Báo cáo y học: " Vasoactive intestinal peptide inhibits TNF-α-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands" docx

... TP53INP1 α and β expression in NOD acinar cells. Figure 2c shows TP53INP1 α and β mRNA and protein expression increased only in NOD mice acini com- pared with BALB/c acinar cells. A faint increase ... a pro-inflammatory triggering factor of exocrine dysfunction is currently explored in Sjogren's syndrome patients and in the nonobese diabetic (NOD) mouse model. Vasoac...

Ngày tải lên: 09/08/2014, 14:20

... vasoactive intestinal peptide (VIP) (d), pituitary adenylate cyclase-activating polypeptide 27 (PACAP27) (m) and dibutyryl-cAMP (db-cAMP) (j) in experiments on CSE (0.25%)-induced cytotoxicity in L2 cells. ... membranes and their inhibitory Fig. 1. RT-PCR analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) /vasoactive intestinal peptide (VIP) receptor mRNAs...

Ngày tải lên: 07/03/2014, 15:20

... either SF2/ASF prevents htopo I from binding to DNA or it impairs the reaction catalysed by the enzyme. The first mechanism has been revealed as underlying the inhibition of camptothecin-induced DNA cleavage ... SF2/ASF inhibits the reaction catalysed by htopo I (see below), stabilization of a rarely appearing cleavable complex by camptothecin could shift the equilibrium between htopo I en...

Ngày tải lên: 24/03/2014, 03:21

... glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest 1997, 99:457-468. 37. Le Maitre CL, Freemont AJ, Hoyland JA: The role of interleukin-1 in ... Hoyland JA, Freemont AJ: Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human interverte- bral disc: an...

Ngày tải lên: 09/08/2014, 10:23

... several genes encoding components of a complex that responds to DNA damage [17], including SMARCB1 (yeast YLR321C), MCM5 (yeast YLR274W), MCM6 (yeast YGL201C) and DBF4 (yeast YDR052C). In particular, ... The strains hemizygous for ATG11 (YPR049C), ATG14 (YLR295C) and ATG15 (YCR068W), whose gene products are involved in autophagy and vacuolar processing, display a haploinsufficient profile...

Ngày tải lên: 09/08/2014, 20:20

... bioassay The biolo gical activity of t he peptide lacking the glycosyl group was d emonstrated by injecting synthetic DUP99B (sDUP99B, s for synthetic; sDUP99B is not glycosylated) into the hemolymph ... of the asparagine-linked G lcNAc, which had been shown to inhibit de-glycosylation of g lycopeptides or glycoproteins by N-glycosidase F [27], N-glycosidase A was used for de-glycosylation....

Ngày tải lên: 08/03/2014, 22:20

... translo- cation and in poly(U)-directed polyphenylalanine synthesis [26,27], by preventing it from binding to the ribosome [28]. Early data showed that the phosphorylation of eEF2 was increased by very low ... of rapamycin, a protein which is discussed in more detail in the accompany- ing review by Proud [1]. Insulin has subsequently been shown to decrease eEF2 phosphorylation in pr...

Ngày tải lên: 23/03/2014, 21:20

... previously purified chondroitin lyases. Keywords: Bacteroides sterocirs HJ-15; chondroitin ABC lyase; chondroitin AC lyase; chondroitin sulfate; purifica- tion. Enzymes degrading glycosaminoglycans ... doi:10.1046/j.1432-1033.2002.02967.x 6-sulfate from shark cartilage), hyaluronic acid (rooster coomb), heparin (porcine intestinal mucosa), porcine heparan sulfate (porcine intestinal mucos...

Ngày tải lên: 31/03/2014, 23:20

... are similarly affected by CDDO. CDDO dose–response study in human primary chondrocytes To examine the effects of increasing doses of CDDO in human primary chondrocytes, cells were preincubated ... real-time reverse-transcriptase polymerase chain reaction. In SW-1353 cells, 300 nM CDDO significantly decreased the induction of MMP-1 and MMP-13 by IL-1. In human primary chondrocytes,...

Ngày tải lên: 09/08/2014, 01:23

... Although calcitonin gene-related peptide, neuropeptide Y, vasoactive intestinal polypeptide (VIP), BN/GRP and SP were all detectable in synovial fluid, only Commentary Gastrin-releasing peptide, substance ... two neuropeptides, bombesin/gastrin-releasing peptide (BN/GRP) and substance P (SP) with inflammatory cytokines. It is well known that proinflammatory cytokines have a fundam...

Ngày tải lên: 09/08/2014, 06:23