Báo cáo y học: "Tumor necrosis factor α-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis" pptx

... analysis using splenocytes of mice with GPI-induced arthritis. Expression of TNFα-induced adipose-related protein (TIARP) mRNA and protein in spleens, joints and lymph nodes was evaluated, and fluctuation ... splenocytes. In arthritic mice, TIARP mRNA was expressed mainly in CD11b + cells in the spleen, and TIARP mRNA level was increased in the joints (accompanied...

Ngày tải lên: 09/08/2014, 14:22

... the DNA -protein binding activity induced by HBO. Exogenous addition of TNF-a significantly increased the DNA -protein binding activity. To study whether the visfatin expression induced by HBO is ... Secondly, TNF-a actsasanautocrinefactorto mediate HBO-induced visfatinproteinexpressionin human CAECs. Thirdly, JNK kinase and AP-1 transcrip- tion factor are involved in the signaling...

Ngày tải lên: 10/08/2014, 05:21

... = interleukin; MAPK = mitogen-activated protein kinase; MEK1/2 = mitogen-activated protein kinase kinase 1 and 2; NF = nuclear factor; PARP = poly(ADP ribose) polymerase; PKC = protein kinase ... involved in regulating the aggrecan and type II collagen genes and in remodeling of the cytoskeleton in response to factors present during inflammation. The MAPK/ERK pathway plays...

Ngày tải lên: 09/08/2014, 06:22

... initially treated in a randomized placebo-controlled trial [2] and afterwards Commentary Tumor necrosis factor- αα blockade in ankylosing spondylitis: a potent but expensive anti-inflammatory ... et al., http:/ /arthritis- research.com/content/7/3/R439 123 decrease in the hypervascularity typical of SpA and a reduction of the synovial lining hyperplasia, indicating that inflixim...

Ngày tải lên: 09/08/2014, 06:23

... signaling via NADPH oxidase activation. CD36 expression on human monocytes is inhibited by TNFα and independently increased by adalimumab. These data highlight that pro-inflammatory cytokines and ... observed in rheumatoid arthritis. Introduction In chronic inflammatory diseases, such as rheumatoid arthritis (RA), systemic inflammation appears as an independent risk factor,...

Ngày tải lên: 09/08/2014, 10:20

... Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. ... Coordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis. An immunohistochemical study. Am J Pathol 1993, 142:95-105. 3...

Ngày tải lên: 09/08/2014, 14:22

... the production of the active cytokines interleukin-1b, interleukin-18 and interleukin-33 [6–9]. Involvement of caspase-1 in TNF-a-induced cytotoxicity has been determined by employing inhibitors of caspase-1 [10–12]. ... genes, including interferon regula- tory factor- 1 (IRF-1) [4,5]. Caspase-1 is a cysteine protease that catalyses the proteolytic processing of the pro -in ammatory cyto...

Ngày tải lên: 16/03/2014, 05:20

... ADAM (a disintegrin and metalloproteinase) family of type I membrane proteins and mediates the ectodomain shedding of various membrane- anchored signaling and adhesion proteins. TACE is syn- thesized ... characterized by a well defined domain structure, consisting of a N-terminal prodomain followed by a metalloproteinase domain, a disintegrin domain, a cysteine rich domain, which usually...

Ngày tải lên: 08/03/2014, 02:20

... subtypes, and to oligodendrocytes, microglia and astrocytes in the brain, to endothelial cells, and certain T-cell subpopulations, including lymphocytes (CD4 + and CD8 + T cells), cardiac myocytes, ... reduced IjBa phosphorylation[56], thus indicating that the phosphatidylinositol 3-kinase- protein kinase B ⁄ serine-threonine kinase pathway may play a major role in TNFR2-mediate...

Ngày tải lên: 28/03/2014, 23:20

... of brain injury are mediated in large part by a profound host-mediated intracranial inflammatory response [3-5]. The pro-inflammatory cytokines tumor necrosis factor (TNF) and interleukin (IL)-18 ... TNF by LT-α which binds to Table 1: Clinical data and intrathecal cytokine levels in patients with severe closed head injury. Patient Age (years) / Gender Type of brain injury (Mars...

Ngày tải lên: 19/06/2014, 22:20