Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis" doc

... Cloning: a Labora- tory Manual New York: Cold Spring Harbor Laboratory Press; 1989. 39. Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agar- wal P, Agarwala R, Ainscough R, Alexandersson ... significant upregulation of Tnfip6 suggests the activation of an anti- inflammatory cascade [51]. Thus, gene expression related to pro-inflammatory and anti-inflammatory events c...

Ngày tải lên: 09/08/2014, 06:22

... 3'-gttcgggaaccggattattta-3'; CDC2: 5'-ggtcaagtggtagccatgaaa-3' and 3'-ccaggagggata- gaatccaag-5'; and MKI67: 5'-ccccaaccaaaagaaagtctc-3' and 3'-gactaggagctggagggctta-5'. Histopathology ... 5'-gcccagctatgaactccttct-3' and 3'-tgaagaggtgagtggctgtct-5'; INDO: 5'-ggtcatggagatgtc- cgtaa-3' and 3'-accaatagagagaccagg...

Ngày tải lên: 09/08/2014, 14:20

... and accelerate endothelial damage repair [52,53]. Therefore the increase in VEGF gene expression after iloprost therapy may explain the EPCs increase in an attempt to repair the vascular damage. ... They correlate with physiological markers of endothelial damage/dysfunction and they have been identified as a marker of vascular damage in a variety of disorders, incl...

Ngày tải lên: 12/08/2014, 14:22

... TTC CCA AAT GAG TA 2 TTG ATT TGG AAA CCT CCA GC 3 CCA GGC TTC CCA AAT GAG TA GRO-β 2 GGC CAT TTT CTT GGA TTC CT 3 CCG AAG TCA TAG CCA CAC TC IL-6 2 GAA GAG CCC TCA GGC TGG ACT G 3 AGT AAC TCC ... Toivanen P: Expression of the myc-family proto-oncogenes and related genes max and mad in synovial tissue. Scand J Rheumatol 1999, 28:314-318. 37. Hashiramoto A, Sano H, Maekawa T, Kawahito...

Ngày tải lên: 09/08/2014, 01:22

... insights into disease pathogenesis and to aid with diagnosis and management are also discussed. Approach to the study of autoimmune disease A relatively small number of microarray studies in auto- immunity ... SLE and RA patients that were not included in the initial data analysis were subjected to scoring; none of these individuals had a score greater than 6, confirmi...

Ngày tải lên: 09/08/2014, 01:23

... 5'-GGGTTCCATGGTGAAGTCAAC 5'-6-FAM-TGTCCCGACCATTGCTGTTTCCTAGG-TAMRA IL-6 5'-CAAGACCATCCAACTCATCTTG 5'-CACAGTGAGGAATGTCCACAAAC 5'-6-FAM-TCGGCAAACCTAGTGTGCTATGCCTAAGCA-TAMRA TNF-α ... 5'-GGTTTCCTTGGAGACGGCTG 5'-6-FAM-ACAGGTCTACCAGCCCCTCAAGGACCG-TAMRA Ubiquitin 5'-CGAGAACGTGAAGGCCAAGA 5'-GGAGGACAAGGTGCAGGGTT 5'-6-FAM-CCCCTGACCAGCAGAGGCTCATCTTTG-TA...

Ngày tải lên: 09/08/2014, 06:22

... manner to release MMPs, proinflammatory cytokines and chemokines [13]. There is increasing evidence that SFs are key players in the pathogenesis of RA by invading and eroding hyaline cartilage. SFs, ... progressive systemic autoimmune disease that affects approximately 1% of the adult population. Proinflammatory cytokines and chemokines are considered to be the key regulators,...

Ngày tải lên: 09/08/2014, 14:20

... func- tion of each of these enzymes, although they are presumed to be active predominantly intracellularly [26,27]. Cathepsin H, cathepsin C, cathepsin F, cathepsin W, cathepsin B and cathepsin S are also ... Nara N, Kawakita Y, Takeshima Y, Arakawa M, Katoh M, Morita S, Iwatsuki K, Tanaka K, Okamoto S, Kitamura T, Seki N, Matsuda R, Matsuo M, Saito K, Hara T: Cloning of cDNA encod-...

Ngày tải lên: 09/08/2014, 14:22

... genes in the intrin- sicmitochondrialpathwayaswellastheTNFS F10 gene in the death receptor signaling pathway (Figure 2) [20]. Upregulation of the TNFSF10 gene activated the death rec eptor signaling ... BCL2L1, thereby inhibiting the anti-apoptotic func- tion and promoting Bax and Bak activation. This in turn activates the downstream caspases 3, 6, and 7, leading to incr...

Ngày tải lên: 10/08/2014, 21:23

... evident that all of them are prevalently induced from stage A to B and then mostly repressed. The main advantage of using MapMan is no doubt the ease and speed of the analysis. The visualization of the ... of applica- tion to the Affymetrix microarray platform. We have addi- tionally performed the first analysis of processes underlying the pathogenesis of E...

Ngày tải lên: 12/08/2014, 03:21