Báo cáo y học: "The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue" doc
Báo cáo y học: "The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue" doc
... article
The Ras guanine nucleotide exchange factor RasGRF1 promotes
matrix metalloproteinase-3 production in rheumatoid arthritis
synovial tissue
Joana RF Abreu*, Daphne de Launay*, Marjolein E Sanders, ... 100.
Figure 3
RasGRF1 is expressed as a truncated protein in synovial tissueRasGRF1 is expressed as a truncated protein in synovial tissue. Immu-
nobl...
Báo cáo y học: "The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis" doc
... extra-articular rheumatoid arthritis; SE,
shared epitope.
Figure 1
Variation in frequency of HLA-DRB1*0401 by disease phenotype in RAVariation in frequency of HLA-DRB1*0401 by disease phenotype in
RA. ... clustering may be
explained by both genetic and environmental factors.
The association between HLA-DRB1 genotypes and RA dis-
ease severity, including ExRA, has been interpreted...
Báo cáo y học: "The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study" docx
... anti-inflammatory
therapy, rheumatoid arthritis (RA) patients continue to rate pain
as a priority. The etiology of RA pain is likely multifactorial,
including both inflammatory and non-inflammatory components.
In ... pain sensitivity, as noted in central pain
conditions such as fibromyalgia. Future studies examining pain
sensitivity at joint and non-joint sites may identify patients w...
Báo cáo y học: "Class-switched B cells display response to therapeutic B-cell depletion in rheumatoid arthritis" docx
... preparations from RA synovitis in the early B
cell reconstitution phase after RTX. Haematoxylin-eosin
staining and immunohistochemistry for synovial B cells
during the early peripheral blood ... that synovial lymphoid structure formation
depends on trafficking of circulating rather than on locally
expanding B cells, thereby allowing B-cell monitoring after
RTX not only in the synov...
Báo cáo khoa học: Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways doc
... catalyze the intrinsic GTPase
activity of Ras proteins, thereby down-regulating Ras
signaling molecules [17± 19]. In contrast, t he Ras- guanine
nucleotide exchange factor (GEF) proteins are factors ... GRF, guanine nucleotide releasing factor; GEF,
guanine- nucleotide exchange factor; DH, Dbl homology domain;
PH, pleckstrin homology dom a in; AbLIM, acti n-binding...
Báo cáo Y học: The N-terminus of m5C-DNA methyltransferase Msp I is involved in its topoisomerase activity docx
... Changing the N-terminal residues Trp34 and
Tyr74 to alanine results in abolition of the topoisomerase I
activity while the methyltransferase activity remains intact.
Keywords: DNA binding; methyltransferase ... DNA binding and meth-
yltransferase activity, but does not possess topoisomerase
activity. These findings were substantiated using a purified
recombinant MspI protein with the N-termin...
Báo cáo Y học: The DNA-polymerase inhibiting activity of poly(b-L-malic acid) in nuclear extract during the cell cycle of Physarum polycephalum pot
... polymerases a, d,andb-like in the nuclea r e xtract, measured
in arbitrary units (staining intensity) by the highly sensitive technique o f photoaffinity labeling. Single types of DNA polymerases ... recovery of > 95% of DNA
polymerase a and > 75% of the other DNA polymerases in
the extract.
Standard DNA polymerase activity and inhibition assays
Total DNA polymerase activity was ass...
Báo cáo y học: "The abilities of improved schizophrenia patients to work and live independently in the community: a 10-year long-term outcome study from Mumbai, India" ppsx
... Meltzer HY: Outcome in schizophrenia: beyond symptom
reduction. J Clin Psychiatry 1999, 60:3-7.
54. Leucht S, Lasser R: The concepts of remission and recovery in
schizophrenia. Pharmacopsychiatry 2006, ... succeed in gainful employ-
ment. The second and more satisfying perspective is that
majority of these patients (87.7%) are living in the com-
munity within their families; 40% are e...
Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... found in
the sera of healthy individuals in that they bind to dsDNA
with high affinity, they are often cationic in charge and they
do not usually cross-react with unrelated antigens [2].
Despite intensive ... dendritic cell) staining within
the area known as germinal centre (GC) A. (b) Staining for CD20.
FDC staining suggests two possible GCs within close proximity, but
B-cell staining...
Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf
... to
interfere with the inflammatory response in SLE by adminis-
tering only an induction regime of four infusions of infliximab
within 10 weeks rather than by planning for long-term therapy.
Evidence for ... appears to play a major pro-inflammatory
role in SLE also. The available open-label experience on
infliximab therapy in SLE suggests that, in combination with
azathioprine, inflixi...