Báo cáo y học: "Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis" ppsx
Báo cáo y học: "Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis" ppsx
... 3Research articleNegative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritisManuela ... the association of CCR5 d32 with the inflammatory response, joint erosion, and DNASE2. In the early RA cohort,CRP levels at the onset of disease were determined. Patientscarrying the deletion ... remain conflicting [6]. The goal of our study was, therefore, to investigate the influ-ence of the CCR 5d32 deletion on disease susceptibility and on the clinical course of RA in a large and clinically...
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Báo cáo Y học: Functional reconstitution of the HIV receptors CCR5 and CD4 in liposomes pot
... at the C-terminus of CCR5 would interfere with the protein’sability to function as a chemokine receptor or HIVcoreceptor, we first determined the binding of MIP-1a to the CCR5- myc-his expressing ... Groningen, the Netherlands) in order to obtain a recombinant proteincontaining the C-myc epitope followed by six histidines at the C-terminus. A plasmid containing the wild type version of CCR5 ... glycosaminoglycans [37].As the myc-his tag of the protein was present at the C-terminus of the receptor which is located on the inside of the cell, we then determined if signal transduction bythe...
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Báo cáo y học: "Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis" docx
... concentrations in combination with the presence of actin and gelsolin-actincomplexes in synovial fluids suggest a local consumption of thispotentially anti -inflammatory protein in the inflamed joint. IntroductionPlasma ... clearing actin from synovial joints of rheumatoid arthritis patients with acute joint effusionProposed model of plasma gelsolin (pGSN) function in clearing actin from synovial joints of rheumatoid ... survival and prevent complications of acute injury[12,14,20]. The beneficial effect of pGSN in these settings isunclear but may reside in its binding and/ or inactivation of inflammatory mediators...
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Báo cáo y học: " An association between the acute phase response and patterns of antigen induced T cell proliferation in juvenile idiopathic arthritis" ppt
... joint. Our findings are in agreement with the observation thatCXCR3, a cell surface receptor for the proinflammatorychemokines inducible protein (IP)-10 and monokineinduced by interferon-γ ... Proinflammatorycytokines that induce a high acute phase response alsofavour the recruitment of a diverse memory T cell reper-toire to the joint, independent of the antigen specificity of the ... repertoire and the acute phase response suggests that proinflammatory cytokinesmay influence recruitment of memory T cells to an inflammatory site, independent of their antigen specificity. Additionally,increased...
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Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"
... Biol Ther 2003; 2: 491-9. 16. Huang S, Shao G, Liu L. The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in ... types of PRDMs have been identified in humans [15, 18]. Most of them are located near the N-terminal portion of the proteins followed by zinc-fingers, and are involved in the reg-ulation of ... domain of human retinoblastoma pro-tein-binding zinc finger protein 1 (RIZ1). Int J Mol Sci 2008; 9: 943-50. 21. Chen L, Ling B, Alcorn J, Yang J. Analysis of the expression of human N-myristoyltransferase...
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Báo cáo y học: " Experimental ablation of the pancreas with high intensity focused ultrasound (HIFU) in a porcine model"
... completely destroyed, and ultrastructures could not be identified. Biochemistry parameters In the present study, the amylase levels in the serum and urine were increased in the first 3 days and the ... irregular, and bulky. A narrow region w i t h inflammatory cell infiltration, consisting primarily of lymphocytes and monocytes sometimes with small number of eosinocytes, were seen between the ... c a r r i e d out in compliance with the guide for the care and use of laboratory animals from the Ministry of Science and Technology of the People’s Republic of China. Instruments HIFU ablation...
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Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
... the catalytic site in the N-terminal domain of one subunit and the substrate recognition site in the C-terminal domain of the other face each other, thereby bringing together the substrate-binding ... (Arg405, Lys407,Lys413, Lys414, Lys422, Lys428, and Lys430) oriented in the same direction with the heparin-binding domain at the N-terminal end [14]. The other is a cluster of tryptophans(Trp390, ... HSPG binding at the cell surface is required for maintaining LPL stability.LPL’s C-terminal domain also appears to be involved in the binding of the enzyme to receptors such as the LDLreceptor...
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Tài liệu Báo cáo Y học: Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin pdf
... alignment of the interdomain and autolysis loops of mammalian chymotrypsins and trypsins. The enzyme that was used in this study, ratchymotrypsin B, is highlighted by bold type. The loops are boxed and ... in the interdomain and autolysis loops in the inactivation of chymotrypsin. At first, D-chymo-trypsin and the interdomain and autolysis loop mutants weresubjected to digestion with trypsin. For ... 2).Finally it is of interest regarding the in vivo mechanism of inactivation, that chymotrypsin and trypsin, mixed in concentration ratios close to those in the intestines, did notexpedite the inactivation...
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Tài liệu Báo cáo Y học: Solution structure of the mEGF/TGFa44250 chimeric growth factor doc
... with binding resulting in receptor dimerization, activation of the intrinsic receptor tyrosinekinase, and initiation of intracellular signal transduction[14]. Although the EGFR is the primary site ... standardcysteine residue in the DYANA library [53]. A pseudoatomwas included instead of the HG atom and a bridge wasformed by superimposition of the pseudoatoms on the SGatoms of the other Cys residue, ... NOESY cross peak, or cluster of overlapping peaks,was integrated using the programXEASY [42] together with areas of baseline either side of the peak in the F1dimensionto correct any offset....
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Tài liệu Báo cáo Y học: EPR characterization of the mononuclear Cu-containing Aspergillus japonicus quercetin 2,3-dioxygenase reveals dramatic changes upon anaerobic binding of substrates potx
... other,indicating a substantial perturbation of the axial symmetry of the tensor, whereas axial symmetry, i.e. gxx% gyy<< gzzis typically found for type 2 sites. The grouping of the g-values ... Egmond1 and Martina Huber31Unilever Research Vlaardingen, the Netherlands;2University of Groningen, Laboratory of Biophysical Chemistry,Groningen, the Netherlands;3Department of Molecular Physics, ... the resolved features of the minorspecies in the native enzyme spectra at pH 6.0. The difference in A//values of 6% can be attributed touncertainties in determining the line-position of the...
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