Báo cáo y học: "Capturing real-life patient care in psoriatic arthritis and its risks: the challenge of analysing registry data" docx
Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
... thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability Yoshihiro Sambongi1, Susumu Uchiyama2,*, Yuji Kobayashi2, Yasuo Igarashi3 and Jun Hasegawa41Graduate ... and areapplicable to the elucidation of the dynamic features of cytochromes c. It is of interest to characterize cytochrome c with respect to protein maturation, folding, stability, and function ... Although the cytoplasmic holo-(TT c- 552) has the same function and spectra as the authentic one, the cytoplasmic soluble protein fraction also contains a minorproduct, which has a heme attached...
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Báo cáo y học: "Randomized controlled trial design in rheumatoid arthritis: the past decade" docx
... expected in the near future. The FinRaCo (Finnish RA Combination Therapy) [56] trial introduced the paradigm of ‘treating to target’: allowingtherapeutic titration in those not achieving a prespecified ... over the past decade in trial design in RA. These include the following:ã Establishment of a clear regulatory path to demonstrateefficacy of a new therapeuticã The use of pure placebo beyond ... changes in HAQ-DI (from baseline to 6 and12 months) were –0.54 in patients who received combinationtherapy for the entire trial compared with –0.30 in thosereceiving combination therapy only during...
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Báo cáo y học: "Apolipoprotein A-I infiltration in rheumatoid arthritis synovial tissue: a control mechanism of cytokine production" pot
... inhibition of TNF-α and IL-1β production.This study examined the hypothesis that apoA-I may have a regulatory role at sites of macrophage activation by Tlymphocytes in inflamed RA synovial tissue. Synovial ... pathogenesis and themaintenance of chronic inflammation in diseases such asRA. Regulating a potent mechanism that induces both IL-1β and TNF-α may be important in maintaining a low level of monocyte activation ... stimulated T lymphocytes, and this mechanism maybe critical in the pathogenesis of rheumatoid arthritis (RA).Apolipoprotein A- I (apoA-I) blocks contact-mediated activation of monocytes, causing inhibition...
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Báo cáo y học: "ncreased serum HO-1 in hemophagocytic syndrome and adult-onset Still''''s disease: use in the differential diagnosis of hyperferritinemia" docx
... 3Research articleIncreased serum HO-1 in hemophagocytic syndrome and adult-onset Still's disease: use in the differential diagnosis of hyperferritinemiaYohei Kirino1, Mitsuhiro Takeno1, ... YK, MT, and MI, con-ducted the laboratory work. YK, MT, AU, SO, AS, HK, KT, and YI were involved in the analysis and interpretation of data. YK,MT, and YI were involved in writing the report. ... levelswould be useful in the differential diagnosis of hyperferritinemia and perhaps also in monitoring disease activity in HPS and ASD.IntroductionHeme oxygenase (HO) is an enzyme that catalyzes the...
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Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity" pps
... immune sys-tem is further amplified by the results of the analysis of MHC IIT cell epitopes using the ProPred server shown in Fig. 5b.Here we can see that the extremely disordered regions of the virus ... extremely disordered pro-teins. Thus X-ray studies of extremely disordered proteins tendeither to focus on the ordered domains of the proteins that canbe readily crystallized, or are studies of ... Furthermore, because disordered regions are often boundto other proteins or to nucleic acids, they may be masked andphysically unavailable to the immune system [49]. Finally, asshown by the...
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Báo cáo y học: "THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis" pps
... forward 5'-GCCTCTTCT-CATTCCTGCTT-3', reverse 5'-CACTTGGTGGTTT-GCTACGA-3'; for IL-1β, forward 5'-CCCAAGCAATACCCAAAGAA-3', reverse 5'-CATCAGAG-GCAAGGAGGAAA-3'; ... indicating that PPARγ agonists can inhibit activa-tion of monocyte/macrophages [34]. As macrophages initiate the inflammatory process and are the source of manycytokines responsible for cartilage and ... weeks. The clinical disease activity of CIA was determined every other day using a three-point scale for each paw. Data are expressed as mean ± standard error of the mean (n = 10/group; asterisks...
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Báo cáo y học: "CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes" pptx
... synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes Ping Zhu1, Ning Lu1, Zhan-guo Shi1, Jun Zhou2, Zhen-biao Wu1, Yong ... zymography of culture medium conditioned by fibroblast-like synoviocytes (FLS) and monocytes/macrophagesGelatin zymography of culture medium conditioned by fibroblast-like synoviocytes (FLS) and monocytes/macrophages. ... proliferating mass of synoviocytes locally invades the cartilage and bone, destroy-ing the joint. MMPs, mainly produced in FLS, play a central role in arthritic joint destruction. Beyond the proof...
