Báo cáo y học: "The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue" doc

... article The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue Joana RF Abreu*, Daphne de Launay*, Marjolein E Sanders, ... 100. Figure 3 RasGRF1 is expressed as a truncated protein in synovial tissueRasGRF1 is expressed as a truncated protein in synovial tissue. Immu- nobl...

Ngày tải lên: 09/08/2014, 14:22

... extra-articular rheumatoid arthritis; SE, shared epitope. Figure 1 Variation in frequency of HLA-DRB1*0401 by disease phenotype in RAVariation in frequency of HLA-DRB1*0401 by disease phenotype in RA. ... clustering may be explained by both genetic and environmental factors. The association between HLA-DRB1 genotypes and RA dis- ease severity, including ExRA, has been interpreted...

Ngày tải lên: 09/08/2014, 07:20

... anti-inflammatory therapy, rheumatoid arthritis (RA) patients continue to rate pain as a priority. The etiology of RA pain is likely multifactorial, including both inflammatory and non-inflammatory components. In ... pain sensitivity, as noted in central pain conditions such as fibromyalgia. Future studies examining pain sensitivity at joint and non-joint sites may identify patients w...

Ngày tải lên: 09/08/2014, 14:22

... preparations from RA synovitis in the early B cell reconstitution phase after RTX. Haematoxylin-eosin staining and immunohistochemistry for synovial B cells during the early peripheral blood ... that synovial lymphoid structure formation depends on trafficking of circulating rather than on locally expanding B cells, thereby allowing B-cell monitoring after RTX not only in the synov...

Ngày tải lên: 09/08/2014, 14:20

... catalyze the intrinsic GTPase activity of Ras proteins, thereby down-regulating Ras signaling molecules [17± 19]. In contrast, t he Ras- guanine nucleotide exchange factor (GEF) proteins are factors ... GRF, guanine nucleotide releasing factor; GEF, guanine- nucleotide exchange factor; DH, Dbl homology domain; PH, pleckstrin homology dom a in; AbLIM, acti n-binding...

Ngày tải lên: 17/03/2014, 11:20

... Changing the N-terminal residues Trp34 and Tyr74 to alanine results in abolition of the topoisomerase I activity while the methyltransferase activity remains intact. Keywords: DNA binding; methyltransferase ... DNA binding and meth- yltransferase activity, but does not possess topoisomerase activity. These findings were substantiated using a purified recombinant MspI protein with the N-termin...

Ngày tải lên: 24/03/2014, 00:21

... polymerases a, d,andb-like in the nuclea r e xtract, measured in arbitrary units (staining intensity) by the highly sensitive technique o f photoaffinity labeling. Single types of DNA polymerases ... recovery of > 95% of DNA polymerase a and > 75% of the other DNA polymerases in the extract. Standard DNA polymerase activity and inhibition assays Total DNA polymerase activity was ass...

Ngày tải lên: 31/03/2014, 21:21

... Meltzer HY: Outcome in schizophrenia: beyond symptom reduction. J Clin Psychiatry 1999, 60:3-7. 54. Leucht S, Lasser R: The concepts of remission and recovery in schizophrenia. Pharmacopsychiatry 2006, ... succeed in gainful employ- ment. The second and more satisfying perspective is that majority of these patients (87.7%) are living in the com- munity within their families; 40% are e...

Ngày tải lên: 08/08/2014, 23:21

... found in the sera of healthy individuals in that they bind to dsDNA with high affinity, they are often cationic in charge and they do not usually cross-react with unrelated antigens [2]. Despite intensive ... dendritic cell) staining within the area known as germinal centre (GC) A. (b) Staining for CD20. FDC staining suggests two possible GCs within close proximity, but B-cell staining...

Ngày tải lên: 09/08/2014, 01:21

... to interfere with the inflammatory response in SLE by adminis- tering only an induction regime of four infusions of infliximab within 10 weeks rather than by planning for long-term therapy. Evidence for ... appears to play a major pro-inflammatory role in SLE also. The available open-label experience on infliximab therapy in SLE suggests that, in combination with azathioprine, inflixi...

Ngày tải lên: 09/08/2014, 10:22