Báo cáo y học: "Downregulation of heat shock protein 70 protects rheumatoid arthritis fibroblast-like synoviocytes from nitric oxide-induced apoptosis" pot

... round of trans- Figure 2 Effect of heat shock protein 70 (Hsp70) knock-down on nitric oxide-induced apoptosis in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs)Effect of heat shock protein ... (Hsp70) in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs)Expression and specific knock-down of heat shock protein 70 (Hsp70...

Ngày tải lên: 09/08/2014, 14:22

... CW, Gay RE, et al.: Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts. ... pathways and identify susceptibility genes or susceptibility effects that might be epistatic, additive or independent. Similarly, the psoriasis study analyzed a region prev...

Ngày tải lên: 09/08/2014, 01:23

... Gay RE, Gay S: Fibroblast biology: role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res 2000, 2:361-367. 5. Firestein GS: Invasive fibroblast-like synoviocytes ... expressed by macrophage-like cells and fibroblast-like synovial cells in the lining layer and partly by endothe- lial cells in the rheumatoid arthritis (RA) synovium. The prima...

Ngày tải lên: 09/08/2014, 06:23

... the first discovery of their activation by heat shock. As a result of the universality and robustness of their response to heat shock, the stress-dependent activation of heat shock factor became ... are necessary for the establishment of chromatin structure and, likely, genome stability. Finally, in contrast to the heat shock gene paradigm, heat shock elements bound...

Ngày tải lên: 18/02/2014, 04:20

... improves symptoms and reduces mortality by 36% in patients with ischemic and non-ischemic cardiomyo- pathy in NYHA class III-IV. This is documented for stable patients on optimal medical therapy with ... clinical improvement effected by CRT in patients on IABP sup- port [9]. The rapid onset of hemodynamic improvement of CRT may be of clinical benefit in an acute setting and it is likely...

Ngày tải lên: 10/08/2014, 09:22

... fed a soy pro- tein peptic hydrolysate with bound phospholipids, compared to soy protein diet alone or soy protein hy- drolysate [76]. Part of the antiobesity effect of soy protein may be due ... of soy protein Soybeans provide one of the most abundant plant sources of dietary protein. The protein content of soybeans varies from 36% to 56% [24-27]. Protein c...

Ngày tải lên: 31/10/2012, 14:59

... Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J. Biol. Chem. 246, 4866–4871. 19. Roustan, C., Benyamin, Y. , Boyer, M., Bertrand, ... Roustan, C. & Benyamin, Y. (1993) Effects of different enzymic treatments on the release of titin fragments from rabbit skeletal myofibrils. Purification of an 80...

Ngày tải lên: 22/02/2014, 07:20

... °C. Enzyme assays Methods for the measurements of the activity of AMPK after precipitation with 6% (w/v) polyethylene glycol 6000, of ACC and p70S6K, and for immunoprecipitation of p70S6K from ... phosphorylation state of p70S6K in hepatocytes was evaluated by gel mobility shift assay [4] as well as by immunoblots with antiphosphopeptides. In vitro trials of p70S6K phosphorylati...

Ngày tải lên: 22/02/2014, 07:20

... SAPK systems. REGULATION OF SAPK SIGNAL PATHWAYS BY PROTEIN PHOSPHATASES IN YEAST CELLS A molecular g enetic analysis of ye ast cells indicated that two distinct protein phosphatase groups, protein ... activation of SAPKs requires phosphorylation of conserved tyrosine and threonine residues within the catalytic domain. This phosphorylation is mediated by dual specificity protein...

Ngày tải lên: 17/03/2014, 23:20

... formation of disulfide bonds, glycosylation, and proteolytic cleavage. The proteo- lytic cleavage of the precursor protein is achieved by digestion by a proprotein convertase, homologous to yeast subtilisin/kexin ... the proteolytic cleavage of the newly synthesized ZPC and the secretion of ZPC from the granu- losa cells. Western blot analysis of the cell lysates demon- strated t...

Ngày tải lên: 24/03/2014, 03:21