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Báo cáo y học: "NGR1 single nucleotide polymorphisms in rheumatoid arthritis" pdf
... primer).Results and discussion In marked contrast to previous findings, no polymorphic alleles(neither thymine at position 40 nor cytosine at position 1,400)were detected in any of the individuals tested. ... sur-prising because both positions were highly polymorphic in theoriginal publications. In those publications, heterozygosity atposition 40 (V14M) was detected in four individuals (4.4%) in a ... Schrodi SJ, Chokkalin-gam AP, Alexander HC, Ardlie KG, Huang Q, Smith AM, SpoerkeJM, et al.: A missense single- nucleotide polymorphism in agene encoding a protein tyrosine phosphatase (PTPN22)...
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Báo cáo y học: "Remission by composite scores in rheumatoid arthritis: are ankles and feet important" pptx
... assessment in RA. In this study, we showed that theassessment of joint activity in the feet, beyond assessment ofjoint activity by the 28-joint count, does not convey significantadded value in the ... that while providing useful and important clinical information, the inclusion of ankles and feet only rarely influences the definition of overall disease activitystatus, especially the presence ... Joint counts are commonly used to evaluate joint involve-ment and are therefore an indispensable component of formaldisease activity assessment using composite indices.Although principally in...
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Báo cáo y học: " High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease." docx
... neurotoxin.Review High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic diseaseDavid S Pisetsky 1, 2, Helena Erlandsson-Harris3and Ulf Andersson4 1 Division of Rheumatology ... mediated by HMGB1 and RAGE. Nat Immunol 2007, 8:487-496.59. Jiang W, Pisetsky DS: Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupuserythematosus. Ann ... activity of HMGB1 inacute and chronic inflammatory conditions, including the rheumatic diseases. Since HMGB1 may be a target of newtherapy, HMGB1 biology has emerged as a rapidly expandingfield of...
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Báo cáo y học: "Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on" pps
... Changes in the methylation status of ReviewTargeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on?Aleksander ... of HAT activity to HDAC activity may sensitize cells to inflammatory gene transcription via chromatin remodeling,may increase the DNA binding and activity of transcriptionfactors, and may increase ... Recent findings in the study of inflammatory lung diseases demonstrate that HAT activity and HDAC activity significantly impact upon the clinical efficacy of GCtherapy [15]. GC receptor-binding...
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Báo cáo y học: "Capturing real-life patient care in psoriatic arthritis and its risks: the challenge of analysing registry data" docx
... perceivable in this study: the authors have adopted the methodology of looking at all treatment terminations and thenat only those terminations for the reason of ineffectiveness and terminated for the ... withdrawal. In summary, the study by Saad and colleagues gives usimportant insights into daily-life use of TNF inhibitors in PsA, adisease that too often is secondary to RA in the scientific and clinical ... perceptions of rheumatologists. The authors dealeffectively with the challenges posed by the type and origin of their data. Although toxicity and effectiveness analyses seemto favour etanercept and...
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Báo cáo y học: "New role for Agrin in T cells and its potential importance in immune system regulation" ppsx
... biology and make the case for a more thorough and systematic investigation into its role in the immune system. â 2010 BioMed Central LtdNew role for Agrin in T cells and its potential importance ... only an assumption and it remains to be seen whether Agrin plays a role in the INF system. A working hypothesis on the function of Agrin in the immune system Although the number of studies investigating ... expression. Agrin from activated T cells has the capacity to induce aggregation of key receptors and to regulate signalling. Interestingly, T cells isolated from patients with systemic lupus erythematosus...
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Báo cáo y học: "ICUs worldwide: Critical care in India" pdf
... previously mentioned. The certificate course in critical care, the first organized training activity in critical care medicine, was started 4 years ago by the ISCCM and hasbeen evolving well. ... who-is-who in critical care in India,but also many international stalwarts over the past 8 years.Good quality original work has now started emerging, and isbeing accepted for publication by the ... PostDoctoral Fellowship in Critical Care Medicine conducted by the National Board of Examinationshas recently been announced. With this, the first steps fortraining in critical care on a national...
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Báo cáo y học: "Clinical review: Critical care in the global context – disparities in burden of illness, access, and economics" potx
... developing world Of the nearly 6 billion people in the world today, roughly 1billion live in extreme poverty. They are nearly all inhabitants of ‘developing’ countries, predominantly in sub-Saharan ... without the accident of latitude. Tailored to the needs of the region, the provision of critical care has a role,even in the context of limited preventive and primary care. Internationally and locally ... review: Critical care in the global context – disparities in burden of illness, access, and economicsRobert A Fowler1,2, Neill KJ Adhikari2 and Satish Bhagwanjee31Departments of Medicine,...
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Từ khóa: báo cáo y họcbáo cáo y học cổ truyềnmẫu báo cáo y học cổ truyềnbao cao y hoc colchicinphan ban luan trong bao cao y hoc co truyenbáo cáo khoa học y họcbáo cáo y tế học đườngmẫu báo cáo y tế học đườngbáo cáo y tế học đường cuối nămbáo cáo y tế học đường năm 2012báo cáo y tế học đường trường mầm nonbiểu mẫu báo cáo y tế trường họcbáo cáo y tế học đường trường tiểu họcbáo cáo y tế trường tiểu họcbáo cáo y tế trường học năm 2012Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018chuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM