Báo cáo y học: "Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis" ppt

... Sox9 staining patterns were mainly nuclear in normal cartilage (Figure 2), but Sox9 staining in OA clusters was present in both the cytoplasm and nucleus, or Figure 3 Stem cell markers in human ... (OA) articular cartilageStem cell markers in human osteoarthritis (OA) articular cartilage. (a) Safranin O and Notch-1 staining in clusters (10× and 40×). (b) Sa...

Ngày tải lên: 09/08/2014, 14:21

... expression [7], increasin g protein clearance, reducing the toxicity of the protein, influencing downstream pathways activated by the mutant protein and transplantation [4]. For symp- tom treatment, ... clin ically and genetically very heterogeneous. They are progressive neurodegen- erative diseases that are characterised by cerebellar ataxia, resulting in unstead y gait, clumsiness,...

Ngày tải lên: 10/08/2014, 10:20

... and sucrose enzyme inhibitors (amylase and sucrase) would diminish and/ or slow the breakdown of starch and sucrose in the gastrointestinal tract, diminishing glucose entrance into the blood ... dosing, the inhibitors were quite effective in lowering the appearance of glucose in the circulation after sucrose and starch challenges alone and in combination. Accordingly...

Ngày tải lên: 08/08/2014, 16:23

... In turn, insulin resistance is associated with many troublesome, age-related perturbations including hypertension, dyslipidemias, diabetes, obesity and even premature aging [4-7]. Yudkin and ... responsible in many cases for obesity and connected dysfunctions in insulin metabolism with many other aspects of the metabolic syndrome. While aging is associated with insulin resi...

Ngày tải lên: 08/08/2014, 16:23

... total numbers of syn- ovial cells and the numbers of positively stained cells in each immunohistochemical staining using a magnification of 200× or by counting positively stained cells per high ... by proinflammatory cytokines, which not only induce but also maintain synovitis and therefore play an important role in pro- gressive joint destruction [1,2]. Several cytokines are currentl...

Ngày tải lên: 09/08/2014, 07:20

... phosphor- ylated in both the carboxyl-terminal and amino-terminal regions by a kinase in the MEKK1 pathway, resulting in increased acetylase activity [33]. In the present study, caMEKK1 increased NF-κB, ... transcription factors, including Sox9, NF-κB and RARs, for full activity. In the present study, ectopic expression of p300 increased basal Sox9 activity. Moreover, increasing...

Ngày tải lên: 09/08/2014, 10:22

... polypeptide secretion unit consisting of an inner-membrane protein from the ATP-binding cassette ABC-type family, which has a dis- tinctive amino-terminal proteolytic domain of the C39 cysteine ... reaction in DH5α and selection on plates containing kanamycin (cassette in the mini-transposon) and spectinomycin (cassette in the target vector), target plasmids with an inserted mini-tr...

Ngày tải lên: 09/08/2014, 20:20

... replicating within a host consists of independently evolving and interacting sub-populations that can be genetically distinct within anatomical compartments. HIV replicating within the brain causes ... AB, Levy JK, Ryan E, Soukup VM, Hinkin CH, Lazzaretto D, Cherner M, Marcotte TD, et al: Interrater reliability of clinical ratings and neurocognitive diagnoses in HIV. J Clin Exp Neuropsy...

Ngày tải lên: 10/08/2014, 05:21

... of doxycyclin. At t ¼ 0, cells were washed and transferred in the same medium in the absence of doxycyclin. At the indicated times, aliquots of 200 cells were plated on YPD + doxycyclin and the ... Wtb2-SOD1 grown in glucose + doxycyclin; (4) Wtb2-SOD1 grown in galactose + doxycyclin; (5) Wtb2-SOD1 grown in glucose ) doxycyclin; (6) Wtb2-SOD1 grown in galactose ) doxycyclin. (...

Ngày tải lên: 23/03/2014, 21:20

... two (group A), four and six (group B) weeks were baseline-corrected by sub- tracting baseline (time 0) followed by division by the baseline values, and finally multiplying by 100% to give the ... rabbit polyclonal antibody raised against the amino acid 622–632 sequence of the α1 chain of human and rat type II collagen. Intra- and inter-assay variations (CVs) were lower than 9% and...

Ngày tải lên: 09/08/2014, 01:22