Báo cáo y học: "Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthriti" pps

... 3 Research article Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis Wolfgang Hueber 1,2 , Beren H Tomooka 1,2 , Franak Batliwalla 3 , ... autoantibodies and cytokines provides clinical utility for predicting response to the anti-TNF therapy etanercept in RA patients. Introduction Rheuma...

Ngày tải lên: 09/08/2014, 14:21

... Chemokines, as well as other inflammatory mediators, appear to play key roles in the pathogenesis of RA, and the co-ordinated production of chemokines and proinflammatory cytokines is probably important ... significantly inhibited IP-10 induction. These results suggest that IP-10 expression within inflamed joints appears to be regulated not only by inflammatory cytokines but also by...

Ngày tải lên: 09/08/2014, 01:21

... controlled by proinflammatory cytokines and increased responses to TLR ligands. GM-CSF was shown to play an important role in inflammatory sig- naling in a model of LPS-induced lung injury. Pre- treatment ... human innate immune system. Proinflammatory cytokines, such as granulo- cyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF),...

Ngày tải lên: 08/08/2014, 16:23

... NH, Song YS. XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine poly- morphisms are associated with response to platinum-based neoad- juvant chemotherapy in cervical cancer. Gynecol Oncol. ... stud- ies is increasing rapidly and this trend is expected to accelerate due to the availability of mapped sin- gle-nucleotide polymorphisms (SNP) in the human genome and advan...

Ngày tải lên: 25/10/2012, 10:51

... apoenzyme was divided into aliquots and stored at 2 70 8C until use. Enzyme assays BLXI activity was assayed routinely with glucose as the substrate. The enzyme (0.06 mg·mL 21 ) was incubated in q ... & Ringe, D. (1994) Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid. Biochemi...

Ngày tải lên: 22/02/2014, 07:20

... solubilized in dodecylmaltoside to be obtained, and, increased t he stability o f the rec eptor solubilized in other alkylmaltosides. Puri®cation to homogeneity was achieved in three steps, including ... ligands allows the structural integrity and homogeneity of a puri®ed receptor p rotein to be judged. The M-A2aTr316-H10 fusion protein displayed high af®nity binding to all l...

Ngày tải lên: 24/03/2014, 00:21

... CKBM could induce cytokine release including TNF-α in these animals and inhibit tumor growth. However, further study is needed to determine how they are induced and the mechanisms they inhibit ... proliferation and promotion of apoptosis in this model. Dietary supplement containing Schisandra chinensis has been shown to reduce prostate cancer cell growth and induce apopt...

Ngày tải lên: 08/08/2014, 18:20

... heat- inactivated FCS, penicillin (50 units/ml), and streptomycin (50 µg/ml). At 2 days before cell sampling and/ or cell stimulation by cytokines, FCS was replaced by ITS (insulin, transferrin, and ... results in thyrosine phosphoryla- tion and an increase in intracellular calcium [17]). Glycosylphosphatidylinositol-anchored proteins involved in signaling are often associated wi...

Ngày tải lên: 09/08/2014, 06:22

... by chondrocytes, synovial cells, and other cells of the skeleton. Its synthesis is increased in chondrocytes and in synovial cells when activated by proin- flammatory cytokines [37]. Preliminary ... The inability to detect an increase may be related to the number of joints involved in OA (joint load) compared with RA [19,28]. Alternatively, it may be because, in serum, we are...

Ngày tải lên: 09/08/2014, 10:21

... contain one or more SNPs in their coding regions. SNP and nsSNP denote synonymous and non-synonymous SNPs, respectively. OMIM, Online Mendelian Inheritance in Man. Fang et al. Genome Biology 2011, ... coding SNPs in protein domains [28], was used to s earch for SNPs located in the same domains using macaque orthologs as the query. In total, 671 unique nonsynonymous SNPs were d...

Ngày tải lên: 09/08/2014, 23:20