Báo cáo y học: "Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response" potx

... pre-germinal center subsets of B cells in PBcombined with a reduction in switched memory B cells both in PB and in BM. We showed that the reduction of switched memory B cells (CD27+IgD-) ... ascompared with rituximab-naïve. The absolute numbers of B cells in the rituximab-treated and rituximab-naïve patients areshown in Table 6. The accumulation of immature subset of B cells in BM of rituximab-treated ... followed by a long-term reduction in switched mem-ory B cells both in PB and in BM. The reduction of switched memory B cells does not prevent repopulation with autoanti-body producing B cell...

... and noresponse to a course of broad-spectrum antibiotics, and decision by a physician to treat with a full course of antitu-berculosis chemotherapy. EPTB refers to TB of organsother than the ... clinical stages, oral thrush, diar-rhoea, body mass index (BMI), anaemia and totallymphocyte count (TLC) in predicting mortality in both the pre-HAART and the HAART groups. Anaemia, history of ... history of prolonged fever, history of easy fatigability, history of tuberculosis, and the WHO clinical stage were alsoassessed as possible predictors of tuberculosis.We used the cut-off value of...

... smoking of any intensity has been implicated in muscle wasting [10] byimpairing the process of muscle protein synthesis [46]. In con-trast, in the present study, only very heavy smoking appearedto ... is, involuntaryloss of fat-free mass [FFM] with a proportional increase of body fat [BF]) in the presence of stable body weight [3,4].Body composition changes, particularly BF increase, mayremain ... further muscle loss in RA patients. A longitudinalstudy of the impact of smoking intensity (and cessation) on the body composition of patients with RA may throw more light on the mechanistic basis...

... eakness by p oin ting to the lack of defining what doubling of the risk is based on, i.e.what is the reference for doubling. When no level of risk is defined to serve as basis for doubling, the ... synergetic inter-actions, e.g. enabling attribution of the interaction effects of smoking and asbestos in the development of lung can-cers. Also, whenever the contribution by asbestos to the total ... diseases. However, since the number of reported cases is increasing, and since there is a delay in the handling of such cases by NIS, the real proportion of compensated cases may be a little higher.A...

... using bovine serum albumin as the standard [24]. Levels of lipid peroxidation were measured by the thiobarbituric acid (TBA) reaction according to the method of Ohkawa where the reaction of ... reductase [27]. The oxidation of NADPH had been observed spectrophotometrically at 340 nm, at 37ºC for 5 min. The GSH-Px activity was the slope of the line obtained by plotting the amount of NADPH ... morbid-ity and mortality. This study was designed to define the efficacy of OT as an adjuvant to antibiotherapy in an experimental rat model of sepsis. In terms of their similar mode of action,...

... receiving combination therapy.< /b> Hepatology 2004;40:1450-8. 15. Crippin JS, McCashland T, Terrault N, Sheiner P, Charlton MR. A pilot study of the tolerability and efficacy of antiviral therapy < /b> in ... costly and has not been studied rigorously in a randomized controlled format to assess their value and impact on efficacy of therapy < /b> although they are now widely used in patients receiving interferon ... against Cirrhosis), is a multicenter study of the potential benefit of prolonged peginterferon therapy < /b> in mitigating the progression of fibrotic liver disease. [8] In this study, 391 of the...