Báo cáo y học: "Capturing real-life patient care in psoriatic arthritis and its risks: the challenge of analysing registry data" docx

... thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability Yoshihiro Sambongi 1 , Susumu Uchiyama 2, *, Yuji Kobayashi 2 , Yasuo Igarashi 3 and Jun Hasegawa 4 1 Graduate ... and are applicable to the elucidation of the dynamic features of cytochromes c. It is of interest to characterize cytochrome...

Ngày tải lên: 24/03/2014, 03:21

... expected in the near future. The FinRaCo (Finnish RA Combination Therapy) [56] trial introduced the paradigm of ‘treating to target’: allowing therapeutic titration in those not achieving a prespecified ... over the past decade in trial design in RA. These include the following: ã Establishment of a clear regulatory path to demonstrate efficacy of a new therapeutic ã...

Ngày tải lên: 09/08/2014, 01:22

... inhibition of TNF-α and IL-1β production. This study examined the hypothesis that apoA-I may have a regulatory role at sites of macrophage activation by T lymphocytes in inflamed RA synovial tissue. Synovial ... pathogenesis and the maintenance of chronic inflammation in diseases such as RA. Regulating a potent mechanism that induces both IL- 1β and TNF-α may be important...

Ngày tải lên: 09/08/2014, 01:24

... 3 Research article Increased serum HO-1 in hemophagocytic syndrome and adult-onset Still's disease: use in the differential diagnosis of hyperferritinemia Yohei Kirino 1 , Mitsuhiro Takeno 1 , ... YK, MT, and MI, con- ducted the laboratory work. YK, MT, AU, SO, AS, HK, KT, and YI were involved in the analysis and interpretation of data. YK, MT,...

Ngày tải lên: 09/08/2014, 06:22

... immune sys- tem is further amplified by the results of the analysis of MHC II T cell epitopes using the ProPred server shown in Fig. 5b. Here we can see that the extremely disordered regions of the virus ... extremely disordered pro- teins. Thus X-ray studies of extremely disordered proteins tend either to focus on the ordered domains of the proteins that c...

Ngày tải lên: 09/08/2014, 07:20

... forward 5'-GCCTCTTCT- CATTCCTGCTT-3', reverse 5'-CACTTGGTGGTTT- GCTACGA-3'; for IL-1β, forward 5'- CCCAAGCAATACCCAAAGAA-3', reverse 5'-CATCAGAG- GCAAGGAGGAAA-3'; ... indicating that PPARγ agonists can inhibit activa- tion of monocyte/macrophages [34]. As macrophages initiate the inflammatory process and are the source of many cytokines responsib...

Ngày tải lên: 09/08/2014, 07:20

... synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes Ping Zhu 1 , Ning Lu 1 , Zhan-guo Shi 1 , Jun Zhou 2 , Zhen-biao Wu 1 , Yong ... zymography of culture medium conditioned by fibroblast-like synoviocytes (FLS) and monocytes/macrophagesGelatin zymography of culture medium conditioned by fibroblast-...

Ngày tải lên: 09/08/2014, 07:20

... primer). Results and discussion In marked contrast to previous findings, no polymorphic alleles (neither thymine at position 40 nor cytosine at position 1,400) were detected in any of the individuals tested. ... sur- prising because both positions were highly polymorphic in the original publications. In those publications, heterozygosity at position 40 (V14M) was detected in four in...

Ngày tải lên: 09/08/2014, 07:20

... assessment in RA. In this study, we showed that the assessment of joint activity in the feet, beyond assessment of joint activity by the 28-joint count, does not convey significant added value in the ... that while providing useful and important clinical information, the inclusion of ankles and feet only rarely influences the definition of overall disease activity status, e...

Ngày tải lên: 09/08/2014, 10:20

... neurotoxin. Review High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease David S Pisetsky 1, 2 , Helena Erlandsson-Harris 3 and Ulf Andersson 4 1 Division of Rheumatology ... mediated by HMGB1 and RAGE. Nat Immunol 2007, 8:487- 496. 59. Jiang W, Pisetsky DS: Expression of high mobility group protein 1 in...

Ngày tải lên: 09/08/2014, 10:23

... Changes in the methylation status of Review Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on? Aleksander ... of HAT activity to HDAC activity may sensitize cells to inflammatory gene transcription via chromatin remodeling, may increase the DNA binding and...

Ngày tải lên: 09/08/2014, 11:20

... perceivable in this study: the authors have adopted the methodology of looking at all treatment terminations and then at only those terminations for the reason of ineffectiveness and terminated for the ... withdrawal. In summary, the study by Saad and colleagues gives us important insights into daily-life use of TNF inhibitors in PsA, a disease that too often is se...

Ngày tải lên: 09/08/2014, 14:20

... biology and make the case for a more thorough and systematic investigation into its role in the immune system. â 2010 BioMed Central Ltd New role for Agrin in T cells and its potential importance ... only an assumption and it remains to be seen whether Agrin plays a role in the INF system. A working hypothesis on the function of Agrin in the...

Ngày tải lên: 12/08/2014, 12:20

... previously mentioned. The certificate course in critical care, the first organized training activity in critical care medicine, was started 4 years ago by the ISCCM and has been evolving well. ... who-is-who in critical care in India, but also many international stalwarts over the past 8 years. Good quality original work has now started emerging, and is being accepted for p...

Ngày tải lên: 12/08/2014, 19:21

... developing world Of the nearly 6 billion people in the world today, roughly 1 billion live in extreme poverty. They are nearly all inhabitants of ‘developing’ countries, predominantly in sub-Saharan ... without the accident of latitude. Tailored to the needs of the region, the provision of critical care has a role, even in the context of limited prevent...

Ngày tải lên: 13/08/2014, 11:22