Báo cáo y học: " Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ" pot

... TNF-α in the induction of GCP-2, RANKL and IL-6 and inhibition by IFN-γSynergy of IL-17 and TNF-α in the induction of GCP-2, RANKL and IL-6 and inhibition by IFN-γ. (a to d) Mouse embryo fibroblasts ... whether IL-17 may directly be involved in the induc- tion of myelopoietic cytokines and/ or chemokines and whether IFN-γ may influence this process. Materi...

Ngày tải lên: 09/08/2014, 14:22

... domains or by specific phosphopeptides that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the ... diagnosis of cancer. In summary, the Gab1 A/A was associated with the low risk of H. pylori infection while the G/A and A/A genotypes together may increase the risk...

Ngày tải lên: 31/10/2012, 15:37

... the presence of increasing concentrations of Ca 2+ calmodulin, the inhibition dropped by  50% in each case. In addition, these peptides also inhibit the activity of calcineurin, another enzyme that ... with Ca 2+ calmodulin, they should also inhibit the activity of calcineurin. The four model peptides lesueurin, citropin 1.1, frenatin 3 and caerin 1. 9, all inhibit...

Ngày tải lên: 31/03/2014, 15:20

... autoimmune exocrinopathy of unknown origin. Therefore the diagnosis of SjS, in the absence of a gold standard, is based on cri- teria containing a number of subjective and objective signs and symptoms. In the ... measured by ELISA (Table 1). The presence of anti-fodrin antibodies in four sera of patients with secondary SjS was confirmed by immunoblotting (f...

Ngày tải lên: 09/08/2014, 01:23

... application may be impossible in certain areas of the joint because of anatomic factors, and the fixation of the periosteal flap or collagen sheets covering the chondrocyte suspension may Commentary A ... Despite these advances, most surgical inter- ventions only result in improvement in clinical symptoms, such as pain relief, and the regeneration of long-lasting h...

Ngày tải lên: 09/08/2014, 10:21

... autonomous of inflammation [5]. At the dawn of the era of biological therapy in RA, this theory led to the concept of a dual-therapeutic strategy, including anti-inflammatory biological therapy, on ... understanding of pathogenic mechanisms in RA, namely the link between inflammation and damage. For example, traditional paradigms regarding the mecha- nisms of joi...

Ngày tải lên: 09/08/2014, 13:22

... participated in the design of the study, analysis of DXA images, performed the statistical analysis and drafts the man- uscript. JL conceived the study and elaboration of the program used to analyse the ... HW conceived the study, participated in its design and coordina- tion, and helped to draft the manuscript. JW participated in the design of the...

Ngày tải lên: 09/08/2014, 14:22

... properly cited. and plays a key role in OS-induced inflammatory responses by mediating the expression of inflammatory genes in HUVECs [33]. Downregulation of miR-663 in tumor cells may contribute ... approximately 250 bp fragment containing the human miR-663 precursor hair- pin loops was amplified by PCR using using primers flanked by BamHIandXhoI sites at the 5’ and...

Ngày tải lên: 10/08/2014, 21:23

... scale of 0 to 3: 0, no inflammation; 1, slight thickening of synovial cell layer and/ or some inflammatory cells in the sublining; 2, thick- ening of synovial lining, infiltration of the sublining; ... strongly support the key role of inflammatory cytokines in the pathogenesis of RA [9,10] and points to therapeutic approaches directed toward regulation of cytokine...

Ngày tải lên: 09/08/2014, 07:20

... predominantly the tunica intima consisting of the endothelial layer and the basement membrane, and αSMA (e, f) staining predominantly the tunica media consisting of the muscular layer of the ... tissue of low collagen content [47]. The use of FGF-2 may therefore be of particular benefit in increasing the production of matrix in cartilage tis- sue-engine...

Ngày tải lên: 09/08/2014, 10:23