Báo cáo y học: "Androgens in rheumatoid arthritis: when are they effectors" ppt

... to a synthetic blockade of the second step of the enzyme P450c17, again induced by inflammatory cytokines such as IL1β and TNF. Increased DHEAS levels during treatment with TNF antagonists in active ... anti-inflammatory activities, are significantly decreased in inflamed tissues (that is, synovial fluid) during active RA in both male and female patients, which supports a pro-inflamma...

Ngày tải lên: 09/08/2014, 14:22

... homology to other HA-binding link proteins. The two basic clusters (gray segments in Fig. 1A, inset a) are involved in HA binding: the first (located inside the link module and overlapping the ... to HA binding are also shown in Fig. 1A, inset a. Cys-266 in the transmembrane domain (Fig. 1A, inset b) is important for HA binding in Jurkat cells. Cys-266 and Cys-275 can be used fo...

Ngày tải lên: 09/08/2014, 01:21

... cause proteins to become non-enzymatically damaged by glyoxidation. This process, which involves primarily lysine and arginine residues, ultimately results in the generation of advanced glycation ... expression in hyper- plastic areas of the RA lining layer would be consistent with a dynamic process in which the lining cells in these areas, being the furthest removed from a precarious...

Ngày tải lên: 09/08/2014, 01:24

... mg/week in the original Table 2 Treatment terminations for ineffectiveness in original and re-employed methotrexate therapies Re-employed course Total No inefficacy Inefficacy Original course No inefficacy ... strategies in the care for RA patients. Competing interests The authors declare that they have no competing interests. Authors' contributions TK, JS and DA were involved i...

Ngày tải lên: 09/08/2014, 07:20

... fluorescein isothiocyanate- conjugated anti-mouse antisera for 30 minutes at 4°C. Stained cells were fixed and 1 × 10 4 viable cells were analysed by flow cytometry using standard settings. Induction ... G 2 / M phase, indicating that the cell population remained highly synchronised. Cell cycle analysis after 42 and 48 hours confirmed an increase of RASFs in G 0 /G 1 phase, indicating tha...

Ngày tải lên: 09/08/2014, 01:22

... Ceuppens JL, Luyten FP: Bone morpho- genetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. ... generally demonstrated blunted T- cell function and surprisingly limited cytokine production compared with other T-cell-mediated diseases. The lympho- cyte cytokine profile in chr...

Ngày tải lên: 09/08/2014, 06:23

... ultimately, of the upregulation of proinflammatory cyto- kines [19,20]. By whichever means they themselves become activated, they induce a plethora of inflammatory products, including degradative enzymes, ... attention (including joint surgery) and that, with increasing HAQ scores, joint replacement surgery and use of other health care resources increase dramatically [43-45]. Among the ma...

Ngày tải lên: 09/08/2014, 01:22

... indicate that genetic regulation involving the TNF-RII gene may play some role in determining circulating levels in RA. Competing interests The author(s) declare that they have no competing interests. Authors' ... the extracellular domains [11-13] and are derived from the mem- brane bound form by the proteolytic actions of a disintegrin metalloproteinase called TNF-α converting e...

Ngày tải lên: 09/08/2014, 07:20

... ontology (GO) categories are shown. Figure 3 Hematoxylin/eosin staining of the synovial membrane of patients 1 to 7Hematoxylin/eosin staining of the synovial membrane of patients 1 to 7. Original ... with rheumatoid arthritis. This was done by applying microarray technology on multiple synovial biopsies obtained from the same knee joints. In this way the relative levels of intra-patie...

Ngày tải lên: 09/08/2014, 07:20

... physiology and pathology. Introduction In patients with rheumatoid arthritis (RA), joint pathology is mediated by typical changes in the synovial tissue. Hyperpla- sia of the synovial lining layer, infiltration ... purposes) lage by the release of inflammatory cytokines and destructive proteases [2]. Increases in knowledge about inflammatory cytokines and cytokine networks in chroni...

Ngày tải lên: 09/08/2014, 07:20