Báo cáo y học: "Different properties of ACPA and IgM-RF derived from a large dataset: further evidence of two distinct autoantibody systems" potx

... final manuscript. References 1. Nishimura K, Sugiyama D, Kogata Y, Tsuji G, Nakazawa T, Kawano S, Saigo K, Morinobu A, Koshiba M, Kuntz KM, Kamae I, Kumagai S: Meta-analysis: diagnostic accuracy ... 1 of 6 (page number not for citation purposes) Vol 11 No 3 Research article Different properties of ACPA and IgM-RF derived from a large dataset: further evidence of...

Ngày tải lên: 09/08/2014, 14:21

... polyps as well as the risk of advanced adenomas at one and three years after randomization [5]. Use of immune modulating therapies in RA may also underlie the observed reduction in breast cancer incidence, ... mechanism is not clear. The important meta-analysis presented by Smitten and colleagues pushes our understanding of malignancy in RA forward but raises many important question...

Ngày tải lên: 09/08/2014, 10:23

... Shioda T, Kato H, Ohnishi Y, Tashiro K, Ikegawa M, Nakayama EE, Hu H, Kato A, Sakai Y, Liu H, et al.: Anti-HIV-1 and chemotactic activities of human stromal cell -derived factor 1alpha (SDF- 1alpha) ... factors in the pathogenesis of rheumatoid arthritis? Aleksi Sedo 1 , Jonathan S Duke-Cohan 2 , Eva Balaziova 1 and Liliana R Sedova 3 1 Laboratory of Cancer Cell Biology of the...

Ngày tải lên: 09/08/2014, 07:20

... 5'-TTCCTGGGCATGGAGTCCT-3' Antisense 5'-AGGAGGAGCAATGATCTTGATC-3' Mouse TNFα Sense 5'-CATCTTCTCAAAATTCGAG-3' Antisense 5'-TGGGAGTAGACAAGGTACAACCC-3' Mouse IL-1β Sense 5'-CAACCAACAAGTGATATTCTCCATG-3' Antisense ... 5'-TGAGGAGCAGCACCCAGAGC-3' Antisense 5'-CCGTAGGACTGGAAAGAGGA-3' Human TNFα Sense 5'-GTCTCCTACCAGACCAAG-3&apo...

Ngày tải lên: 09/08/2014, 08:23

... inflammation of the adjacent skeletal muscle (star), which was dominated by neutrophilic granulocytes (small arrow) as a sign of acute inflammation and exhibited activation of synovial fibroblasts ... was used as the substrate, and the optical density was measured at 492 nm. Statistical analysis All data are presented as the mean ± standard error of the mean unless otherwise in...

Ngày tải lên: 09/08/2014, 14:22

... Heart 2000;84:272-6. 10. Hayashida W, Kumada T, Nohara R, Tanio H, Kambayashi M, Ishikawa N, Nakamura Y, Himura Y, Kawai C. Left ventricular regional wall stress in dilated cardiomyopathy. ... cohort of patients evaluated in our hemodynamic laboratory. All of these patients had a normal left ventricular cavity size and baseline ejection fraction as evaluated by radionuclide a...

Ngày tải lên: 05/11/2012, 11:32

... 5¢-TTAGGATCCAGAAAAATGGGG-3¢ and 5¢-AACAAACAGCGGCCGCGGGCACTTTAATCC-3¢ were used in PCR to amplify the coding region of the cDNA and introduce appropriate restriction s ites. The plasmid pFASTBac-1 ... host bacterial strain was XL1-Blue (Stratagene). Northern analysis Approximately 20 lg total RNA were separated in 1.4% agarose gels containing 6.3% formaldehyde and transferred by capill...

Ngày tải lên: 22/02/2014, 04:20

... F., Katagiri, T., Suzuki, M., Watanabe, T.K., Okuno, S., Kuga ,Y. ,Nagata,M.,Fujiwara,T.,Nakamura ,Y. & Takahashi, E . (1997) Cloning and chromosome assignment to 1q32 of a h uman cDNA (RA B7L1) ... was ampli®ed from a platelet Marathon TM cDNA library, using as PCR primers, 5¢-TAGGATCCGCGATACGGGAGC- TCAAAG-3¢ (P31-1) and 5 ¢-ATCTCGAGGATGTGGG- Fig. 1. Nucleotide and deduced...

Ngày tải lên: 08/03/2014, 16:20

... with large variation. This may be attributed to proximity with two basic sites, the N-terminal amide and His2. Aspartic acids Asp27 and Asp30 show lower mean pK a values than their model pK a values. ... While early studies indicated that only the type IIa regulatory subunits are targeted, the recent discovery of dual-specificity AKAPs (D-AKAPs) indicates that the type I enzyme m...

Ngày tải lên: 08/03/2014, 22:20

... aspartic proteases that are enzymatically active at neutral and weakly alkaline pH as follows: renin has an optimum pH of 5.5–7.5 [44]; mouse submandibular renin at pH 6.5–8.3 [45]; and signal ... levels. A typical AP is usually synthesized as a single-chain zymogen and is directed to intracellular compartments. It is generally activated by a self-catalyzed process, by which an...

Ngày tải lên: 17/03/2014, 10:20