Báo cáo y học: "Toll-like receptors and NOD-like receptors in rheumatic diseases" pdf

... enzyme studied by this group is aromatic amine dehydrogenase. This enzyme is especially interesting because it is fairly nonspecific in the substrates it will bind and catalyze. In particular, in ... particular, in the series benzylamine, dopamine, and tryptamine, primary kinetic isotope effects range from a low of 4.8 in benzylamine to a high of 54.7 in tryptamine [58]. In a...

Ngày tải lên: 31/03/2014, 23:20

... Scale (GDS), and information was obtained on age, ethnicity, level of education, living arrangement, and psychiatric history. Two days post-admission, a clinical staff member caring for each ... hospitalized elderly adults will continue to in- crease in the coming decades. The National Health Inter- view Survey reports that in the United States in 1994, 8.3 million individuals ove...

Ngày tải lên: 08/08/2014, 20:23

... NMDA receptors [18]. They play distinct physiological tasks from fine tuning membrane excitability in response to sensory input, modulating locomotion and emotional behavior to the induction of synaptic ... channels in aged mice may represent a mechanism that contributes to age-dependent decline in learning and memory and synaptic plasticity. In the hippocampus, SK3 was found...

Ngày tải lên: 08/08/2014, 21:20

... Bland RC, Danyluk L: Self-inflicted eye injuries and self-inflicted blindness. J Nerv Ment Dis 1979, 167:311-314. 8. Finkenbine R: Assaultive eye injury and enucleation. J Am Acad Psychiatry ... his home and finding no reason to con- tinue living. According to his description, the injury to his right eye was performed during one of these days in order to "change things" and...

Ngày tải lên: 08/08/2014, 21:20

... tolerance in the thymus. Competing interests None declared. References 1. Delon J, Stoll S, Germain RN: Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue. ... CD4 + T cells directly, IL-1β has been shown by several groups to act on the DC to enhance the production of proinflammatory cytokines, including TNFα and more significantly...

Ngày tải lên: 09/08/2014, 01:23

Ngày tải lên: 09/08/2014, 07:20

... blood or synovial fluid lymphocytes induced TNF production by monocytic cells within 24 hours, an effect that was mainly mediated by NK cells. In turn, monocytic cells induced CD69 expression and IFN-γ ... 2:364-371. 8. Choy EH, Panayi GS: Cytokine pathways and joint inflamma- tion in rheumatoid arthritis. N Engl J Med 2001, 344:907-916. 9. Isler P, Vey E, Zhang JH, Dayer JM: Cell sur...

Ngày tải lên: 09/08/2014, 08:22

... many factors that are also released by macrophages, lymphocytes and fibroblasts indicates that they can play similar roles in chronic inflammation. Many of these factors are pivotal in causing tissue ... RANK, by these cells could provide a large, transient increase in RANKL levels in the joint, supplementing that normally provided by the chronic inflammatory cells in synovial tis...

Ngày tải lên: 09/08/2014, 10:20

... DA: The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest 1999, 103:1227-1230. 4. Osorio YFJ, Bukulmez H, Petit-Teixeira ... Res Ther 2007, 9:R63. 2. Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, Cheresh DA: Definition of two angiogenic pathways by distinct alpha v integrins. Science 1995, 270:15...

Ngày tải lên: 09/08/2014, 10:21

... SF inflammatory mediators, MMP activity and cartilage biomarkers in healthy joints. In short, prostaglandin E 2 , substance P, bradykinin and MMP activity rise shortly after induction of inflammation; ... horses and a transient inflammatory stimulus may limit Figure 2 Synovial fluid inflammatory mediators and matrix metalloproteinase activity in inflamed jointsSynovial fluid inf...

Ngày tải lên: 09/08/2014, 13:22