Báo cáo y học: "B cells in autoimmunity" ppsx

... [53,55] in myeloid cells suggests that BAFF may act as a kind of secondary cytokine translating mainly IFN and TNF effects. An important immunoregulatory cytokine produced by B cells is IL-10, ... number of recent findings. First, findings in both humans and mice have indicated an essential role for this cytokine in co-stimulating B cells to differentiate into plasma cells [29]....

Ngày tải lên: 09/08/2014, 14:22

... critically involved in the homing of B cells to lymphoid follicles and in the development of organized lymphoid follicles in healthy individuals [60]. Mice deficient in the lymphoid-homing chemokine ... sixth heavy-chain joining segment (J H 6) [79], emphasizing the accumulation of memory B cells. Thereby, enhanced influx and retention of particular polyclonal memory B cells into...

Ngày tải lên: 09/08/2014, 10:20

... B lymphocytes. Rheum Dis Clin North Am 2001, 27: 335-353. 24. Weyand CM, Goronzy JJ, Takemura S, Kurtin PJ: Cell-cell inter- actions in synovitis. Interactions between T cells and B cells in rheumatoid ... regimens employing cytokine blockage and that may be well suitable for a subset of patients. Identifying the mechanisms by which B cells control disease activity will be necessary...

Ngày tải lên: 09/08/2014, 01:21

... selectins and integrins on synovial endothelium, allowing migration up chemotactic gradients into the joint. The composition of inflammatory cells recruited in a continuing fashion by mast cells, including ... the synovial mesenchyme The synovial mesenchyme, consisting principally of synovial fibroblasts, is prominently involved in joint inflammation. Fibroblasts increase greatly in...

Ngày tải lên: 09/08/2014, 01:24

... CD19 + B cells is dependent on HLA DRB1 In the initial, retrospective study, the frequency of B cells was determined as a percentage of CD19 + lymphocytes from total T lymphocytes and B lymphocytes ... and recirculate into the peripheral circulation [20,21]. In the present study, the accessible B lymphocytes in the peripheral circulation were analyzed by flow cytometry to determine...

Ngày tải lên: 09/08/2014, 03:24

... staining for cytokeratin 7 (a) and cytokeratin 19 (b) and the absence of staining with cytokeratin 20 (c) indicates the specificity of ductal epithelial cell origin. The absence of staining ... BAFF induction by cytokines is cell and disease depend- ent. IL-10, a cytokine involved in BAFF stimulation in mono- cytes and myeloid dendritic cells [47], did not influence BAFF expression i...

Ngày tải lên: 09/08/2014, 07:20

... protects the cells from TNFa-induced U937 cell apoptosis by maintaining mitochondrial integrity and function [43], and ricin-induced apoptosis of U937 cells by maintaining an intracellular reducing condition ... Biochemistry, Faculty of Pharmacy, Tokyo University of Pharmacy & Life Science, Tokyo, Japan; 2 Yoneyama Maternity Hospital, Tokyo, Japan Previously, we demonstrated apoptotic...

Ngày tải lên: 22/02/2014, 07:20

... to quantify urinary BLyS levels. Once an assay for urinary BLyS levels is validated, we should be able to assess the effect of urinary BLyS excretion on circulating BLyS levels. Third, BLyS promotes in ... into (pathogenic) autoantibody secreting plasma cells. In contrast to murine studies, in which investigators can readily harvest and analyze lymphoid and myeloid lineage cells from...

Ngày tải lên: 09/08/2014, 07:20

... profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines inter- leukin-1 beta and tumour necrosis factor. Inflamm Res 2005, 54:10-16. 42. Zhou A, Scoggin S, Gaynor ... Membrane-type 1 matrix metalloprotein cytoplasmic tail binding protein 1 MTCBP-1 2p25.2 -2.04 0.005 148134 RP1-29K1 containing KiAA0426 NS0.002 127203 CytP450, family 4, subfamily F, polyp...

Ngày tải lên: 09/08/2014, 08:22

... Black bars, day 14 (proliferation); grey bars, day 28 (nonmineralizing hypertro- phy); white bars, day 35 (mineralizing hypertrophy). Note increase of expression in ank under mineralizing conditions, ... of the P5L cell line with levamisole inhibited AP activity, and resulted in an increase in ePPi in the P5L cells, suggesting that excess ePPi is being hydrolyzed by AP during the m...

Ngày tải lên: 09/08/2014, 08:23