Báo cáo y học: "Preclinical characterization of DEKAVIL (F8-

Báo cáo y học: "Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis" ppsx

... investigation of F8-IL10 as a novel biopharmaceu- tical for the therapy of patients with rheumatoid arthritis who have failed at least two lines of biological therapy. Clinical studies will reveal whether ... immunoreactivity when tested by affinity chromatography on an EDA-sepharose resin (data not shown) and displayed a biological activity compara- ble with that of recombina...

Ngày tải lên : 09/08/2014, 14:22

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Báo cáo y học: "Successful immunotherapy with matrix metalloproteinasederived peptides in adjuvant arthritis depends on the timing of peptide administration" pdf

... were analyzed in lymphocyte prolifera- tion assays at day 0 (naïve animals), day 10 (before clinical onset of disease), day 14 (onset of disease), day 21 (overt Arthritis Research Vol 4 No 4 van ... old at the start of each experiment. This study was approved by the Dutch Committee of Animal Experiments. Induction and clinical evaluation of AA AA was induced by intradermal injec...

Ngày tải lên : 09/08/2014, 03:24

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Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc

... The possibility of alternative specificity is exemplified by the NAALADases, where the primary function appears to be glutamate carboxypeptidase II activity rather than aminodipeptidase functionality. Alternatively, ... factors in the pathogenesis of rheumatoid arthritis? Aleksi Sedo 1 , Jonathan S Duke-Cohan 2 , Eva Balaziova 1 and Liliana R Sedova 3 1 Laboratory of Cancer Cell...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: " TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7" pps

... favoring the catabolic side is very likely involved in the pathological fea- tures of OA. Currently, many attempts are being made to repair the cartilage that has been damaged in OA. One approach ... participated in the animal experiments and immunohis- tochemistry, carried out the histological measurements, analyzed the data, and drafted the manuscript. ELV participated i...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: "Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases" ppt

... PCR Human IL-32 Sense 5'-TGAGGAGCAGCACCCAGAGC-3' Antisense 5'-CCGTAGGACTGGAAAGAGGA-3' Human TNFα Sense 5'-GTCTCCTACCAGACCAAG-3' Antisense 5'-CAAAGTAGACCTGCCCAGACTC-3' Human ... 5'-TGGGAGTAGACAAGGTACAACCC-3' Mouse IL-1β Sense 5'-CAACCAACAAGTGATATTCTCCATG-3' Antisense 5'-GATCCACACTCTCCAGCTGCA-3' Mouse IL-6 Sense 5'-CACTT...

Ngày tải lên : 09/08/2014, 08:23

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Báo cáo y học: "Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab" ppt

... index (SSI) was defined as the ratio of synovial analyte/synovial albumin divided by the ratio of serum analyte/serum albumin. Open Access Available online http://arthritis-research.com/content/10/5/R105 Page ... antibody synthesis to the pathogenesis of RA, their applicability in interventional biopsy-based clinical tri- als is limited. Synovial tissues obtained by arthroscopy or...

Ngày tải lên : 09/08/2014, 13:21

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Báo cáo y học: "Capturing real-life patient care in psoriatic arthritis and its risks: the challenge of analysing registry data" docx

... patients clearly will have unacceptable flares, and others clearly will have unacceptable toxicity; however, the vast majority of patients will have some combination of the two, which will hamper ... will hamper a clear adjudication of the reason for withdrawal. In summary, the study by Saad and colleagues gives us important insights into daily-life use of TNF inhibitors i...

Ngày tải lên : 09/08/2014, 14:20

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Báo cáo y học: " Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients" pps

... for citation purposes) variate analysis was performed with those parameters selected by univariate analyses with P values less than 0.1. In a second multivariate analysis, only BALF cytokines ... play a major role in SSc-ILD. Despite the possible important role of lymphocyte activation and cytokine release in SSc-ILD, accumulation of lymphocytes in BAL was not predictive of diseas...

Ngày tải lên : 09/08/2014, 14:22

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Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" ppt

... HDAC-2 antibody (Santa Cruz Biotechnology, CA, USA); mSin 3a antibody (Abcam, Cambridge, UK); Mi2α/ β antibody (Austral Biotechnology, San Ramon, CA, USA); Lamin A/ C antibody (Santa Cruz); GAPDH (Abcam). Statistical ... 7:33 http://www.journal-inflammation.com/content/7/1/33 Page 2 of 7 [2,7]. These are used to manipulate the basal transcrip- tional machinery and the chromatin struct...

Ngày tải lên : 11/08/2014, 03:20

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Báo cáo y học: " Part I, Patient perspective: activating patients to engage their providers in the use of evidencebased medicine: a qualitative evaluation of the VA Project to Implement Diuretics (VAPID)" ppsx

... Iowa City, IA, USA. 3 Department of Psychology, University of Iowa, Iowa City, IA, USA. Authors’ contributions SAP participated in the qualitative analysis and prepared the draft of the manuscript. ... collection and thematic content analysis occurring simultaneously; detailed analysis of the thematic codes; a nd matrix analysis of codes. The first stage was an iterati...

Ngày tải lên : 11/08/2014, 05:21

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