Báo cáo y học: "Predictors of major infections in systemic lupus erythematosus" pptx

... properly cited. Abstract Introduction Infections commonly complicate the course of systemic lupus erythematosus (SLE). Our aim is to investigate the clinical predictors of major infections in patients ... Working Party on Systemic Lupus Erythematosus: Morbidity and mortality in systemic lupus erythematosus during a 10- year period. A comparison of early and late ma...

Ngày tải lên: 09/08/2014, 14:22

... in human systemic lupus erythematosus. Curr Opin Immunol 2004, 16:801-807. 21. Dong J, Wang QX, Zhou CY, Ma XF, Zhang YC: Activation of the STAT1 signalling pathway in lupus nephritis in MRL/lpr ... genotyped using the TaqMan SNP Genotyping Assay (Applied Biosystems, Foster City, CA, USA), and association was examined in 308 SLE patients and 306 healthy individuals. Statistica...

Ngày tải lên: 09/08/2014, 13:22

... generated by larger GWAS, can be used to piece together the key pathways involved in lupus pathogenesis, with each pathway constructed of a number of interacting proteins making an individual ... because not only do particular individuals carry different combinations of risk alleles, but the genotyping chips do not carry every susceptibility allele for a given locus. Interpretation...

Ngày tải lên: 09/08/2014, 14:22

... with clinically and pathologically proven steatosis and 98 patients without steatosis were recruited into this study. The levels of fasting blood glucose (FBG), fasting insulin (FINS), triglyceride ... levels of serum alanine aminotransferase (ALT). The higher prevalence of hepatic steatosis in Hispanics was mainly due to the higher prevalence of obesity and insulin resistance...

Ngày tải lên: 25/10/2012, 11:48

... which may lead to pulmonary edema and to respiratory failure unless early dialysis is initiated. Pharma- cokinetics of drugs such as high cyclophosphamide metabolites are poorly understood in patients ... this reason, in patients with either renal insuffi- ciency or renal failure, dialysis is performed each morning after a cyclophosphamide infusion the preceding day. Besides tapering of...

Ngày tải lên: 09/08/2014, 01:23

... some DMARDs [14]. The findings of increased risk for developing infusion reactions in ANA-positive RA patients in our study support the plausibility of underlying immunogenetic mecha- nisms of drug-related ... allergic, namely IgE-mediated type I reactions (anaphylactic reactions), including hypotension, bronchospasm, wheezing and/or urti- caria. However, the great majority of inf...

Ngày tải lên: 09/08/2014, 08:22

... absence of detectable HBV DNA at the time of OLT and absence of reinfection for a minimum of 6 months post-OLT. After one year, reinfection occurred in 20% of patients in each group, but the finding ... finding of circulating HBV DNA by PCR in 2 of 11 receiving HBIG and 5 of 10 receiving LAM suggests that reinfection would be likely in additional patients with long...

Ngày tải lên: 02/11/2012, 11:17

... level of the has operon containing the hyaluronan synthase gene or the protein level of hyaluronan synthase. Solubilization of the enzyme from membranes of MU-treated cells and addition of the ... little involvement of MU-meta- bolites in the inhibition of HA synthesis by MU in FM100 cells. These above results indicate that something required for a fully functional HA synthe...

Ngày tải lên: 08/03/2014, 09:20

... Biology, University of Insubria, Varese, Italy Y2 38, one of the very few conserved residues in the active site of D -amino acid oxidases (DAAO), was mutated to phe- nylalanine and serine in the ... depending on the size of the ligand side chain [27]. Our results indicate that the role of Y2 23 and Y2 38 in the active site of RgDAAO is different from that of the tyrosin...

Ngày tải lên: 17/03/2014, 17:20

... His42, may be in uen- tial in defining the stability of Compound II. The replacement of the distal histidine residue by alanine or glutamic acid clearly has a profound in uence on the ability of the ... performed by global analysis and numerical integration methods using PROKIN software (Applied Photophysics). RESULTS Mass spectrometry The integrity of the variant proteins was exam...

Ngày tải lên: 18/03/2014, 01:20