Báo cáo y học: "Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblast" potx

... MMPs, proinflammatory cytokines and chemokines [13]. There is increasing evidence that SFs are key players in the pathogenesis of RA by invading and eroding hyaline cartilage. SFs, activated locally, ... expression in both rheumatoid arthritis and osteoarthritis derived synovial fibroblasts. In addition, expression of cartilage- degrading glycosidases was mo...

Ngày tải lên: 09/08/2014, 14:20

... Shin YK, Kim SH, Surh YJ: Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF- kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis 2006, 27(7):1465-1474. 41. ... of the Polygonaceae family that is widely distributed in Asia and North America. Interest in Polygonum cuspidatum (PC) has increased owing to the high concentra...

Ngày tải lên: 11/08/2014, 08:21

... prognosis of the dis- ease. The major obstacles in the human studies are the relatively late diagnosis of RA, the large variety of cell types (cells of the immune system and of synovial joints) involved in ... extremely complex owing to the diversity of cell types involved in the pathology and the polygenic character of the autoimmune disease [1- 5]. The overall pi...

Ngày tải lên: 09/08/2014, 06:22

... described by Nanakumar and coworkers [12], scoring of animals was done blindly using a scoring system based on the number of inflamed joints in each paw, inflammation being defined by swelling and redness. ... the predom- inant adhesion molecule, mediating monocyte binding to inflamed synovial venules [23]. Similarly, increased cellular infiltration and increased expression o...

Ngày tải lên: 09/08/2014, 06:23

... K: Elevation of interleukin-8 (IL-8) levels in joint fluids of patients with rheumatoid arthritis and the induction by IL-8 of leuko- cyte infiltration and synovitis in rabbit joints. Lymphokine Cytokine ... separately with cell-permeable inhibitors of MAP kinase/ERK kinase-1/2 (PD98059), p38 (SB203580), protein kinase C (calphostin C), and tyrosine kinase (genistein), f...

Ngày tải lên: 09/08/2014, 01:22

... findings extended those of other groups (working in MS and SLE) by including patients with RA and IDDM, and by offering direct comparisons between them. The similar gene expression findings in ... largely in oncology, many new reports are emerging in other fields including infectious diseases and pharmacology, and applications in autoimmunity have been recently reporte...

Ngày tải lên: 09/08/2014, 01:23

... Maier JA, Crofford LJ, Case JP, Maciag T, Wilder RL: In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal ... RA is infiltration of leucocytes into synovial tissue medi- ated by a complex network of cytokines, adhesion mole- cules and chemoattractants [18]. Interest...

Ngày tải lên: 09/08/2014, 06:22

... antagonists interfere with many pathways involved in RA synovial inflammatory processes; these include local produc- tion of chemokines and cytokines [6-9], vascular proliferation and endothelial expression ... reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue. Arthritis Rheum 2003,...

Ngày tải lên: 09/08/2014, 14:20

... the expression of SPP1 and CREBBP genes involved in the transforming growth factor (TGF-b) pathway was down 16-fold. Expression levels of TNFSF10, BCL2L1, SPP1, and CREBBP were also examined by ... The BH3-only domain proteins BIK and BNIP3, which were located upstream of BCL-2 (Figure 2), may enhance their binding to BCL-2, thereby inhibiting the anti-apop- totic function....

Ngày tải lên: 10/08/2014, 21:23

... Tomita 1 and Alessandro Giuliani 6 1 Institute for Advanced Biosciences, Keio University, Yamagata, Japan 2 Bioinformatics Institute, Singapore 3 Genome Institute of Singapore, Singapore 4 Physiology ... prevailing view about the interpretation of cellular biology experi- ments that typically are performed on colonies of billions of cells. By ana- lysing gene expression data of...

Ngày tải lên: 30/03/2014, 08:20