Báo cáo y học: "Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate" pot
Báo cáo y học: "Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate" pot
... destruc- Figure 4 Association of synovial fluid analytes and osteoarthritis severityAssociation of synovial fluid analytes and osteoarthritis severity. Associ- ation of synovial fluid (a) isomerized aspartate ... showing a tendency to increased protein loss to the synovial fluid with increasing lesion severity and loss of GAG from the cartilage. The fact that...
Ngày tải lên: 09/08/2014, 14:20
Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"
... costly and has not been studied rigorously in a randomized controlled format to assess their value and impact on efficacy of therapy although they are now widely used in patients receiving interferon ... specifically G-CSF and erythropoietin, has allowed more aggressive dosing of interferon and ribavirin. [13, 14] Finally, growing experience with antiviral therapy in t...
Ngày tải lên: 31/10/2012, 17:11
Báo cáo y học: " Dual role of TRBP in HIV replication and RNA interference: viral diversion of a cellular pathway or evasion from antiviral immunity?" potx
... replication by inhibiting PKR and by increasing translation of structured RNAs. A recent report published in the Journal of Virology shows that the poor replication of HIV in astrocytes is mainly due ... Influenza virus NS1 and vaccinia E3L proteins, two inhibitors of the IFN-induced protein kinase R (PKR), inhibit RNAi pathways in plants and in Drosophila cells [12...
Ngày tải lên: 13/08/2014, 09:21
Báo cáo y học: " The effect of interleukin-13 (IL-13) and interferon-g (IFN-g) on expression of surfactant proteins in adult human alveolar type II cells in vitro" docx
... of the cultured cells (Figure 4A, B). The protein level of proSP-C in cell lysates from immunoblotting analysis measured by NIH Image was significantly decreased by IL-13 (relative increase of ... proSP-C by immunofluorescence of the cultured cells (Figure 4A, B). The protein level of proSP-C in cell lysate from immunoblotting analysed by NIH Image was also greatly inc...
Ngày tải lên: 12/08/2014, 11:23
Báo cáo y học: "Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins" pps
... representation of yeast proteins involved in protein-protein interactions found using yeast two-hybrid (Y2 H) assay, protein epitope-tag affinity purification/mass spectrometry (AP-MS) and protein microarray ... context of many WW domains and their protein ligands likely serves to increase the affinity of these interactions. Two broad classes of binding modes could increase...
Ngày tải lên: 14/08/2014, 16:21
Báo cáo y học: "The characterisation of mucin in a mature ovarian teratoma occurring in an eight year old patient
... The amino acid analysis of the purified mucin gave high amounts of ‘mucin-like amino acids, serine, threonine and proline. Serine and threonine are points of O-glycosylation found in the tandem ... mucin, widely expressed by normal glandular epithelial cells and dramatically increased in malignant cells of the breast, ovary and pancreas [15]. Mucin genes are indepen...
Ngày tải lên: 26/10/2012, 10:03
Báo cáo y học: " Mutation Analysis of hCDC4 in AML Cells Identifies a New Intronic Polymorphis"
... Biochemistry of the Charité, Berlin, Germany using the ABI PRISM Big Dye Terminator system (Applied Biosystems, Germany). Sequences were analyzed using the Chromas software (Technely- sium Pty Ltd, ... ubiquitin ligases which are involved in tagging proteins for degradation in the proteasome. hCDC4 has been shown to target specifically cyclin E [3], Myc [4], c-Jun [5] and Not...
Ngày tải lên: 31/10/2012, 16:49
Tài liệu Báo cáo Y học: Divergent members of a soybean (Glycine max L.) 4-coumarate:coenzyme A ligase gene family potx
... suitably ring-substituted cinnamoyl CoA esters as substrates (Fig. 6 ). However, phenyl ring modification involving hydroxylation and O-methylation can basically occur by different pathways, namely by ... substituted cinnamates including sinapate. This catalytic property is shared by only the minority of 4CL isoforms studied to date from any plant. As the cDNA encoding 4CL1 was a...
Ngày tải lên: 22/02/2014, 04:20
Báo cáo Y học: Functional reconstitution of the HIV receptors CCR5 and CD4 in liposomes pot
... Groningen, the Netherlands) in order to obtain a recombinant protein containing the C-myc epitope followed by six histidines at the C-terminus. A plasmid containing the wild type version of CCR5 ... concentration; insertion of detergent into the membrane should result in a gradual decrease of RET [41,42], and lysis of the liposomes in abrupt abolition of RET. A decrease i...
Ngày tải lên: 08/03/2014, 09:20
Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx
... recep- tors of the human and mouse PXR ligand binding domains. By modeling the human PXR ligand binding domain we have identified and mutated two polar residues in the puta- tive ligand binding pocket ... hepatomegaly and decreased bile acid excre- tion [16]. The aim of this study was to explore the molecular mechanism of ligand binding and activation of PXR by modeling...
Ngày tải lên: 08/03/2014, 16:20