Báo cáo y học: "Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis" docx
Báo cáo y học: "Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis" docx
... poten-
tial in vivo consequences of hypoxia in RA in terms of synovial
invasion, by exposing RA synovial membrane cells to 1% oxy-
gen. In our study, hypoxia upregulated MMP-2, MMP-8 and
MMP-9, ... expression by rheumatoid arthritis synovial cellsHypoxia modulates gelatinase expression by rheumatoid arthritis synovial cells. Rheumatoid arthritis synovial cells were e...
Báo cáo y học: "Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity" pot
... article
Four-year follow-up of infliximab therapy in rheumatoid arthritis
patients with long-standing refractory disease: attrition and
long-term evolution of disease activity
Bert Vander Cruyssen
1
, ... baseline and week 22, a further decrease in
disease activity was observed over the remaining 3.5 years.
This decrease in disease activity was observed in both the
patients wh...
Báo cáo y học: "Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues" doc
... FAK and Pyk2
associate with the cytoskeleton and with integrin-signaling
complexes by binding to Src kinase and paxillin [2-5]. FAK is
rapidly tyrosine phosphorylated on cell adhesion, creating ... that in OA ST.
Nevertheless, pFAK staining in RA ST lining and sublining was
significantly higher than in ND STs. We additionally showed
Figure 4
Immunostaining of pPaxillin is incr...
Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx
... immune
system. Type I IFNs stimulate monocyte maturation into DCs,
plasma cell maturation and immunoglobulin class switching,
cytotoxic T and natural killer cell activity, and chemokine
secretion. Type ... play pivotal roles in
SLE. TLR7 and TLR8 bind to single-stranded RNA, TLR3 to
double-stranded RNA, and TLR 9 to DNA. These receptors
are intracellular and are engaged by t...
Báo cáo y học: "Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept" pot
... and the intra-assay and inter-assay coefficient of
variation is <5%. The assay is not influenced by rheuma-
toid factors. The serum concentrations of COMP obtained
by this assay are highly ... levels
obtained by the original inhibition assay (r values >0.9 in
RA samples) (T Saxne and D Heinegård, unpublished).
Samples obtained at baseline and after 3 and 6 months of
therapy...
Báo cáo y học: "Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach" pdf
... WJ:
Expression and activity of citrullinating peptidylarginine deim-
inase enzymes in monocytes and macrophages. Ann Rheum
Dis 2004, 63:373-381.
16. Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt ... protein
mutations in Drosophila. J Cell Biol 1996, 133:1293-1305.
49. Hug C, Jay PY, Reddy I, McNally JG, Bridgman PC, Elson EL,
Cooper JA: Capping protein levels influence act...
Báo cáo y học: "Oral phosphatidylcholine pretreatment alleviates the signs of experimental rheumatoid arthritis" docx
... the lining layer and the cellular den-
sity of the synovial stroma), 0 to 3 points; leukocyte infiltration
of the joint, 0 to 3 points; inflammation-related cartilage dam-
age, 0 to 3 points; ... Visualiza-
tion and in situ analysis of leukocyte trafficking into the ankle
joint in a systemic murine model of rheumatoid arthritis.
Arthritis Rheum 2005, 52:3269-3278.
6. Moreland L: U...
Báo cáo y học: "Immunocytokines: the long awaited therapeutic magic bullet in rheumatoid arthritis" ppsx
... target fused to a
cytokine, thus retaining the functions of both the antibody and
the cytokine. In cancer, the use of single-chain antibody
fragments for targeting and in vivo imaging of tumors is ... neutralizing
anti-TNF-antibodies in the treatment of rheumatoid arthritis has
paved the way for using immunocytokines in non-lethal
diseases. The study of Kathrin Schwager and co...
Báo cáo Y học: Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells pot
... progestin primary target gene which
may have a potential role in progestin-induced growth
inhibition.
MATERIALS AND METHODS
Hormones
17b-Estradiol, MPA, dexamethasone, cycloheximide and
actinomycin ... angiotensin II type 1, interleukin 8 and C-C chem-
okine receptors. Chemokines [27,28] and angiotensin II [29]
have both shown growth-inhibiting properties with different
cancers. Int...
Báo cáo y học: "Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis" potx
... mtDNA-injected
mouse joints. It is also worth emphasizing that the process
of inflammation in RA joints is dynamic, with the infiltration
of new inflammatory cells, the death of resident cells, and
the continuous ... reactive oxygen intermediates and the presence of DNA
adducts exacerbate cellular damage in inflammatory loci,
thus creating a vicious circle of inflammation and cell...