Báo cáo y học: "Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to biologic therapies" ppt

... com- bined with other key pro-inflammatory cytokines it significantly potentiated the effect of TNF-α and OSM on MMP-1 and MMP-13 production. This had a profound effect on the MMP/ TIMP ratios, ... examine the expression of IL-17A in actively inflamed joints and to elucidate the mecha- nism of IL-17A, alone and in combination with TNF-α and oncostatin M (OSM) in...

Ngày tải lên: 09/08/2014, 14:22

... concepts of rheumatoid arthritis. Nature 2003, 423:356-361. 35. Morita Y, Yamamura M, Kawashima M, Harada S, Tsuji K, Shibuya K, Maruyama K, Makino H: Flow cytometric single-cell analysis of cytokine ... Buckley 1,2 and Mike Salmon 1 1 MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK 2 Department of Rheumat...

Ngày tải lên: 09/08/2014, 06:22

... It is a key building block of membrane bilayers, com- prising a high proportion of the outer leaflet of the plasma membrane. To identify plant START domains that are most similar to mammalian PCTP, ... addition to an amino-terminal SAM domain is apparent only in proteins from humans, mouse, and rat, indicating that SAM-RhoGAP- START proteins are specific to mammals. Similarly,...

Ngày tải lên: 09/08/2014, 20:20

... deficiency of complement may lead to ineffec- tive opsonization, lytic activity or impairment of B-cell memory, by which reduce tissue i njury [15]. Unfortu- nately, the mechanisms by which C4 abnormality ... C4A protect from autoimmune disease? Immunol Today 1997, 18(4):199. 19. Seelen MA, Daha MR: The role of complement in autoimmune renal disease. Autoimmunity 2006, 39(5):411-415...

Ngày tải lên: 10/08/2014, 10:20

... abduction 4. to modify a Hoffer transfer [2], using the latissimus dorsi muscle (ldm) to improve the lateral shoulder rotation with an abducted arm, and tmm to allow an active abduction up to 90° (horizontal ... subcutaneous tissue is divided, and the lateral borders of both ldm and tmm are identified and dissected free. The tmm is dissected free from the ldm pro- gressi...

Ngày tải lên: 10/08/2014, 10:20

... Chakravarty EF, Sanchez-Yamamoto D, Bush TM: The use of disease modifying antirheumatic drugs in women with rheumatoid arthritis of childbearing age: a survey of practice pattern and pregnancy outcomes. ... Ostensen M, Ramseyu-Goldman R: Treatment of inflammatory rheumatic disorders in pregnancy. Drug Safety 1998,19:389- 410. 62. Parke AL: Antimalarial drugs, systemic lupus e...

Ngày tải lên: 09/08/2014, 08:22

... College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis. The Com- mittee on Outcome Measures in Rheumatoid Arthritis Clinical Trials. Arthritis Rheum 1993, ... understanding of rheumatoid arthritis Josef S Smolen and Daniel Aletaha Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna,...

Ngày tải lên: 09/08/2014, 01:22

... due to a soluble factor(s)-mediated interaction with monocytes. Our immunohistochemistry results demonstrate that local administration of glucocorticoids decreases the number of lymphocytes without ... intra- articular injection of 40 mg of triamcinolone hexacetonide. Synovial biopsy samples from areas close to cartilage were obtained prior to and a median of 11 days (ra...

Ngày tải lên: 09/08/2014, 01:22

... fragment of type II collagen in rheumatoid arthritis Andrew D Cook 1 , Robyn Gray 1 , John Ramshaw 2 , Ian R Mackay 1 and Merrill J Rowley 1 1 Department of Biochemistry and Molecular Biology, Monash ... colla- gens (types II, IX, and XI) and to type I collagen in rheumatoid arthritis. Ann Rheum Dis 1987, 46:902-907. 6. Terato K, Shimozuru Y, Katayama K, Takemitsu Y, Y...

Ngày tải lên: 09/08/2014, 01:23

... Zaleska M, Cooke CJ, Miller NE: Lymph draining from foot joints in rheumatoid arthritis provides insight into local cytokine and chemokine production and transport to lymph nodes. Arthritis Rheum 2001, ... synovium can transform into an invasive tissue (pannus) that destroys cartilage and bone. Synovectomy of a joint, performed surgically, chemically or by radiation the...

Ngày tải lên: 09/08/2014, 01:24