Báo cáo y học: "Outcome measures in inflammatory rheumatic diseases" pdf

... treatment in the inflammatory rheumatic diseases nowadays has become reaching and sustaining remission. Clinical remission, meaning absence of clinically visible disease manifestations, including the ... Heijde D, Bellamy N, Calin A, Dougados M, Khan MA, van der Linden S: Assessments in Ankylosing Spondylitis Working Group. Preliminary core sets for endpoints in ankylosing spondylit...

Ngày tải lên: 09/08/2014, 14:22

... [55]. Cell sources for tissue engineering in rheumatic diseases Today, autologous chondrocytes represent the only cell type routinely used for joint cartilage repair. In the future, autolo- gous or ... purpose, 3D in vitro high-density chondrocyte pellet and alginate cultures help to preserve/regain the chondrocyte phenotype following monolayer expansion by offering cell-cell and cell...

Ngày tải lên: 09/08/2014, 01:22

... functionally modulate the course of inflammatory arthritis. Mast cells and the synovial mesenchyme The synovial mesenchyme, consisting principally of synovial fibroblasts, is prominently involved in joint inflammation. ... via TLRs by synovial constituents with TLR ligand activity, including heat shock protein 60 and breakdown products of hyaluronan, potentially amplifying any inflammato...

Ngày tải lên: 09/08/2014, 01:24

... inflammatory arthritis. Interestingly, c-Fos overexpression in α v β 3 -deficient osteoclasts substantially rescues the cells’ capacity to organize their cytoskeleton [28]. In contrast, the integrin ... bone in an inflammatory environment has provided new therapeutic targets that are now being assessed in clinical trials. Competing interests The author(s) declare that they have no...

Ngày tải lên: 09/08/2014, 07:20

... to target key cytokines implicated in JIA, including TNFα, IL-1, IL-6 as well as signaling molecules involved in the regulation of B-cell and T-cell lymphocyte responses (Table 4). Although promising ... Wallace CA, Chon Y, Lin SL, Baum- gartner SW, Giannini EH, Pediatric Rheumatology Collaborative Study Group: Safety and efficacy of up to eight years of con- tinuous etanercept therapy...

Ngày tải lên: 09/08/2014, 01:22

... differences, differences in environmental exposures or a combination of both. With increasing obesity, gout is becoming endemic in China. Finally, symptomatic knee osteoarthritis is extremely common in China and ... are usually presented, whereas age-standardized prevalence would often be more informative, especially since rheumatic diseases vary in prevalence by age. An additional...

Ngày tải lên: 09/08/2014, 10:22

Ngày tải lên: 08/08/2014, 21:20

... crystals are injected into subcutaneous air pouches on mice, they induce inflammatory responses of the type seen in human gout. Ex vivo delivery of prostaglandin D synthetase has a strong anti -inflammatory ... division; they transduce synovium very effectively after intra-articular injection [12,13]. Although lentiviruses are being engineered to remain episomal, their human use in rhe...

Ngày tải lên: 09/08/2014, 01:22

... outcome in personality disorders. Br J Psychiatry 1993, 162:299-313. 81. Rosowsky E, Gurian B: Impact of borderline personality disorder in late life on systems of care. Hosp Community Psychiatry ... of symptoms, a 'subsyndrome' [62] of hopelessness, emptiness and fear of intimacy. With these concerns in mind, Benjamin and Linehan proposed to measure therapy's efficacy...

Ngày tải lên: 08/08/2014, 23:21

... changes in HAAP include marked proliferation of synoviocytes in the synovial lining layer, gross infiltration of lymphocytes, and migration of atypical lymphocytes with nuclear indentation into ... osteophytes and definite joint space narrowing. b Scoring was as follows: +/-, minimum staining in one area of the tissue; +, patchy staining involving several areas; ++, moderate diffuse s...

Ngày tải lên: 09/08/2014, 01:23