Báo cáo y học: "Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis" ppsx

... 3 Research article Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis Manuela ... the association of CCR5 d32 with the inflammatory response, joint erosion, and DNASE2. In the early RA cohort, CRP levels at...

Ngày tải lên: 09/08/2014, 14:21

... at the C-terminus of CCR5 would interfere with the protein’s ability to function as a chemokine receptor or HIV coreceptor, we first determined the binding of MIP-1a to the CCR5- myc-his expressing ... Groningen, the Netherlands) in order to obtain a recombinant protein containing the C-myc epitope followed by six histidines at the C-terminus. A plasmid containing...

Ngày tải lên: 08/03/2014, 09:20

... concentrations in combination with the presence of actin and gelsolin-actin complexes in synovial fluids suggest a local consumption of this potentially anti -inflammatory protein in the inflamed joint. Introduction Plasma ... clearing actin from synovial joints of rheumatoid arthritis patients with acute joint effusionProposed model of plasma gelsolin (pGSN) fu...

Ngày tải lên: 09/08/2014, 13:22

... joint. Our findings are in agreement with the observation that CXCR3, a cell surface receptor for the proinflammatory chemokines inducible protein (IP)-10 and monokine induced by interferon-γ ... Proinflammatory cytokines that induce a high acute phase response also favour the recruitment of a diverse memory T cell reper- toire to the joint, independent of the antigen...

Ngày tải lên: 09/08/2014, 01:23

... Biol Ther 2003; 2: 491-9. 16. Huang S, Shao G, Liu L. The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in ... types of PRDMs have been identified in humans [15, 18]. Most of them are located near the N-terminal portion of the proteins followed by zinc-fingers, and are involved...

Ngày tải lên: 25/10/2012, 11:15

... completely destroyed, and ultrastructures could not be identified. Biochemistry parameters In the present study, the amylase levels in the serum and urine were increased in the first 3 days and the ... irregular, and bulky. A narrow region w i t h inflammatory cell infiltration, consisting primarily of lymphocytes and monocytes sometimes with small number...

Ngày tải lên: 25/10/2012, 11:18

... the catalytic site in the N-terminal domain of one subunit and the substrate recognition site in the C-terminal domain of the other face each other, thereby bringing together the substrate-binding ... (Arg405, Lys407, Lys413, Lys414, Lys422, Lys428, and Lys430) oriented in the same direction with the heparin-binding domain at the N-terminal end [14]. The ot...

Ngày tải lên: 21/02/2014, 15:20

... alignment of the interdomain and autolysis loops of mammalian chymotrypsins and trypsins. The enzyme that was used in this study, rat chymotrypsin B, is highlighted by bold type. The loops are boxed and ... in the interdomain and autolysis loops in the inactivation of chymotrypsin. At first, D-chymo- trypsin and the interdomain and autolysis loop mutants wer...

Ngày tải lên: 22/02/2014, 07:20

... with binding resulting in receptor dimerization, activation of the intrinsic receptor tyrosine kinase, and initiation of intracellular signal transduction [14]. Although the EGFR is the primary site ... standard cysteine residue in the DYANA library [53]. A pseudoatom was included instead of the HG atom and a bridge was formed by superimposition of the pseudo...

Ngày tải lên: 22/02/2014, 07:20

... other, indicating a substantial perturbation of the axial symmetry of the tensor, whereas axial symmetry, i.e. g xx % g yy << g zz is typically found for type 2 sites. The grouping of the g-values ... Egmond 1 and Martina Huber 3 1 Unilever Research Vlaardingen, the Netherlands; 2 University of Groningen, Laboratory of Biophysical Chemistry, Groningen, the Nether...

Ngày tải lên: 22/02/2014, 07:20