Báo cáo y học: "Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritsi" potx

... as regulating neurotrophin expression [29], have recently also Figure 4 NGF staining by flow cytometryNGF staining by flow cytometry. PBMC of (a) healthy controls (HC) and (b) synovial fluid mononuclear ... using flow cytometry. Concomitant staining of cell sur- face markers and intracellular NGF revealed the presence of NGF in T lymphocytes (CD3+) and monocytes (CD14+). In contra...

Ngày tải lên: 09/08/2014, 14:21

... occur through dysregulation of the inhibitory Smad, Smad7, which typically represses TGF-β signaling by interacting with activated TGF-β receptors to prevent the activation of Smad2/3 and/ or by interfering ... the type I and type II TGF-β serine–threonine kinase receptors, TβRI and TβRII. Interaction of the TGF-β ligand with these receptors on target cells engages a signaling cascade pr...

Ngày tải lên: 09/08/2014, 06:22

... embedded in paraffin. Sections were stained with hematoxylin and eosin and examined by light microscopy. Flow cytometry Cell suspensions were prepared in PBS containing 1% fetal calf serum and 0.1% ... hepatocyte growth factor (HGF) on mononuclear infiltration in the liver and the salivary glandsInhibitory effect of hepatocyte growth factor (HGF) on mononuclear infiltrat...

Ngày tải lên: 09/08/2014, 08:22

... T: Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study. Am J Respir Crit Care ... embedded in paraffin. Sections were stained with hematoxylin and eosin and were examined by light microscopy. RT-PCR RNA was extracted using an Isogen (Nippongene, Toyama, Japan) kit,...

Ngày tải lên: 09/08/2014, 08:22

... grading system are presented in Figure 1. Quantification of inflammatory cytokines in synovial fluid Cytokine profiles in synovial fluid were determined using a BD™ cytometric bead array (BD ... of therapeutic indications, including anti-inflammatory and analgesic effects. The endocannabinoid receptor system, including the cannabinoid receptor 1 (CB 1 ) and receptor 2 (CB 2 )...

Ngày tải lên: 09/08/2014, 10:23

... activity in daily clinical practice in a similar way to ran- domized clinical trials. Disappointingly, we could not observe the amazing halt of radiological progression described in clin- ical ... disease course, however, and in the event they suffered a RA worsen- ing or a flare up they were probably switched to another DMARD, instead of using gold as an add-on therapy. Regarding c...

Ngày tải lên: 09/08/2014, 13:22

... 1478-6362) Abstract X-ray evaluation of rheumatoid joints is relatively inexpensive, is widely available and has standardised methods for interpretation. It also has limitations, including the inability to reliably ... damage to joints in rheumatoid arthritis (RA) is essential in both routine clinical management and clinical trials. But does conventional radiography (CR) remain...

Ngày tải lên: 09/08/2014, 01:23

... Combination Therapy Trial Group: Delay to institution of therapy and induc- tion of remission using single-drug or combination-disease- modifying antirheumatic drug therapy in early rheumatoid arthritis. Arthritis ... JM: Consequences of delayed therapy with second-line agents in rheumatoid arthritis: a 3 year followup on the hydroxychloroquine in early rheumatoid arthriti...

Ngày tải lên: 09/08/2014, 01:23

... participated in gene expression data processing and in study design and coordination. CK and MS conceived the study and partici- pated in its design and coordination. All authors read and approved the final ... cyclooxygenase-2), the NF-κB signaling pathway (toll-like receptor 2, spermine synthase, receptor- interacting serine-threonine kinase 2), cytokines/ chemokines...

Ngày tải lên: 09/08/2014, 10:22

... Stastny P: Mixed lymphocyte cultures in rheumatoid arthritis. J Clin Invest 1976, 57:1148-1157. 4. Korendowych E, Dixey J, Cox B, Jones S, McHugh N: The Influ- ence of the HLA-DRB1 rheumatoid arthritis ... collaborators from the rheumatoid arthritis international working group, for clinical data management and laboratory typings. The authors are indebted to patients and con...

Ngày tải lên: 09/08/2014, 10:23