Báo cáo y học: "Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is ne" pdf

... self-HSP60, while polyarticular patients did not [65]. This finding suggests a correlation between disease severity and HSP60 reactivity of T cells in these patients, in the sense that reactivity to ... protection from arthritis [64], as well as interference in ongoing arthritis [12]. The next obvious question is how this immune reactivity in experimental arthritis may relate to...

Ngày tải lên: 09/08/2014, 14:20

... manifestations. The association of CD4 + CD28 – T cells with disease status has given rise to the hypothesis that these cells directly contribute to disease manifestations. Patients with nodulosis and extra-articular ... in the absence of a costimulatory pathway. CD4 + CD28 – T cells contribute to the cell infiltrate and exhibit increased survival after apoptotic stimuli. Resis- t...

Ngày tải lên: 09/08/2014, 01:22

... of the wild-type protein and that loss of activity is associated either with perturbation of the native structure or local disruption of the metal binding or the active site. The point mutation ... exhibits an E a almost the same as in the case ofthenativeenzyme(Table1). Thermal inactivation of mutant and wild-type enzymes In order to investigate the effects of mutations on the stabil...

Ngày tải lên: 22/02/2014, 04:20

... started, LPO was higher than that obtained in the absence of urate (Fig. 1). In other words, urate is a pro- oxidant under these conditions. It is noteworthy that at the moment of urate addition, ... the urate catabolism pathway to elaborate other antioxidative mechanisms susceptible to cope with the loss of the capability to synthesize ascorbate. Compared with other mammals, the stro...

Ngày tải lên: 31/03/2014, 08:20

... encephalomyelitis in Lewis rats, the animal model for multiple sclerosis, reported that administration of the opioid antagonist naloxone markedly increases the severity of the condition [27]. In our study, ... [25]. Efficiency and toxicity are the two most important aspects in the search for potential pain gene therapies, with toxicity often being the limiting factor. Because the gene e...

Ngày tải lên: 09/08/2014, 01:23

... others observed that this cytokine protected T cells from apopto- sis [50,51]. We favor the hypothesis that TGF-β promotes the death of mature Th1 and Th2 cells while protecting newly generated regulatory T ... Central Ltd ( Print ISSN 1465-9905; Online ISSN 1465-9913) Abstract Regulatory T cells prevent autoimmunity by suppressing the reactivity of potentially aggressive self- r...

Ngày tải lên: 09/08/2014, 03:24

... and documentation of their in vivo potential was an important next step. In pursuit of this goal, recent studies demonstrated for the first time that the transfer of in vitro generated Treg into disease ... against self-recognition-induced autoimmunity is accomplished in large part by the central deletion of autoreactive T cells during intrathymic development, this process is...

Ngày tải lên: 09/08/2014, 06:22

... nonspecific symptoms. Discussion The main findings in the present study are that positive ANA status before the initiation of treatment with infliximab and use of infliximab without methotrexate in patients ... investigated. In summary, RA patients in whom ANA positive status is present at treatment initiation with infliximab and who are treated without methotrexate are at increased...

Ngày tải lên: 09/08/2014, 08:22

... Kvien TK: Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo County Rheumatoid Arthritis register. Arthritis Rheum ... Bone loss in unclassified pol- yarthritis and early rheumatoid arthritis is better detected by digital x ray radiogrammetry than dual x ray absorptiometry: relationship with disease...

Ngày tải lên: 09/08/2014, 10:20

... activity throughout the 10-year follow- up but not with joint damage. This discrepancy with previous reports may be due in part to the early start of therapy with disease-modifying anti-rheumatic ... not for citation purposes) Competing interests The authors declare that they have no competing interests. Authors' contributions NC participated in acquisition, analysis and interpretati...

Ngày tải lên: 09/08/2014, 13:21