Báo cáo y học: " Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis" pps

... antibody condition). Neutralizing antibodies to MHC Figure 1 Reduced < /b> percentages of CD5 + B lymphocytes in severe arthritisReduced percentages of CD5 + B lymphocytes in severe arthritis. Type ... Lundy SK: Killer B lymphocytes: the evidence and the potential. Inflamm Res 2009 in press. 23. Lundy SK, Boros DL: Fas < /b> ligand-expressing < /b> B- 1a lymphocytes...

Ngày tải lên: 09/08/2014, 14:22

... Urokinase- mediated fibrinolysis in the synovial fluid of rheumatoid arthritis patients may be affected by the inactivation of single chain urokinase type plasminogen activator by thrombin. Ann Rheum ... of lymphocytes, uPA was injected into SCID mice lacking functional T lymphocytes and B lymphocytes. Inactivation of uPA with synthetic inhibitor Synthetic peptide H- D-Pro-Phe-Arg-ch...

Ngày tải lên: 09/08/2014, 01:21

... induced by injecting 0.3 ml of 5.0 mg/ml CFA (consisting of heat-killed Mycobacterium butyricum in Introduction We are now in an era of molecular medicine in which increasing focus is being placed ... L, Stein C: Interleukin 1 ββ and corticotropin- releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue. Proc Natl Acad Sci USA 1994, 91:4219-4223. 8. Lu...

Ngày tải lên: 09/08/2014, 01:23

... Melino G, Lee SC, Steinert PM: Protein unfolding by peptidylarginine deiminase. Substrate specificity and structural relationships of the natural sub- strates trichohyalin and filaggrin. J Biol ... probably also anti-Sa antibodies (for references see [3]). These autoantibodies all recognize epitopes contain- ing citrulline (the naming of the antibody is simply deter- mined by the substrate .....

Ngày tải lên: 09/08/2014, 01:23

... were kindly provided by Dr P Lane (Birmingham, UK) and have been previously described [30]. Antihuman CD3 and CD19 microbeads for magnetic cell sorting (MACS) were obtained from Miltenyi Biotec ... or BSA = bovine serum albumin; DC = dendritic cell; ELISA = enzyme-linked immunosorbent assay; GM-CSF = granulocyte/macrophage-colony-stim- ulating factor; IFN = interferon; IL = interleukin; ... w...

Ngày tải lên: 09/08/2014, 06:22

... peripheral blood lympho- cytes enhance the production of IL-6 and IL-8 by fibroblast-like synoviocytes, an effect that was blocked by antibodies against IL-17 [20]. Furthermore, IL-15 produced by synoviocytes ... and induces proteoglycan breakdown (Table 2) [44–47]. Furthermore, studies in vitro showed the induction of metalloproteinases by IL-17 in synoviocytes and chondrocytes [48–50]....

Ngày tải lên: 09/08/2014, 06:22

... twice and incubated for 30 min with the indicated PE- or biotin-conjugated antibodies. For the biotin-conju- gated antibodies, a third staining step with streptavidin conjugated with peridinin chlorophyll ... activity was presented by plotting the percentage of inhibition against the number of T reg cells. As shown in Fig. 4a,c, the patterns of inhibition in naive IFN-gR KO and wild-type...

Ngày tải lên: 09/08/2014, 06:22

... antibodies were mostly of IgG and not of IgE type, despite clinical symptoms indicating type I allergic reactions. The clinical relevance of measuring these antibodies is currently being investigated. In ... factor-α, has been shown to be effective in treating a variety of inflammatory diseases. In combination with methotrexate, infliximab provides significant and sustained improvement...

Ngày tải lên: 09/08/2014, 08:22

... A α 1 -Antitrypsin PEDF Fibronectin Tetranectin Fibronectin Clustrin H 4 inhibitor α 1 -Antichymotrypsin Pregnancy zone protein Gelsolin α 1 -Acid glycoprotein Fibrinogen S100 Kinninogen Albumin SHAP ... factor binding protein, acid labile subunit 4504781 Inter-alpha (globulin) inhibitor H1 4504783 Inter-alpha (globulin) inhibitor H2 31542984 Inter-alpha (globulin) inhibitor H4 (plasma Kall...

Ngày tải lên: 09/08/2014, 10:20

... significantly lower in the group with high disease activity in both the DXR-BMD and the DXA-BMD (Table 2). Table 2 Comparison of the baseline and the change in hand bone mineral density Disease ... Rosholm A, Hyldstrup L, Backsgaard L, Grunkin M, Thodberg HH: Estimation of bone mineral density by digital X-ray radiogram- metry: theoretical background and clinical testing. Osteoporos Int...

Ngày tải lên: 09/08/2014, 10:20