Báo cáo y học: "Predicting the future of anti-tumor necrosis factor therapy" potx

... informa- tive sets of genes whose expression changes during therapy Editorial Predicting the future of anti-tumor necrosis factor therapy Cornelis L Verweij Division of Inflammatory Disease Profiling, ... costs for therapy, there is a strong need to make predictions on success before the start of therapy. In the current issue of Arthritis Research & Therapy, Hueber...

Ngày tải lên: 09/08/2014, 14:21

... anticipated. These factors significantly reduced the power of the study. Based on their findings, the authors estimate that more than 100 hospitals would be needed to show the 30% difference they sought. ... goal of identifying and treating patients early in the course of their illness is preferable to waiting until more serious signs and symptoms have developed. Certain...

Ngày tải lên: 25/10/2012, 10:39

... indepen- dent of each other. Fluency was judged directly by the assessors, while adequacy was meant to assess the content of the sentence compared to a human gold-standard. Yet, the assessments of the ... influenced by many factors. The way the sentence fits in the con- text of surrounding sentences is one obvious factor (Barzilay and Lapata, 2008). Another well-known...

Ngày tải lên: 22/02/2014, 02:20

... although the HGGG loop was a critical structural element for the catalytic efficiency of the enzyme, the cold adaptation of the enzyme could not be attributed to the presence of the Gly cluster ... G261A/ Y2 69A designed on the basis of side-chain packing criteria from a modelled structure of the enzyme resulted in restor- ation of the energy of activation to...

Ngày tải lên: 22/02/2014, 04:20

... the content of secondary structure only after the disruption of the native tertiary structure of RNase A (Figs 2–4). Interestingly, the preservation of the tertiary structure coincides with the ... hydro- chloride (GdnHCl), urea or elevated temperatures, they destroy the tertiary structure of proteins which results in the loss of enzymatic activity. Regarding the...

Ngày tải lên: 22/02/2014, 07:20

... when studying the catalytic efficiency for these mutants in the diaphorase reaction, all of them yield values very close to those of the wild-type enzyme at the different ionic strengths assayed (within ... FNR the side-chain of E139 might influence the properties of the flavin, assuming some of the functions carried out by E301 in the wild-type enzyme [22]. In this c...

Ngày tải lên: 31/03/2014, 08:20

... complement of chromosomes. The fidelity of chromosome transmission is enhanced not only by the geometry of stable centromere–MT interac- tions, but also by the action of a centromere-based regulatory system ... way, the critical connections that hold sisters together from S phase through early mitosis are literally cut by Ômolecular scissorsÕ in the form of Esp1/separase at...

Ngày tải lên: 31/03/2014, 21:21

... n3 ha-1yr-1 for the typical site. The 95% Cl for the mean GYC for the site ranged from ±0.7 for the typical site to ±2.4 m3 ha-1yr-1 for the high yielding site. The range ... the sum of the angles to the horizon at the 8 cardinal points of the com- pass) was the single most significant factor affecting productivity, explaini...

Ngày tải lên: 08/08/2014, 19:21

... for the clinician to be comfortable with the side-effect profile and be able to discuss potential safety concerns regarding these therapies. Among the safety concerns with the use of INCs are the ... allergies are ‘ the most common chronic condition in Canadians 12 years of age and older.’’ 1 In one study, 42% of children were diagnosed with AR by the age of 6 years. The...

Ngày tải lên: 08/08/2014, 21:20

... 1 Institute of Psychiatry, University of Bologna, Italy, 2 Department of Psychology, Catholic University, Milan, Italy and 3 Department of Psychiatry, San Raffaele Scientific Institute, Milan, Italy Email: ... bipolar disorder of Mr. A daughter strengthen the genetic hypoth- esis. On the contrary, only Mrs. B mother aunt was affected by depression and anxiety, pharmacologica...

Ngày tải lên: 08/08/2014, 21:20