Báo cáo y học: "Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort" pdf

... Markers of B-cell activation are elevated in patients with early RA, compared with undifferentiated arthritis, independently of any systemic increase in BAFF secretion, and correlate with disease activity. ... B-cell activation [32]. Investigation of the role of APRIL in the B-cell activation of patients with early RA therefore appears usef...

Ngày tải lên: 09/08/2014, 14:22

... that combinations of polymorphic genes may act in concert in the pathogenesis of SLE, a concept that may be instrumental in the analysis of the genetics of SLE as well as providing hypotheses for ... common. Ninety percent of the SLE patients with HLA DR3 displayed the haplotype DR3-DQ2- C4AQ0, compared with 86% of the controls. The frequen- cies of th...

Ngày tải lên: 09/08/2014, 01:24

... findings as preliminary and requiring replication in other settings. Additionally, data from the VA might be gathered differently from other health care systems, again highlighting the preliminary ... antibody therapy in rheumatoid arthritis and Figure 1 This plot illustrates the median and interquartile range for the tertiles of the claims-based index of rheumato...

Ngày tải lên: 09/08/2014, 10:23

... Duration of VIT < 5 years • Repeated re-stings after stopping VIT Patients with reactions during immunotherapy are encouraged to receive immunotherapy indefinitely. In our survey 229 patients ... studies are needed to evaluate the accuracy of the test. Competing interests The authors declare that they have no competing interests. Authors' contributions MK has bee...

Ngày tải lên: 08/08/2014, 21:20

... combined antiretroviral therapy (cART) with or without ABC were compared in order to pinpoint a pathogenic mechanism for the increased risk of myocardial infarction in patients using ABC. Given the important role of ... increased incidence of myocardial infarction. The pathophysiological mechanism is unknown. In this study markers of inflammation and coagulation in...

Ngày tải lên: 10/08/2014, 05:21

... present in inclusion body. In order to recover its function, the fusion protein in inclusion body was refolded in urea gradient refolding buffer. And then, the refolded protein was incubated with ... used a glycine-rich short peptide including 15 amino acids to connect the N-terminus of globular adiponectin and the C-terminus of GLP-1-A. Compared with native G...

Ngày tải lên: 25/10/2012, 11:10

... fat as the tumour invades it. Thus, carcinoma is typically characterized by the lack of isolated pockets of fat within its mass and this is demonstrated in these results by the lack of any adipose ... fibroglandular and fibrocystic changes peaks are close, they are statistically separated. Using the results in Table 2 effective d-spacings have been found. These...

Ngày tải lên: 02/11/2012, 11:08

... HCD apparently potentiated the cytokine-inducing effects of LPS without qualitatively altering their sequence of appearance. Others found that hypercholesterolemia increased the induction of plasma ... 9). VCAM-1 and iNOS were measured since they are part of an inflammatory cascade induced by LPS. VCAM-1 medi- ates localization of various inflammatory cells in tissues. iNO...

Ngày tải lên: 11/08/2014, 08:21

... gelatin substrate at sites of net gelatinase activity yields fluorescent gelatin- FITC peptides and the intensity is proportional to the amount of activity within in the tissue. Corneal epithelial ... and the intensity of the stain- ing was analyzed in digital images (Figure 2A). Using dual label laser scanning immunofluorescent microscopy, both IL-2R chains were p...

Ngày tải lên: 11/08/2014, 08:22

... on the secondary structures indicate the length of the single stranded regions. Black rectangles locate Hfq binding sites determined by enzymatic and chemical probing and by mutational analysis. ... hierarchy of Hfq binding efficiency to these different RNAs harboring internal or 3¢ terminal presumptive binding sites. Interestingly, Fig. 3 shows that Hfq exhibits roughly the sa...

Ngày tải lên: 19/02/2014, 16:20