Báo cáo y học: " Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study" pdf

... sentinel of the syn- ovium, acting immediately in the event of joint trauma by liber- ating an array of proinflammatory mediators. However, MCs also appear to perpetuate the chronic process by their ... and to analysis and interpretation of the data. CDM, a medical writer at AB Science, contributed to data analysis and interpretation and was the main contributor in th...

Ngày tải lên: 09/08/2014, 14:22

... is an alternative to classical therapy was proposed as an alternative therapy in the treatment of ocular toxoplasmosis. The efficacy of the drug was reported in cerebral toxoplasmosis in AIDS ... patients. The dos- age used by Rothova et al was 250mg a day or 500mg every other day and therapy was associated with pyrimethamine 100mg on the first day that was fol- l...

Ngày tải lên: 03/11/2012, 11:01

... oxidase from Paracoccus denitrificans. Nature 376, 660–669. 12. Tsukihara, T., Aoyama, H., Yamashita, E., Tomizaki, T., Yamaguchi, H., Shinzawa-Itoh, K., Nakashima, R., Yaono, R. & Yoshikawa, ... complex of the respiratory chains of mitochondria and many bacteria [1–4]. It catalyzes the reduction of oxygen to water, coupling the free energy of this reaction to the generatio...

Ngày tải lên: 22/02/2014, 07:20

... were calculated from the optical density in the infranatant averaged over a radial range of 0.1 cm in the plateau region using data from the final radial scan. The average optical density due ... homozygous E4/4 phe- notypes [18] may be due to the inability of apoE4 to bind and initiate the clearance of small lipoproteins in plasma. In contrast, the observation...

Ngày tải lên: 08/03/2014, 09:20

... mention the diagnostic methodology and a classification of CRS. CRS is primarily a clinical diagnosis based on history and physical examination. The physi- cal examination of the sinusitis patient ... vis- ible on nasal endoscopy. This imaging modality also provides detailed images of the intricate anatomy of the paranasal sinuses, such as the eth- moid sinuses and th...

Ngày tải lên: 08/08/2014, 20:23

... three activation pathways - classical, alternative, and lectin, initiated via separate mechanisms, and a single terminal pathway that results in a formation of the membrane attack complex and subsequent ... of many human diseases [21-23], including mental * Correspondence: aboyajyan@sci.am 1 Institute of Molecular Biology of the National Academy of Sciences of Armenia...

Ngày tải lên: 08/08/2014, 21:20

... frequently disabling, and hand OA causes pain and function loss in a large percentage of the elderly. Given the aging of the population and the increasing occurrence of obesity in our population, a major ... how OA may be successfully managed. The symptoms of osteoarthritis: pain and instability The pain of OA is activity-related, with pain coming on generally on...

Ngày tải lên: 09/08/2014, 01:22

... disease-modifying therapy is a major determinant of the disease activity attainable in treatment. Background and evidence The pivotal clinical manifestation of RA is a polyarticular synovitis, which is a ... of joint damage, and that disability can be dissected into several components – among them disease activity and joint damage. It has also been revealed that aiming at...

Ngày tải lên: 09/08/2014, 01:22

... showing any efficacy at all in patients with active SpA to earlier treatment with the final aim of inducing remission and preventing structural damage. A curative treatment is not yet available because ... certainly a low awareness of AS among nonrheumatologists and it can be seen as a major challenge for any physician in primary care to think of and to identify patien...

Ngày tải lên: 09/08/2014, 01:22

... with a variety of proteins within the cytoplasm and to play a key role in the modulation of inflammation and apoptosis [11]. Many of its interactions appear to involve its 90-amino acid N-terminal ... elucidating the pathogenesis of many autoinflammatory diseases has led to major advances in their treatment, most remarkably the introduction of IL-1 inhibition in C...

Ngày tải lên: 09/08/2014, 01:22