Báo cáo y học: " Myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab" pdf

... article Myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab Christophe ... Mann–Whitney U test. Figure 5 Infliximab maintains plasmacytoid dendritic cells exposed to influenza virus in an IFNα secreting stateInflixim...

Ngày tải lên: 09/08/2014, 14:22

... evident in all nine patients before and during infliximab treatment and was most prominent in the lining layer, in areas with cellular infiltrates and in certain blood vessel walls. Both an increased ... and induce production of several pro-inflammatory cytokines such as IL-6, IL-1β and TNF by macrophages and dendritic cells, thereby sustaining prolonged inflammation [16,36]....

Ngày tải lên: 09/08/2014, 10:23

... TNF in patients with RA. The present study supports the hypothesis that HMGB1 release is independent of TNF activity in patients with RA. If reproduced in larger clinical trials then, together with ... predominance within synovial tissue [7]. The injection of rHMGB1 results in mild to moderate synovitis and may persist for at least 28 days. The induction of arthritis by...

Ngày tải lên: 09/08/2014, 10:23

... biological agent in patients treated with infliximab is due mainly to a loss of response during treatment, whereas in patients treated with etanercept, switching is due to non -response. The effectiveness ... behalf of the Research in Active Rheumatoid Arthritis (ReAct) Study Group: Effectiveness of adalimumab for rheumatoid arthritis in patients with a his...

Ngày tải lên: 09/08/2014, 14:22

... proinflammatory cytokines, including angiogenic factors. These results suggest that the elevated expression of AREG in synovial tissues may be involved in RA pathology containing synovial hyperplasia. ... transduction in rheumatoid synovitis. Semin Arthritis Rheum 1992, 21:317-329. 7. Takeuchi T, Abe T: Tyrosine phosphorylated proteins in syno- vial cells of rheumatoid arthri...

Ngày tải lên: 11/08/2014, 08:21

... deficiency results in increased circulating lysosomal hydrolases, which indicates that these molecules may be nec- essary for certain aspects of glycoprotein homeostasis [11]. Surface glycoprotein ... adhesion molecule-grabbing nonintegrin expression in systemic lupus erythematosus dendritic cells. Dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin (DC-SIG...

Ngày tải lên: 09/08/2014, 13:22

... analysis a correlation matrix was initially made for all independent variables in order to determine which indicators to be included in the final model. For those variables that were in- ter-correlated ... identified in this manner are the same as those identified clinically. In a study of children between 1 – 2 years of age the pa- rental questionnaire was only able to identif...

Ngày tải lên: 26/10/2012, 09:48

... unwinding is also in uenced by phosphorylation of Thr124 of T antigen, probably catalysed by cyclin A/cdk2 [53–56]. As neither staurosporine nor olomoucine, both inhibitors of cyclin A/ cdk2, inhibit ... antigen-catalysed unwinding of the SV40 origin occurred, however, only after re-oxygenation as indicated by (a) increased sensitivity of re-oxygenated minichromosomes against digestion with...

Ngày tải lên: 22/02/2014, 04:20

... mechanism by which homocysteine exerts its effects is still not known. Patients with hyperhom- ocysteinemia have homocysteine levels in the 0.1–0.25 m M range. In these studies, homocysteine was ... toxicity was enhanced. In the presence of homocysteine, Ab1–40 caused a 40% increase in toxicity over that with homocysteine alone, while Ab1–42 caused a further 50% increase in to...

Ngày tải lên: 22/02/2014, 07:20

... dithiol dinitrosyl–Fe complexes within cells [23,30]. Further, Rogers and Ding [48] have shown that L -cysteine is necessary for the removal of dinitrosyl–Fe complexes from [Fe–S]-containing proteins in Escherichia ... levels in cells prelabelled with [ 59 Fe]transferrin. In prelabelled cells, ferritin- 59 Fe levels increased 3.5)fold when cells were reincubated with control...

Ngày tải lên: 08/03/2014, 22:20