesised that hypoxia drives angiogenesis and/or synovial invasion. In the present s...

Ngày tải lên: 09/08/2014, 14:20

... present in RA and OA synovium, with 5-LO being mostly expressed in lining and sublining macrophages, neutrophils and mast cells and 15-LO-1 mainly in lining macrophages, fibroblasts and sublining ... of joint inflammation and destruction in RA, the present study suggests the use of 5-LO inhibitors as add-on therapy. Competing interests The authors declare that they have no compe...

Ngày tải lên: 09/08/2014, 14:21

... resulted in an enzyme with slightly lower stability. On the other hand, in the double mutant G261A /Y2 69A the additional replacement of Tyr269 by Ala restores the stability of the protein producing ... efficiency of the enzyme, the cold adaptation of the enzyme could not be attributed to the presence of the Gly cluster in this element. The present study supports t...

Ngày tải lên: 22/02/2014, 04:20