Báo cáo y học: "Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids" docx

... resonance imaging examinations of the spine in patients with ankylosing spondylitis, before and after successful therapy with inflix- imab: Evaluation of a new scoring system. Arthritis Rheum 2003, ... the road to unraveling the mystery of what MRI bone oedema actually means in RA. The implications are exciting and suggest a new focus for understanding disease pathology and...

Ngày tải lên: 09/08/2014, 08:23

... rheumatoid arthritis (RA) synoviocytes and clinical responseLink between changes in IL-6 and osteoprotegerin (OPG) production by rheumatoid arthritis (RA) synoviocytes and clinical response. Changes, ... bioactivity and clinical responseLink between circulating tumour necrosis factor (TNF)-α bioactivity and clinical response. Using the ability of TNF-α to stimulate r...

Ngày tải lên: 09/08/2014, 06:22

... function in chronic inflammation, to a ‘network concept’ of interacting activities contributing in synergy across distinct tissue events. In particular, cytokine mediated pathology may be distinct in ... complex milieu of regulatory pathways described for IL-18. High affinity binding by IL-18 binding protein a and c isoforms renders these obvious neutralising agents, and early...

Ngày tải lên: 09/08/2014, 06:22

... sources of anti-GAG nAbs. Figure 4 Detection of anti-glycosaminoglycan (GAG) antibody binding to the extracellular matrix of hyaline cartilageDetection of anti-glycosaminoglycan (GAG) antibody binding ... carbohydrate-specific anti- bodies have not yet been systematically investigated in RA, in spite of the fact that hyaline cartilage and synovial fluid contain large amounts...

Ngày tải lên: 09/08/2014, 13:22

... summary, the study by Saad and colleagues gives us important insights into daily-life use of TNF inhibitors in PsA, a disease that too often is secondary to RA in the scientific and clinical ... study: the authors have adopted the methodology of looking at all treatment terminations and then at only those terminations for the reason of ineffectiveness and terminated for the...

Ngày tải lên: 09/08/2014, 14:20

... cen- tral in experiencing and assessing emotions of self and others [10]. These findings are significant as they go beyond the neurobiology of emotions to explain the neu- robiology of empathy. The ... of psy- chotherapy in psychopathy was assessed in a meta-analy- sis by Salekin et al. [65]. They analysed 42 interventional studies for individuals classified as psychopathic...

Ngày tải lên: 08/08/2014, 23:21

... removal of cellular debris by phagocytes. Transient appearance of low affinity anti-single-stranded or dsDNA anti- bodies, preferentially of IgM and IgG 3 isotypes, will probably accompany any systemic ... ligands may need prior processing by DNA-specific enzymes (e.g. helicases and/ or topoisomerases) in order to bind more avidly to the TLR9 and to initiate downstream signaling....

Ngày tải lên: 09/08/2014, 07:20

... factor C3 in the rheumatoid synovium. These results corroborate the idea that citrullination is intimately involved in the pathophysiology of rheumatoid arthritis and complete our model (the rheumatoid ... suggesting that they contribute to synovitis in a subset of patients. There are many citrullinated proteins in the inflamed RA synovium [2] - for example, vimentin,...

Ngày tải lên: 09/08/2014, 13:21

... N-terminus of globular adiponectin and the C- terminus of GLP-1-A through the linker, which could make the N-terminus of GLP-1-A and the C-terminus of gAdiponectin be free and interact productively ... and may be a promising agent that can treat type 2 daibetes by improving both insulin resistance and insulin secretion deficiency. However, we only ob- served the glucose...

Ngày tải lên: 25/10/2012, 11:10

... classes. Role of Tyr183 in catalysis In previous crystallographic studies it was shown that the hydroxyl side chain of Tyr183 is within hydrogen bonding distance of the N-acetyl carbonyl oxygen of the ... protein as judged by SDS/ PAGE. The activity of the pure recombinant protein was 80% of that of t he wild-type protein in both the lysozyme and chitinase assays. Attemp...

Ngày tải lên: 22/02/2014, 04:20