Báo cáo y học: "Rheumatoid arthritis and smoking: putting the pieces together" pot

... smokers are able to phagocytose intracellular bacteria, they are unable Review Rheumatoid arthritis and smoking: putting the pieces together Zsuzsanna Baka 1 , Edit Buzás 1 and György Nagy 1,2 1 Department ... homology between certain HLA alleles associated with RA and hemolysins of P. mirabilis. They also identified another homology between type XI collagen and Proteus urea...

Ngày tải lên: 09/08/2014, 14:22

... usually reduced the complexity by removing the glycans and tagging the Ser or Thr. This yields information about the glycosylation sites, but gives no information about the glycan heterogene- ity ... core 2 glycans have the potential to be elaborated into larger glycans. Many of the core structures have the same mass, and linkage analysis is usually needed to differentiate...

Ngày tải lên: 29/03/2014, 08:20

... [8]). Besides their high specificity, they share more features with the anti-Sa antibodies. They can be detected very early in the disease and can often predict the clinical outcome of the disease ... in The Netherlands by “Het Nationaal Reumafonds” of the Netherlands (Dutch League against Rheumatism), The Netherlands Foundation for Research (NWO grant 940-35-037), and the...

Ngày tải lên: 09/08/2014, 01:23

... inflammatory cells in RA. CD11c + myeloid DCs and CD123 + pDCs were compared in normal and RA PB, synovial fluid (SF), and synovial tissue by flow cytometry, immunohistochemistry, and electron ... activation of the endothelium by TNF-α is particularly important in cel- lular recruitment to the synovium [29-31]. Since RA is char- acterized by endothelial activation, leukocyte recr...

Ngày tải lên: 09/08/2014, 06:22

... Felty's syndrome, neuropathy and scleritis. Use of corticosteroids and disease modifying therapy was fairly typi- cal of patients with long-standing RA. Coronary artery involvement There ... Kopecky SL, Frye RL, Goronzy JJ, Weyand CM: T-cell-mediated lysis of endothelial cells in acute coronary syndromes. Circulation 2002, 105:570-575. 11. Martens PB, Goronzy JJ, Schaid D, Weyand CM:...

Ngày tải lên: 09/08/2014, 06:23

... More time and efforts are needed to understand the role of the ERAD system in human RA and to define other as yet unknown aspects of RA before the design of any ERAD-based therapy for the disease. Competing ... verify the hypothesis that Synoviolin is important for the development of arthritis using Synoviolin- knockout mice; that is, a ‘loss-of-function’ study. Collagen Fig...

Ngày tải lên: 09/08/2014, 07:20

... Arthritis Research & Therapy Vol 7 No 6 Dieudé et al. R1201 systemic lupus erythematosus and with autoimmune thyroid disease [12-19]. The PTPN22 gene encodes for the intracel- lular tyrosine ... control sample of the previous study [12], observing the association between the 1858T allele and early RF + RA. The study also suggested a stronger association for the homozy...

Ngày tải lên: 09/08/2014, 07:20

... membrane and in addition to de novo synthesis, the plant enzyme is capable of catalysing the exchange of the inositol polar head for another inositol. Our data clearly show that the CDP-diacylglycerol-independent exchange ... synthase catalyses a true reverse reaction. The enzymatic activity we detected is nevertheless strictly dependent on CMP, and strictly associated with the...

Ngày tải lên: 22/02/2014, 04:20

... regions adjacent to the beginning and the end of ybdQ and additional 20-nucleotide complementary to the template plasmid pKD13 carrying the kanamycin resistance (kan) gene. The resulted linear 1.4-kb ... separated by SDS/PAGE using the standard Laemmli system [30] with 13% and 4% (w/w) acrylamide in the separating and stacking gels, respectively. In order to estimate th...

Ngày tải lên: 22/02/2014, 07:20

... versatile enzymes in nonaqueous solvent systems in which they catalyze the synthesis of a variety of acylglycerols and specialized esters via transesterification. Lipases demonstrating high activity under ... analysis [6]. LipA demonstrates hydrolytic activity toward emulsions of both medium and long chain triacylglycerols (Fig. 3). Areas of olive oil and tricaprylin hydrolysis are cle...

Ngày tải lên: 23/03/2014, 21:20