Báo cáo y học: " Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc" pot
Báo cáo y học: " Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc" pot
... differences in the cata-bolic pathways between painful and pain-free IVDdegeneration. While this study focused on gene and protein expression profiling, it emphasises the importance of MMP-10 in symptomatic ... to examine the gene and pro-tein expression of MMP-10 in histologically normal human IVD and compare it with that of both non -painful and painful degen-erate IVD. Gene expression of MMP-10 was ... exam-ined and was evident in NP cells and NP cell clusters (Figure2). Expression was predominantly localised intracellularlywithin the cytoplasm of the NP cells. In PM degenerate and surgical degenerate...
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Báo cáo y học: "Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage" docx
... San Leandro, CA, USA), and the inten-sity of the L-PGDS bands was normalized by dividing them by the intensity of the β-actin band of the corresponding sample.11β-PGF2α and PGD2 assays The ... (IL-1β)-induced upregulation of lipocalin-type prostaglandin D synthase (L-PGDS) expressionEffect of prostaglandin D2 (PGD2) on interleukin-1-beta (IL-1β)-induced upregulation of lipocalin-type ... factor- alphainversely regulates prostaglandin D2 and prostaglandin E2 pro-duction in murine macrophages. Synergistic action of cyclicAMP on cyclooxygenase-2 expression and prostaglandin...
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Báo cáo y học: "Increased expression of FcγRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus" ppsx
... equally to this work. YL carried outdata analysis and interpretation, and the study design, and assisted in manuscript preparation. PYL participated in dateanalysis and interpretation, and assisted ... infiltration of these cells to the sites of IC deposition in the kidney [48]. Since IFNα and IFNγ alsostimulate the production of monocyte attractants such asMCP-1, the presence of these cytokines in the ... monocytes by IgG-containing immunecomplexes is a key step in immune-complex-mediated nephritis in systemic lupus erythematosus (SLE). The goal of this studywas to determine whether expression of...
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Báo cáo y học: "Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritis" pps
... contributionsUS and NS performed the Affymetrix chip analysis. US, NS and CP analysed the MMP, cathepsin and cytokine expres-sion by real-time PCR. MH performed the zymography, the MMP activity assay and the ... recently reviewed by Yan and Sloane [34].However, the expression and function of most of the cathepsins in RA are unknown. Our results support the hypothesis that cathepsins participate in matrix- degradingprocesses. ... activity assay and zymography. By a combination of oligonucleotide chips, real-time PCR and zymography, we showed differential expressions of several MMPs, cathepsins and proteinase inhibitors in the course...
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Báo cáo y học: "Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage" ppt
... San Leandro, CA, USA), and the inten-sity of the L-PGDS bands was normalized by dividing them by the intensity of the β-actin band of the corresponding sample.11β-PGF2α and PGD2 assays The ... indicate increased expression and activity of L-PGDS in OA tissues.Figure 2 Expression of lipocalin-type prostaglandin D synthase (L-PGDS) protein in healthy and osteoarthritis (OA) cartilageExpression ... L-PGDS protein expression. Thesefindings support the hypothesis that the JNK and p3 8 MAPKsas well as the NF-κB pathways are involved in the upregulation of L-PGDS expression by IL-1β. Our results...
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Báo cáo y học: "Increased expression of FcγRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus" pdf
... equally to this work. YL carried outdata analysis and interpretation, and the study design, and assisted in manuscript preparation. PYL participated in dateanalysis and interpretation, and assisted ... infiltration of these cells to the sites of IC deposition in the kidney [48]. Since IFNα and IFNγ alsostimulate the production of monocyte attractants such asMCP-1, the presence of these cytokines in the ... by determining the migratory capacity and the ability to produce CCL2 (monocyte chemotracticprotein 1). High-sensitivity C-reactive protein, C3 and C4 weremeasured by nephelometry.Results There...
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Báo cáo y học: "Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia" potx
... fam-ily of proteolytic enzymes containing a metal in theirorganic structure playing key roles in degradation of pro-teins in extracellular matrix and in tissue remodelingthrough complicated ... family of proteolytic enzymes, known as metzincin super-family.Their catalytic action is the degradation, mainly in neutralpH environment, of all proteins of the extracellular matrix [11]. In ... In addition, they play the major role in the degradation of collagen and in the process of tissue remodeling. The present clinical study investigated blood serum levels of metalloproteinases- 1, -2, -3 and...
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Báo cáo khoa học: Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis pot
... and apoptosis,supporting the hypothesis that c-Fos and c-Jun actcoordinately to increase the expression of BimEL. Increased c-Fos levels are therefore critical for BimEL expression and apoptosis ... as PTP1B [11], MKP3 [12], and LMW-PTP [13]. The cysteines in the active sites of these phosphatasesare easily inactivated by ROS, resulting in activation of the ERK pathway [14]. However, factors ... mercaptosuccinic acid was largely attenuatedby mutating the AP-1-binding site in the bim promoterregion. Whereas the amounts of total and phosphory-lated c-Fos increased in the presence of ATZ...
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Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt
... 200220 lL of the enzyme/inhibitor mixture to 180 lLofsubstrate (4NPGlc), incubating for 30 min at 37 °C, and measuring the rel ease of 4NP.Protein assays and protein sequencingTotal protein in crude ... liver. Furthermore, we investigated the speci®city of the human CBG with r espect to the glycone and aglycone moieties, and in particular characterized the ef®ciency of the enzyme in hydrolysing a ... monomeric protein with a pI of 4.7, a broad and near-neutral pH optimum, and a broadspeci®city w ith respect to the g lycone moiety of substrates.Human CBG hydrolyses synthetic aryl glycosides (including4-nitrophenyl...
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Báo cáo Y học: Balanced expression of single subunits in a multisubunit protein, achieved by cell fusion of individual transfectants docx
... removedcompletely. The pellet was broken by gently tapping on the bottom of the tube and placed in a 37 °C water-bath.Prewarmed 0.5 mL of 50% poly(ethylene glycol) 1500(Boehringer Mannheim, Germany) was ... and hence predefined molar ratios. The result presented hereshow that the fusion event typically does not alter the expression level of the recombinant protein (Fig. 2B).Furthermore, in the study of ... the majorimmunoglobulin of external secretions and is composed of four different polypeptide chains produced by two distinctcells. Polymeric IgA (pIgA) is produced by B-cells afterassembly...
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