Báo cáo y học: "Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro" pptx

... Tumor necrosis factor-a converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation Kristina Endres, Andreas ... mature TACE was inhibited by blocking endocytosis [39] it is possible that the effect of phorbol esters on TACE maturation depends on vesicle formation and endocytosis....

Ngày tải lên: 08/03/2014, 02:20

... Daha MR, Kluin PM, Meinders AE, Tak PP: Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared with patients with Yersinia-induced arthritis and osteoarthritis. ... protein for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis was induced in DBA/1 mice. At the first clinical sign of disease, m...

Ngày tải lên: 09/08/2014, 01:23

... article Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte Aaron R Klooster and Suzanne M Bernier CIHR Group in Skeletal Development and ... induced by epidermal growth factor (EGF)Tumor necrosis factor alpha (TNF-α) enhances elongated cell morphology induced by epidermal...

Ngày tải lên: 09/08/2014, 06:22

... placebo-controlled trial [2] and afterwards Commentary Tumor necrosis factor- αα blockade in ankylosing spondylitis: a potent but expensive anti-inflammatory treatment or true disease modification? Filip Van den ... colleagues seem to indicate that at least for the vast majority of ankylosing spondylitis patients treatment with infliximab can not be withdrawn...

Ngày tải lên: 09/08/2014, 06:23

... anti-inflammatory properties are used in human ther- apy, regulate in vitro CD36 expression. Aspirin increases CD36 expression in lines of human THP1 macrophages [23], dexamethasone induces CD36 expression ... TNFα and adalimumab, a human anti-TNFα monoclonal antibody widely used in human pathology, in CD36 expression in human monocytes. Human monoc...

Ngày tải lên: 09/08/2014, 10:20

... article NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating ... involved in osteoclastogenesisEffect of dehydroxymethylepoxyquinomicin on serum factors involved in osteoclastogenesis. Effec...

Ngày tải lên: 09/08/2014, 10:21

... analysis using splenocytes of mice with GPI-induced arthritis. Expression of TNFα-induced adipose-related protein (TIARP) mRNA and protein in spleens, joints and lymph nodes was evaluated, and fluctuation ... splenocytes. In arthritic mice, TIARP mRNA was expressed mainly in CD11b + cells in the spleen, and TIARP mRNA level was increased in the joints (accompanied...

Ngày tải lên: 09/08/2014, 14:22

... and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro Henning Voigt, Angelika K Lemke, Rolf Mentlein, Michael Schünke and Bodo ... aggre- canase activity might be involved in the early TNFα -mediated aggrecanolysis in the meniscus. Inhibition of aggrecanase activity or TNFα -ac...

Ngày tải lên: 09/08/2014, 14:22

... Open Access Tumor necrosis factor-a enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells Bao-Wei Wang 1,2 , Chiu-Mei Lin 3 , Gong-Jhe ... 14 human CAECs. Since JNK kinase inhibitor reduced the visfatin protein expression most significantly. We then focused on the JNK kinase pathway on the...

Ngày tải lên: 10/08/2014, 05:21

... report Isolated radial head dislocation, a rare and easily missed injury in the presence of major distracting injuries: a case report Ulfin Rethnam*, Rajam SU Yesupalan and Salah S Bastawrous Address: ... of the radial head in an adult. J Orthop Trauma 1995, 9(5):441-4. 5. Yasuwaki Y, Itagane H, Nagata Y, Nishimoto S, Nakano A, Tanaka S: I...

Ngày tải lên: 11/08/2014, 10:22

... of these cells. Density of neutrophils in synovial tissues of patients with OA and RA The presence of HNP1-3 prompted us to study the den- sity of elastase-positive neutrophils in synovial tissues ... defensins from synovial tissue/ cells and density of synovial neutrophils. (a) Levels of human neutrophil pep- tides 1-3 (HNP1-3) in superfusate o...

Ngày tải lên: 12/08/2014, 14:22

... therefore, investigated this proposal and the macrophage signaling pa thways underlying it. Methods: Caspase-3 activity, annexin-V binding/7-aminoactinomycin D (7-AAD) exclusion and cell-cycle analysis were ... and assayed for caspase-3 activity as described previously [20]. Flow cytometry analysis Apoptotic cells were quantitated by staining wit h annexin V-PE and 7-AAD, as specified by...

Ngày tải lên: 12/08/2014, 15:22

... pathway activates Jun-N-terminal kinases and the transcription factor AP-1. The third pathway activates NF-κB, a primary mediator of tran- scriptional control and a major candidate for catabolic signaling. ... pathways mediate the cellular response to TNF -α. One pathway stimulates apoptosis via interaction with the TNF -α- receptor complex and the Fas-associated protein with deat...

Ngày tải lên: 12/08/2014, 18:20

... emphysema, is associated with TNF-α +489G/A gene polymorphism. Keywords: Caucasians, COPD, Gene polymorphism, Susceptibility, Tumor necrosis factor-α Introduction The pro-inflammatory cytokine ... 1 http://respiratory-research.com/content/3/1/29 Kỹỗỹkaycan et al. Research article Tumor Necrosis Factor- +489G/A gene polymorphism is associated with chronic...

Ngày tải lên: 12/08/2014, 18:20

Ngày tải lên: 13/08/2014, 20:21