... func-tion of each of these enzymes, although they are presumed to be active predominantly intracellularly [26,27]. Cathepsin H,cathepsin C, cathepsin F, cathepsin W, cathepsin B andcathepsin S are also ... Nara N, Kawakita Y, Takeshima Y, Arakawa M, KatohM, Morita S, Iwatsuki K, Tanaka K, Okamoto S, Kitamura T, Seki N,Matsuda R, Matsuo M, Saito K, Hara T: Cloning of cDNA encod-ing a regeneration-associated ... shown to degrade other matrix proteins. Cathepsin K activity has beendemonstrated in human articular cartilage and has beenshown to play a role in collagen cleavage in at least a subset of OA patients...