Báo cáo y học: "Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus" doc

... characterized the role of the IFNAR2 chain of the type I IFN (IFN -I) receptor in the targeting of nucleic acid-associated autoantigens and in B-cell expression of the nucleic acid-sensing Toll-like receptors (TLRs), ... pro- file and TLR-dependent B-cell response in SLE mice geneti- cally deficient in the IFNAR2 chain of the IFNAR. Autoantibody pro...

Ngày tải lên: 09/08/2014, 14:22

... by DNA breaks. The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD + ) and adenosine triphosphate (ATP) contributes to significant cytotoxicity in inflammation ... USA. 3 Departments of Critical Care Medicine and Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. 4 Division of Critical Care Medicine, C...

Ngày tải lên: 11/08/2014, 03:20

... USA. 4 Division of Critical Care Medicine, Cincinnati Children’s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA. Authors’ contributions HS ... DNA sites [5]. Thus, it is possible that both physical interaction with PARP-1 and poly (ADP-ribosylation) of HSF-1 reduce the availability of HSF-1 to initiate transcription. The...

Ngày tải lên: 11/08/2014, 06:22

... to cartilage better in CIX-deficient mice than in wild type animals. This finding demonstrates that a lack of CIX in cartilage leads to an increased accessibility of structures for antibody binding and ... cited. Abstract Joint cartilage is attacked in both autoimmune inflammatory and osteoarthritic processes. Type IX collagen (CIX) is a protein of importance for cartila...

Ngày tải lên: 09/08/2014, 08:22

... Blockade of TLR3 signaling was achieved using TLR3 neutralizing antibody, small interference RNA, and 2-aminopurine (2-AP), an inhibitor of protein kinase R (PKR), an interferon- induced, double-stranded ... cultured with DMEM containing 10% (v/v) heat-inactivated fetal bovine serum (FBS;Invitrogen,Carlsbad,CA),L-glutamine,non- essential amino acids (Invitrogen; 10 mM) and antibio- t...

Ngày tải lên: 10/08/2014, 10:20

... found among the minor local structural and chemical differences in the vicinity of the mutation. The substitutions of a charged and linear lysine for a uncharged and branched asparagine at position ... H activity as well as initiation of polymerization may be affected by these NNRTI-induced distortions [2,3]. Despite the in itial efficacy in combating HIV infection, NNRTI...

Ngày tải lên: 18/03/2014, 01:20

... coli-derived BMP-6 is also inactive, due to its inability to bind ActR -I; the green dashed line indi- cates maximal proliferation in the absence of any BMP ligand. Type I receptor specificity of ... first carbohydrate moiety at Asn73 is a main binding determinant for ActR -I interaction, whereas further carbohydrate resi- dues in the carbohydrate chain are not required. The aspa...

Ngày tải lên: 23/03/2014, 07:20

... ability of RSV to induce expression and cat- alytic activity IKKε which blocks RSV-induced IRF3 phos- phorylation, nuclear translocation and DNA-binding, and leading to inhibition of cytokine gene ... has a role in modifying ISG15. The finding in this study that G protein expression inhibits IFNβ and ISG15 protein expression is consistent with evidence suggesting that...

Ngày tải lên: 20/06/2014, 01:20

... can induce nausea, especia lly at higher doses [13], conversely reducing striatal dopaminergic neurotransmission [2]. Amisulpride i s an atypical antipsychotic possibly act- ing as a dopamine stabiliser ... antagonist, dual serotonin and norepinephrine agent (NaSSA) mirtaza- pine (for example, at 30 mg/day) [14], which may he lp in anti-obsessive and antiemetic management via 5-HT3...

Ngày tải lên: 09/08/2014, 01:21

... mRNA Kit (Qiagen Inc, Mississ- auga, ON, Canada). A skin cDNA library was constructed, as described by the manufacturer, using Lambda ZAPÒ II library and ZAP-cDNAÒ Synthesis Kit and Gigapack Ò Gold ... families. Blood plasma from Atlantic (Liparis atlanticus) and dusky (Liparis gibbus) snailfish contain type I AFPs that are significantly larger than all previously described type I A...

Ngày tải lên: 20/02/2014, 02:22