Báo cáo y học: "Positive anti-citrullinated protein antibody

Báo cáo y học: "Positive anti-citrullinated protein antibody status and small joint arthritis are consistent predictors of chronic disease in patients with very early arthritis: results from the NOR-VEAC cohort" pot

... article Positive anti-citrullinated protein antibody status and small joint arthritis are consistent predictors of chronic disease in patients with very early arthritis: results from the NOR-VEAC cohort Maria ... presence of joint swelling in either metacarpo-phalangeal joint (MCP), proximal interphalangeal joint (PIP), or metatarso-ph...

Ngày tải lên : 09/08/2014, 14:22

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Báo cáo y học: "Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients" doc

... underlying disease and furthermore on the clinical symptoms. Interestingly, the majority of patients showed reactivity to only one of the two major autoantigens. Only 37.1% of anti-PM/Scl-positive patients ... anti-PM/Scl-75-positive patients but in only 32.7% of the patients without this antibody (P = 0.023). In line with this, 62.1% of the anti-PM/Scl...

Ngày tải lên : 09/08/2014, 01:22

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Báo cáo y học: "The spliceosomal autoantigen heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) is a major T cell autoantigen in patients with systemic lupus erythematosus" potx

... nuclear ribonucleoprotein A2 (hnRNP-A2), which occur in 20% to 30% of SLE patients as well as in animal models of this disease. To investigate the underlying cellular reactivity and to gain further insight into ... assays. KS prepared the recombinant antigen. BJS participated in the design of the study. JS and GS conceived of the study, participated in its des...

Ngày tải lên : 09/08/2014, 08:22

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Báo cáo y học: "Vaccination response to tetanus toxoid and 23-valent pneumococcal vaccines following administration of a single dose of abatacept: a randomized, open-label, parallel group study in healthy subjects" pot

... group and the study day as factors and the log of the baseline (prevaccination) antibody level as the covariate. For each antibody, point estimates and 95% confidence intervals for the prevaccination ... prevaccination to postvaccination antibody levels. These con- structions were from the results of repeated-measures analyses of covariance on the natural...

Ngày tải lên : 09/08/2014, 10:20

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Báo cáo Y học: Probing intermolecular protein–protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET) potx

... alternate interpretation of the lack of agonist-induced BRET observed in this study is that the translation of agonist binding to the ATDs of the family C GPCR homodimer into G -protein coupling of the ... the ATDs of the CaR homodimer. Further investigations into the signal transference from the ATDs to the G -protein coupling areas of the receptor h...

Ngày tải lên : 08/03/2014, 09:20

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Báo cáo Y học: A b-lysine adenylating enzyme and a b-lysine binding protein involved in poly b-lysine chain assembly in nourseothricin synthesis in Streptomyces noursei pot

... Molecular characterization of the genes of actinomycin synthetase I and a 4-methyl-3-hydroxyanthranilic acid carrier protein involved in the assembly of the acylpeptide chain of actinomycin in Streptomyces. J. ... reactions involve the partici- pation of only one single stand-alone A-domain and a single binding protein NspB points to an iteration of these two p...

Ngày tải lên : 17/03/2014, 17:20

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Báo cáo Y học: SF2/ASF protein inhibits camptothecin-induced DNA cleavage by human topoisomerase I potx

... both the unmodi- fied and phosphorylated form of the protein. This observation is consistent with findings showing that the interaction of SF2/ASF with htopo I uses the RS domain of this protein and ... reaction catalysed by the enzyme. The first mechanism has been revealed as underlying the inhibition of camptothecin-induced DNA cleavage by ATP [5]. On the o...

Ngày tải lên : 24/03/2014, 03:21

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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx

... to the mechanism underlying protein stability at the amino-acid level. The molecular mechanisms underlying protein maturation, folding, and stability in bacterial cytochromes c are beginning ... FOR PROTEIN STABILITY STUDIES Proteins isolated from thermophilic bacteria are usually stable to heat and chemical denaturants, indicating that they must have most of the d...

Ngày tải lên : 24/03/2014, 03:21

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Báo cáo Y học: Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression pdf

... phosphorylate and regulate numerous targets in the cytoplasm and in the nucleus, including other protein kinases, transcription factors, cytoskeletal proteins, g rowth factor r eceptors, and other ... pathways. As the major signaling event evoked by NGF in many cell types, including SN56T17, is the activation of mitogen-activated p rotein kinase (MAPK), we investigated...

Ngày tải lên : 31/03/2014, 21:21

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Báo cáo Y học: LRP130, a protein containing nine pentatricopeptide repeat motifs, interacts with a single-stranded cytosine-rich sequence of mouse hypervariable minisatellite Pc-1 docx

... unresolved, these ﬁndings led us to the possibility that maintenance of MN integrity is partly regulated by DNA-PK, and changes in the phosphorylation status in cellular proteins could cause the induction ... fractionation analysis. Left and right panels indicate the immunoblot analysis using aF-N and aF-C, respectively. The positions of the protein standard are...

Ngày tải lên : 31/03/2014, 23:20

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