Báo cáo y học: "Class-switched B cells display response to therapeutic B-cell depletion in rheumatoid arthritis" docx
Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt
... 2009 BioMed Central LtdBNIP = BCL2/adenovirus E 1B 19 kDa-interacting protein; C-TAD = carboxyl-terminal transactivating domain; FIH = factor inhibiting HIF; HIF =hypoxia-inducible factor; HRE ... ofinflammatory cytokines. The HIF transcription factor familymay thus represent an important convergence point in RA,integrating cellular responses to low oxygen tension and to inflammatory ... small interferingRNA against PHD-1 or PHD-2 or the pan-hydroxylaseinhibitor dimethyloxalylglycine (a 2-OG analogue, and aninhibitor of both PHD and FIH) resulted in NF- B activationvia serine...
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Báo cáo y học: "Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritis" pdf
... arthritisbeing initiated by complement-fixing autoantibodies thatbind to CII in the cartilage matrix [2]. In humans, IgG-pro-ducing B cells specific for CII are present in rheumatoid synovium and synovial ... an antibody level of 3 or more.CB10 and CB11 antibody detection by ELISAAntibodies against the purified CB peptides of bovine typeII collagen, namely CB10 and CB11, were measured byELISA ... antibody assay in rheumatoid arthritis. Int Orthop 1992, 16:272-276.16. Cook AD, Rowley MJ, Stockman A, Muirden KD, Mackay IR: Spe-cificity of antibodies to type II collagen in early rheumatoid arthritis....
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Báo cáo y học: "Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis" pptx
... major proinflammatory cytokines in RAjoints and stimulate IL-6 production by synovial fibroblasts [33-37], whereas IL-6 is a major circulating cytokine in RA thatinduces the acute phase response, ... remarkable efficacy of B- cell depletion in rheumatoid factor positive RA with rituximab [43] indicatesthat B cells are key contributors to the immunopathogenesisof RA. In a recent autopsy report ... conducted in the RA patients only (seebelow). Blood samples drawn for determination of cytokinesand biomarkers of endothelial dysfunction were stored at -70°C before laboratory testing. Cytokines...
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Báo cáo y học: "Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis" pptx
... anti-citrullinated peptideantibodies should therefore also be determined. The interac-tion between HLA-DRB1 genotypes and any new RA geneestablished by association and linkage, such as PTPN22Table ... PierlotC, Lasbleiz S, Bardin T, Prum B, Cornélis F: Rheumatoid arthritisseropositive for the rheumatoid factor is linked to the proteintyrosine phosphatase nonreceptor 22–620 W allele. ArthritisRes ... Epidemiol 1998,15:419-430.4. Rigby AS, MacGregor AJ, Thomson G: HLA haplotype sharing in rheumatoid arthritis sibships: risk estimates subdivided byproband genotype. Genet Epidemiol 1998, 15:403-418.5....
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Báo cáo y học: "Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis" pptx
... were obtained between October2005 and February 2006 from patients visiting the rheumaticoutpatient clinic (Clinical Department of Internal Medicine) ofthe Innsbruck Medical University (Innsbruck, ... RA is based on the cri-teria proposed by the American College of Rheumatology(ACR) in 1987 consisting of clinical symptoms and radiologi-cal findings, whereas the only laboratory test included ... an investi-gator-blinded fashion. Anti-CCP2 antibody reactivity wastested using a commercially available automated ELISA (EliA™CCP Assay;Phadia GmbH, Freiburg, Germany) on aImmunoCAP100 automatic...
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Báo cáo y học: " Characterisation of the immune response to type I collagen in scleroderma" pps
... 13-acetate)/ionomycin activated T cells. (a) We detected interferon (IFN)-γ staining but no interleukin (IL)-4 staining. Mul-tiplex cytokine assay was used to analyse the cytokine profile of three T-cell line ... by intracellular staining/flow cytometry and bymultiplex cytokine bead assay (Bio-Plex). A T-cell proliferative response to CI was detected in 8 of 25 (32%) SSc patients, butwas infrequent in ... assayed forcytokine content using a Bio-Plex assay. We detected abun-dant Th1 cytokines, including IL-2, IFN-γ, and TNF-α. Th2cytokines, including IL-4, IL-6, and IL-10, were present in muchlower...
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Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" pps
... GS, Gibson SB, El-Gabalawy HS: Regulation of apoptosis in fibroblast-like syn-oviocytes by the hypoxia-induced Bcl-2 family memberBcl-2/adenovirus E 1B 19-kd protein-interacting protein 3.Arthritis ... ofinflammatory cytokines. The HIF transcription factor familymay thus represent an important convergence point in RA,integrating cellular responses to low oxygen tension and to inflammatory ... invasionby synovium of underlying tissue such cartilage, bone andtendon. A variety of MMPs have been shown to be regulatedby hypoxia. When exposed to hypoxia, RA synovial fibroblastsexhibit increased...
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Báo cáo y học: "Infliximab concentration monitoring improves the control of disease activity in rheumatoid arthritis" doc
... purposes)infliximab in ankylosing spondylitis [18] and inflammatorybowel disease [19], but the determining factor in the concen-tration-effect relation of infliximab is infliximab itself.Only one ... ATI may have underestimated the infliximab determina-tion by neutralizing both infliximab paratopes. However, suchundetectable infliximab molecules are inactive and cannot betaken into account ... Company(Princeton, NJ, USA). PG participated in clinical trials as a co-investigator and as a study contributor for Abbott, Schering-Plough Corporation, Wyeth, Roche, and Bristol-Myers SquibbCompany and...
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Báo cáo y học: "TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies" pot
... Questionnaire in a trial comparinghydroxychloroquine vs. sulphasalazine. Scand J Rheumatol 1990,19:407-412.15. Shepherd J, Blauw GJ, Murphy MB, Cobbe SM, Bollen EL, Buckley BM, Ford I,Jukema JW, Hyland ... Study Group. PROspective Study of Pravastatin in the Elderly at Risk. Am J Cardiol 1999, 84:1192-1197.16. Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe SM, Ford I,Gaw A, Hyland ... Advances in the genetics of rheumatoid arthritis point to subclassification into distinct diseasesubsets. Arthritis Res Ther 2008, 10:205.8. Albers HM, Kurreeman FA, Houwing-Duistermaat JJ, Brinkman...
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báo cáo khoa học: "Bidirectional selection for olfactory response to acetaldehyde and ethanol in Drosophila melanogaster" docx
... appeared to respond mainly by walkingupwind. Hence this olfactometer probably measures mostly mechanical anemotacticreponses (see KENNEDY, 1977 a). Wind shear forces in the ... ethanollines, and this may obscure any role of the ADH locus in olfactory variation. Anincrease in the frequency of ADH-F has been reported in other laboratory selectionexperiments, ... correlated responses between odorants found in this study and by FUYAMA(1978) indicate genetic variation in olfactory response within populations specific to certain groups of...
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