Báo cáo y học: "Anti-tumour necrosis factor therapy and B cells in rheumatoid arthritis" pptx

... in the inflamed synovia and < /b> that blocking the effects of TNF decreases trafficking into and < /b> retention of B cells in the synovia, thereby increasing their proportion in the peripheral blood. However, ... Dutcher PO, Hadley JA, Sanz I: Cutting edge: anti-tumor necrosis < /b> factor < /b> therapy < /b> in rheumatoid arthritis inhibits memory B lymphocytes via eff...

Ngày tải lên: 09/08/2014, 14:22

... expressed in lining and < /b> sublining macrophages, neutrophils and < /b> mast cells and < /b> 15-LO-1 mainly in lining macrophages, fibroblasts and < /b> sublining endothelial cells. Intraarticular GC treatment resulted in ... indicated LTB 4 to be a negative regulator of bone metabolism by activat- ing osteoclasts and < /b> inhibiting osteoblasts, thus promoting bone degrad...

Ngày tải lên: 09/08/2014, 14:21

... lining of rheumatic joints and < /b> in chondrocytes of oste- oarthritic joints [8]. TNF-α promotes further expression of cytokines and < /b> chemokines by synovial cells and < /b> chondro- cytes, thereby sustaining ... sig- nificantly by co-addition of TNF-α, probably reflecting an increase in chondrocyte number. These results suggest that reduction in aggrecan and < /b> type II...

Ngày tải lên: 09/08/2014, 06:22

... CD36 expression by TNFα and < /b> adalimumab in human monocytes. While TNFα inhibits both CD36 membrane expression and < /b> mRNA expression, an anti-TNFα monoclonal antibody, adali- mumab, independently increases both ... expression on human monocytes is inhibited by TNFα and < /b> independently increased by adalimumab. These data highlight that pro-inflammatory cytokines and < /b> the...

Ngày tải lên: 09/08/2014, 10:20

... with etanercept and < /b> 10 with infliximab. BMD trends favoured TNF blockade but were small and < /b> non-significant. Serum osteocalcin rose and < /b> the resorption marker urinary deoxypyrdinoline decreased. Most ... strong correlation with BMD assessed by dual energy X-ray absorptiometry [13]. In summary, studies like that by Marotte and < /b> colleagues [6] suggest TNF blockade...

Ngày tải lên: 09/08/2014, 10:20

... levels obtained by the original inhibition assay (r values >0.9 in RA samples) (T Saxne and < /b> D Heinegård, unpublished). Samples obtained at baseline and < /b> after 3 and < /b> 6 months of therapy < /b> if available ... dramatically effec- tive in reducing the signs and < /b> symptoms of inflammation was blocking of tumour necrosis < /b> factor < /b> α (TNF-α) [3]. This wa...

Ngày tải lên: 09/08/2014, 01:21

... anti-Sa antibodies by immunoblotting, was originally shown to be present in synovium [2]. Vimentin is an intermediate filament that is widely expressed in mesenchymal cells and < /b> macrophages, and < /b> is ... antibodies directed against antigens containing the non-standard amino acid citrulline (reviewed in [9]). Citrulline is generated by the post- translational deimination of...

Ngày tải lên: 09/08/2014, 01:23

... tissueHaematoxylin and < /b> eosin staining on healthy and < /b> arthritic synovial tissue. Haematoxylin and < /b> eosin staining was performed on synovial biopsies from (a) healthy subjects and < /b> (b) Rheumatoid arthritis ... actin (α-sma) staining in healthy and < /b> arthritic synovial tissueα-Smooth muscle actin (α-sma) staining in healthy and < /b> arthritic synovial tis...

Ngày tải lên: 09/08/2014, 08:23

... (CapZα-1) by enzyme-linked immunosorbent assay (ELISA)Detection of the autoantibodies to citrullinated or non-citrullinated F-actin capping protein α-1 subunit (CapZα-1) by enzyme-linked immunosorbent ... Specifically, we recovered peptides from the 30 protein spots after in- gel digestion by trypsin, then measured masses of them by MALDI-TOF MS, and < /b> finally searched the NCBI protein...

Ngày tải lên: 09/08/2014, 08:23

... in RA ST fibroblasts and < /b> MΦs at baseline and < /b> was further increased by TNFα or IL1β stimulation. pPaxillin and < /b> pPLCγ were upregulated in RA versus OA and < /b> ND lining cells and < /b> sublining MΦs. Activation ... was significantly higher in RA ST lining and < /b> sublining compared to that of OA and < /b> ND. Rarely, RA patients showed positive immu- nostain...

Ngày tải lên: 09/08/2014, 10:21