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Báo cáo y học: "Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritsi" potx

Báo cáo y học:

Báo cáo y học: "Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritsi" potx

... asregulating neurotrophin expression [29], have recently alsoFigure 4NGF staining by flow cytometryNGF staining by flow cytometry. PBMC of (a) healthy controls (HC) and (b) synovial fluid mononuclear ... using flow cytometry. Concomitant staining of cell sur-face markers and intracellular NGF revealed the presence ofNGF in T lymphocytes (CD3+) and monocytes (CD14+). In contrast, B lymphocytes ... functional investigation of their activeinvolvement in chronic inflammatory arthritis. IntroductionThere is increasing evidence for the presence of neuronal growth factors in chronic inflammatory arthritis. ...
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Báo cáo y học: "β Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases" potx

... occurthrough dysregulation of the inhibitory Smad, Smad7,which typically represses TGF-β signaling by interactingwith activated TGF-β receptors to prevent the activation ofSmad2/3 and/ or by interfering ... the type I and type II TGF-β serine–threoninekinase receptors, TβRI and TβRII. Interaction of the TGF-βligand with these receptors on target cells engages asignaling cascade precipitated by the ... formationbetween Smad2/3 and Smad4 [45]. Facilitating theinhibitory Smad signals are the Smad ubiquitin regulatoryfactors (Smurfs), E3 ubiquitin ligases, capable of inducingpolyubiquitination and degradation...
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Báo cáo y học: " Hepatocyte growth factor prevents lupus nephritis in a murine lupus model of chronic graft-versus-host disease" ppt

... embedded in paraffin. Sections were stained with hematoxylin and eosin and examined by light microscopy.Flow cytometryCell suspensions were prepared in PBS containing 1% fetalcalf serum and 0.1% ... hepatocyte growth factor (HGF) on mononuclear infiltration in the liver and the salivary glandsInhibitory effect of hepatocyte growth factor (HGF) on mononuclear infiltration in the liver and the ... erythematosus, primary biliary chirrho-sis, and Sjogren's syndrome, which are characterized by lym-phocyte infiltration into organs such as the kidneys, liver and salivary glands [6]. In contrast,...
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Báo cáo y học: "Hepatocyte growth factor ameliorates dermal sclerosis in the tight-skin mouse model of scleroderma" doc

... T: Simultaneousor delayed administration of hepatocyte growth factor equallyrepresses the fibrotic changes in murine lung injury inducedby bleomycin. A morphologic study. Am J Respir Crit Care ... embedded in paraffin. Sections were stained with hematoxylin and eosin and were examined by light microscopy.RT-PCRRNA was extracted using an Isogen (Nippongene, Toyama,Japan) kit, according to ... Rheumatology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan2Division of Hematology, Department of Internal...
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Báo cáo y học: "Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis" pdf

... grading system are presented in Figure 1.Quantification of inflammatory cytokines in synovial fluidCytokine profiles in synovial fluid were determined using aBD™ cytometric bead array (BD ... oftherapeutic indications, including anti-inflammatory and analgesic effects. The endocannabinoid receptor system,including the cannabinoid receptor 1 (CB1) and receptor 2(CB2) and the endocannabinoids, ... ability to modulatethe endocannabinoid system [20,21]. The endocannabinoids and PEA are synthesised on demand, and AEA, PEA, and OEA are metabolised predominantly by fatty acid amide hydro-lase...
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Báo cáo y học: "Trends towards an improved disease state in rheumatoid arthritis over time: influence of new therapies and changes in management approach: analysis of the EMECAR cohort" ppt

... activity in daily clinical practice in a similar way to ran-domized clinical trials. Disappointingly, we could not observethe amazing halt of radiological progression described in clin-ical ... diseasecourse, however, and in the event they suffered a RA worsen-ing or a flare up they were probably switched to anotherDMARD, instead of using gold as an add-on therapy.Regarding cyclosporin A treatment, ... COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a briefintervention. Arthritis Rheum 2002, 46:347-356.15. Young A: Early rheumatoid arthritis. ...
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Báo cáo y học: "The value of sensitive imaging modalities in rheumatoid arthritis pdf

... 1478-6362)AbstractX-ray evaluation of rheumatoid joints is relatively inexpensive, is widely available and has standardisedmethods for interpretation. It also has limitations, including the inability to reliably ... damage tojoints in rheumatoid arthritis (RA) is essential in bothroutine clinical management and clinical trials. But doesconventional radiography (CR) remain the gold-standardmethodology for assessment ... The early post-gadolinium synovial membraneenhancement in RA joints, determined by dynamic MRI, isconsidered to reflect synovial perfusion and permeability.However, the image quality, and therefore...
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Báo cáo y học: "Evidence for early disease-modifying drugs in rheumatoid arthritis" pps

... CombinationTherapy Trial Group: Delay to institution of therapy and induc-tion of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis. Arthritis ... JM: Consequences ofdelayed therapy with second-line agents in rheumatoid arthritis: a 3 year followup on the hydroxychloroquine in early rheumatoid arthritis (HERA) study. J Rheumatol 2000 27:623-629.10. ... monother-apy, and median X-ray damage had increased by 1 Sharpunit with combined therapy and by 4 Sharp units withmonotherapy. Five years later the benefits of combinationtherapy on joint damage...
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Báo cáo y học: "Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study" docx

... participated in gene expression data processing and in study design and coordination. CK and MS conceived the study and partici-pated in its design and coordination. All authors read and approved the final ... cyclooxygenase-2), the NF-κBsignaling pathway (toll-like receptor 2, spermine synthase, receptor- interacting serine-threonine kinase 2), cytokines/chemokines and receptors (CXCL1–3, CXCL8, CCL20,CXCR4, ... genes, some cytokines/chemok-ines and receptors were induced, such as granulocyte colony-stimulating factor 3 (CSF3), IL-23A and hepatocyte growth factor receptor (Met), the chemokines CXCL1–3...
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Báo cáo y học: "New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: a combined analysis of worldwide samples" docx

... Stastny P: Mixed lymphocyte cultures in rheumatoid arthritis. JClin Invest 1976, 57:1148-1157.4. Korendowych E, Dixey J, Cox B, Jones S, McHugh N: The Influ-ence of the HLA-DRB1 rheumatoid arthritis ... collaborators from the rheumatoid arthritis international working group, for clinical data management and laboratory typings. The authors are indebted to patients and controls for their kind participation. ... was previously analyzed in terms of RA severity and in terms of autoantibody production such as anti-cyclic citrulli-nated peptide (anti-CCP) antibodies and anti-deiminatedhuman fibrinogen autoantibodies....
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