Báo cáo y học: "Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells" doc

... No 5 Research article Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells Sybille Franke 1 , Manfred Sommer 1 , ... incorporated into cultured FLS and induced to cell cycle arrest, decreased cell proliferation and viability, but also increased expression of RAGE, NFκB p65...

Ngày tải lên: 09/08/2014, 14:22

... been well documented that both endogenous in ammatory mediator advanced glycation end products (AGEs) and exogenous in ammatory inducer lipopolysaccharide play key roles in the initiation and development of ... lipopolysaccharide cooperatively induce proinflam- matory cytokine ⁄ chemokine production by activating mitogen-activated protein kinases and nuclear factor-jB in en...

Ngày tải lên: 30/03/2014, 01:20

... is induced by AGE, can contribute to the inflammatory cycle by the induction of proinflammatory cytokines, via the nuclear factor-κB pathway [21]. No studies have yet examined RAGE expression in ... with inflammatory arthritis of duration less than 1 year. Patients were evaluated clinically and serologically, and radiographs were obtained at initial and 1-year visits. Sera were as...

Ngày tải lên: 09/08/2014, 01:21

... that pyridoxine may be the precursor of the pyrimidine moiety of thiamin in yeast is intriguing [27]. In fungi, pyroA and SOR1 (PDX1), homologues of yeast SNZ1, play a defensive role against reactive oxygen ... aminated intermediate. These two components eventually undergo coupling and cycliza- tion to form 2¢-hydroxypyridoxine. If this scheme holds, the synthetic pathways to pyridoxi...

Ngày tải lên: 19/02/2014, 12:20

... employment, respectively. In the ability to live independently, 1 means never lived independently, 2 means occasionally lived independently, 3 means none of the items mentioned in scale 5 despite assistance ... community, within their families, lacking significant improvement in clinical as well as social func- tions. They were continuing treatment and did not require any prolonged st...

Ngày tải lên: 08/08/2014, 23:21

... COX-1 and COX-2 [17,18]. COX-1 is expressed constitutively in various cells and tissues, and is important in maintaining homeostasis. In contrast, COX-2 is induced in inflammatory cells and tissues ... by various stimuli includ- ing cytokines, suggesting that COX-2 has a key role in the process of inflammation. Increased PGE 2 production in response to stimulation by pro...

Ngày tải lên: 09/08/2014, 01:23

... Dako), rinsed in distilled water and incu- bated in fast-DAB (3,3'-diaminobenzidine) peroxidase substrate (Sigma) for 5 minutes and counterstained in diluted filtered haematoxylin (Sigma) ... (markers for mesenchymal stem cells), and for CD29 (β1 integrin). The cells stained poorly for LNGFR and STRO-1 (markers on freshly isolated bone marrow stem cells) and sparsely for...

Ngày tải lên: 09/08/2014, 10:20

... lymphocytes in both mice and humans, despite having no notable action on B-lym- phocyte proliferation [1]. It also suppressed inflammatory cytokine production in cultured human synovial cells induced by ... was indicated by increased edema and erythema of one or both ankle joints, followed by involve- ment of the metatarsal and interphalangeal joints. Fully devel- oped arthritis,...

Ngày tải lên: 09/08/2014, 13:22

... multifaceted nature of pain in RA. Physicians and researchers should consider both inflamma- tory and non-inflammatory factors when evaluating pain in research settings and in the clinic. Future studies ... pain sensitivity, as noted in central pain conditions such as fibromyalgia. Future studies examining pain sensitivity at joint and non-joint sites may identify patients wit...

Ngày tải lên: 09/08/2014, 14:22

... AK was involved in manuscript writing and data analysis. SL was involved in the conception and design, administrative support, data analysis and interpretation, manuscript writing and final approval ... acts by reducing the oxidized methionine sulfoxide in proteins back to sulfide and by reducing the cellular level of reactive oxygen species. MsrA, the only enzyme in the Msr...

Ngày tải lên: 10/08/2014, 05:21