Báo cáo y học: "Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases" pps

... these findings underscore the complexity of the rheumatic diseases and highlight the key role of epidemiological research in understanding these intriguing conditions. Competing interests The authors ... 0.27%). Together, these findings indi- cate that there is constancy in the epidemiologic charac- teristics of ankylosing spondylitis. The incidence and prevalence...

Ngày tải lên: 09/08/2014, 14:20

... whether they currently smoked and the number of cigarettes smoked per day. From these reports, we calculated pack years of smoking (product of years of smoking and packs of cigarettes per day). Other ... cohort studies. The results of their study are slightly different from ours, in that they did not find a significant interaction between the presence of the PTPN2...

Ngày tải lên: 09/08/2014, 10:23

... in which male mice are treated with the alkylating agent ethinyl- nitrosourea, causing point mutations in sperm DNA. Offspring of these mice carry these mutations. By screening thousands of offspring ... using a variety of methods in twin and intergenerational studies, has been shown to be very high. Studies of female twins have shown heritability of BMD to be 57% to 92...

Ngày tải lên: 09/08/2014, 10:23

... testes of the X0 males, or males lacking the cry locus on the Y- chromosome. In this case the accumulated Stellate protein forms proteinaceous crystals in primary spermatocytes of the cry-defic ... a possibility of a replacement of one b subunit by another i n the case of a deficiency of any of the subunits, i.e. a so called ÔbypassÕ mechanism may operate in o...

Ngày tải lên: 21/02/2014, 15:20

... pitu- itary tumors, the first by expanding the patient base and the second, directly. In this context, using claims data, we examined whether there was potential bias in the report- ing of pituitary ... other typical antipsychotics grouped into a single category. Among the typicals, haloperidol and perphenazine were given indi- vidual attention because of their prominenc...

Ngày tải lên: 08/08/2014, 23:21

... & Therapy October 2005 Vol 7 No 5 Meyer and Pap at the same time they strengthen the concept of p38 and ERK as important MAPKs in the inflamed synovium. In line with previous data, the results ... MAPK kinases (MKKs), which largely determine the balance of MAPK activation in response to inflammatory stimuli [8,9]. The second interesting observation by Goertz and...

Ngày tải lên: 09/08/2014, 07:20

... linking inflammation to CHF and the lack of efficacy of anti-cytokine therapy in clinical trials in advanced CHF (discussed below). Because anti-cytokine therapy has become a cornerstone in the ... [112,115,116]. In the inflamed synovium of the rheumatoid joint, macrophage-derived cytokines such as TNF-α, IL-1 and IL-6 are prominently expressed, and inhibitors of...

Ngày tải lên: 09/08/2014, 07:20

... of the right and left hind paws in each mouse dur- ing day -4 and day 10. Horizontal bars represent the mean. DHMEQ, dehydroxymethylepoxyquinomicin. (b) Radiographic scores of the ankle joints ... The specimens from Figure 2 Effect of dehydroxymethylepoxyquinomicin on differentiation of osteoclasts in ankle joints of mice with collagen-induced arthritisEffect of...

Ngày tải lên: 09/08/2014, 10:21

... study provides further support of the influence of both tra- ditional and RA-specific risk factors in the development of CV events, especially myocardial infarction. As assessed by this study, the ... due to the cross-sectional nature of the study and some of the predictors being identified may be predictors of survival following a CV event rather than the occu...

Ngày tải lên: 09/08/2014, 10:23

... most prominent in the lining layer, in areas with cellular infiltrates and in certain blood vessel walls. Both an increased (Figures 1a,b) and decreased (Figures 1c,d) presence of HMGB1 protein in the ... sampling method and immunohistochemical analysis have previously been used to study the therapeutic effects of systemic infliximab therapy on the synovial expressio...

Ngày tải lên: 09/08/2014, 10:23